Efficient antineoplastic lucid ganoderma extract and preparation method thereof

Abstract

The invention discloses an efficient antineoplastic lucid ganoderma extract. Supercritical CO2 extraction is implemented on one of the following raw materials: a lucid ganoderma fruiting body, a mixture of the lucid ganoderma fruiting body and edible grease, and a mixture of the lucid ganoderma fruiting body and a grease-enriched edible material; in the extracting process, natural grease in the raw material is taken out by the CO2 extraction under a supercritical state; the natural grease, as a natural entrainer and a carrier, can entrain and extract active materials, in particular triterpenoids, in the lucid ganoderma fruiting body, and the active materials are collected by a separation kettle. The extract disclosed by the invention is rich in ganoderma triterpene, as an efficient antineoplastic substance, in the lucid ganoderma fruiting body, and the preparation process is simple; through skilful specific setting of extracting method and active material carrier, extraction and enrichment process of the active material, namely preparation process of product, is completed in one step; in the lucid ganoderma extract, triterpenoids are rich and high in total content, and properties are stable; and the processing course is free from introduction of secondary pollutants and is safe to eat.

Description

technical field [0001] The invention relates to an anti-tumor extract, in particular to a high-efficiency anti-tumor ganoderma lucidum extract, which belongs to the technical field of medicine and health product preparation. Background technique [0002] Ganoderma lucidum, also known as Ruicao and Xiancao, is flat in nature and sweet in taste. It is a traditional Chinese medicine in my country. The Ganoderma lucidum mentioned in traditional Chinese medicine refers to the fruiting body of the red Ganoderma lucidum, so the fruiting body of the Ganoderma lucidum is the most authentic fungal medicinal part of the Ganoderma lucidum. The application of Ganoderma lucidum fruiting bodies in daily health care, diet therapy, and medicine has a long history in my country, and there are countless examples of use. For example, "Shen Nong's Materia Medica" in the Eastern Han Dynasty listed Ganoderma lucidum as a "prescription medicine" and believed that it has "benefiting the heart, calmi...

AI Technical Summary

Problems solved by technology

However, in practical applications, the yield is often too low, or the product cannot be collected at all. The reason is that the fat-soluble substances in the fruiting bodies of Ganoderma lucidum are too small, and all of them adhere to the equipment system pipes after being extracted from the extraction kettle. , it is difficult to collect the final product

Generally, the method of adding water, alcohol, ethyl acetate and other artificial entraining agents is used to entrain and extract the fruiting bodies of Ganoderma lucidum to overcome the above-mentioned deficiencies, but the extracted material contains inedible or even toxic entraining agents, and additional concentration or entrainment is required. The drying process is to reduce useless solvents and remove toxic solvents. This repeated processing method is likely to cause heat loss of Ganoderma lucidum triterpenoids and process loss caused by prolonging the process route, and the generally introduced entrainer has a high polarity, which changes the super Critical CO 2 Extract the original characteristics, losing the specificity of its extraction

Especially in the extraction of Ganoderma lucidum, entraining agents such as water, alcohol, glycerin, etc. are introduced to allow a large amount of highly polar impurities to enter the product, which affects the enrichment effect of the target functional substance Ganoderma lucidum triterpenoids, and thus destroys the specificity of extraction. After homogeneity, the product with uniform properties cannot be obtained, and product instability such as stratification, flocculation, emulsification, and precipitation will occur during long-term storage, and it is necessary to further perform complex follow-up separation and purification treatment on the supercritical extraction product

In addition, the introduction of polar entraining agents often easily leads to the enrichment and transfer of heavy metals in the raw materials to the product, so that the original technical advantages of supercritical extraction in eliminating heavy metal pollution in the product cannot be reflected, and the excessive heavy metals in the product will seriously affect human consumption. safety

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