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System and method for differentiation of normal myocardium from diffuse disease using T1 mapping in non-ischemic cardiomyopathies and others

A disease, myocardium technique used to differentiate normal myocardium from diffuse disease for improved patient care

Inactive Publication Date: 2015-01-28
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, a previous study used T1 mapping in patients with heart failure but showed no significant difference in native T1 values, highlighting the need for exemplary systems and methods as described herein

Method used

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  • System and method for differentiation of normal myocardium from diffuse disease using T1 mapping in non-ischemic cardiomyopathies and others
  • System and method for differentiation of normal myocardium from diffuse disease using T1 mapping in non-ischemic cardiomyopathies and others
  • System and method for differentiation of normal myocardium from diffuse disease using T1 mapping in non-ischemic cardiomyopathies and others

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Embodiment Construction

[0025] The present application is directed to systems and methods for distinguishing normal myocardium from diffuse disease in non-ischemic cardiomyopathy, among others, using Tl mapping. Specifically, the systems and methods utilize differences in T1 values ​​generated from the T1 map to differentiate between diseased and normal tissue. To achieve the above, the systems and methods utilize CMR T1 mapping using modified Look-Locker inversion recovery ( MOLLI) sequence. The exemplary method only requires a contrast agent in another embodiment. Rather, in another exemplary embodiment, virtually any other exact T1 mapping sequence may be used instead of MOLLI. Motion correction was performed on the acquired images prior to T1 map reconstruction. In the exemplary method, the MOLLI sequence generates 11 images that can be used for T1 map reconstruction. According to the exemplary methods described herein, Hierarchical Adaptive Local Affine Registration (HALAR) techniques may be...

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Abstract

A method for differentiation of normal myocardium from diffuse disease using T mapping includes acquiring one or more images of a patient by an imaging apparatus, generating a T1 map from the one or more images, defining a region of interest within the one or more images, determining the average T1 value within the region of interest, comparing the average T1 value within the region of interest to a cut-off T1 value, and determining a diagnosis of the region of interest from the comparison.

Description

technical field [0001] This application relates to the fields of medicine, magnetic resonance and related fields. The present application finds particular application in systems and methods related to the use of Tl mapping to differentiate normal myocardium from diffuse disease in non-ischemic cardiomyopathy and others. It is to be understood, however, that it applies to other applications as well, and is not necessarily limited to the aforementioned applications. Background technique [0002] This application is related to U.S. Application 61 / 613626 (filed March 21, 2012), which discloses exemplary embodiments of systems and methods according to the present application, and has been performed in connection with patients with hypertrophic and dilated cardiomyopathy are described as exemplary applications of such exemplary systems and methods. This application is also related to US application 61 / 753083 (filed January 16, 2013). The disclosures of both US applications 61 / 6...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/055A61B5/7292A61B5/0044A61B5/7207A61B5/7246A61B5/7282A61B5/748G01R33/5601G01R33/5602
Inventor T·R·福格特A·J·维特霍夫T·R·舍夫特E·C·C·纳格尔V·O·蓬特曼
Owner KONINKLJIJKE PHILIPS NV
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