Nano lotus fiber/alginate porous material and preparation method thereof

Abstract

The invention discloses a nanometer lotus fiber / sodium alginate porous material and a preparation method thereof, belonging to the field of preparation of porous materials and processing and utilization of sodium alginate. The porous material is composed of 0.02% to 0.08% by weight of nanometer lotus fiber, 1% to 20% of oxidized sodium alginate, 0.6% to 10% of carboxymethyl chitosan, and the balance of solvent, wherein, The solvent is selected from one of deionized water, distilled water, physiological saline, water for injection or Ringer's solution. The present invention selects nanometer lotus fiber as the reinforcing body, oxidized sodium alginate as the base material, and carboxymethyl chitosan as the crosslinking agent. agent, and cross-link at a temperature of 20°C to 50°C to obtain a nanometer lotus fiber / sodium alginate porous material. The nanometer lotus fiber / sodium alginate porous material prepared by the present invention is a biodegradable biomaterial in a short period of time, has low cost, is convenient to use, is non-toxic to the human body, is antibacterial, and has good water absorption, biodegradability and biological properties. compatibility.

Description

technical field [0001] The invention relates to the field of preparation of medical porous materials and the processing and utilization of sodium alginate, in particular to a nanometer lotus fiber / alginate porous material with oxidized sodium alginate as a base material and a preparation method thereof. Background technique [0002] The choice of biomaterial determines the biocompatibility of the constructed porous scaffold material. Sodium alginate is a natural material extracted from seaweed plants, and is one of the natural biomaterials approved by the US Food and Drug Administration (FDA) for use in medical fields such as tissue engineering. Sodium alginate, a polysaccharide, has a similar structure to aminoglycans, a component of the skin dermal matrix, and has good biocompatibility. Skin fibroblasts, liver cells, chondrocytes, and osteoblasts are easily absorbed in alginate porous materials. In addition, sodium alginate also has good film-forming, gelling, hygroscopic...

AI Technical Summary

Problems solved by technology

Common chemical cross-linking agents in the prior art, such as hexamethylene glycol dihydrazide, polyethylene glycol-diamine and other dihydrazines or diamines, are toxic and difficult to completely remove, and are easy to damage human cells and tissues after use

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