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Mycophenolate mofetil dispersible tablet

A technology of mycophenolate mofetil and dispersible tablets, applied in the field of medicine, can solve the problems of easy moisture absorption of preparations, increase the cost of preparations, difficult to pass through No. 2 sieve, etc., and achieve the effects of small tablet weight, rapid disintegration and rapid dissolution

Active Publication Date: 2015-03-04
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of a large number of disintegrants increases the cost of the preparation, and also makes the preparation easy to absorb moisture, which has high requirements for the production environment and packaging materials, and the subsequent stability of the preparation cannot be well guaranteed; Large particles, difficult to pass through No. 2 sieve, does not meet the definition of dispersible tablets in Pharmacopoeia

Method used

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  • Mycophenolate mofetil dispersible tablet
  • Mycophenolate mofetil dispersible tablet
  • Mycophenolate mofetil dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] Preparation Process:

[0022] Pass mycophenolate mofetil, calcium sulfate, and sodium carboxymethyl starch through a 100-mesh sieve, weigh the prescription amount, mix well, add 1% povidone aqueous solution to granulate, dry at 60°C, pass the dry granules through a 20-mesh sieve, and then Mix evenly with glyceryl monostearate, and press into tablets.

Embodiment 2

[0024]

[0025] Preparation Process:

[0026] Mycophenolate mofetil, calcium sulfate, and croscarmellose sodium were passed through a 120-mesh sieve, and the prescription amount was weighed, mixed evenly, added with 1% hydroxypropyl methylcellulose aqueous solution to granulate, dried at 55°C, and dried The granules are passed through a 18-mesh sieve, then mixed evenly with glyceryl monostearate, and pressed into tablets.

Embodiment 3

[0028]

[0029] Preparation Process:

[0030] Mycophenolate mofetil, calcium sulfate, and low-substituted hydroxypropyl cellulose are passed through a 120-mesh sieve, and the prescription amount is weighed, mixed evenly, granulated by adding 1% hydroxypropyl methylcellulose aqueous solution, dried at 55°C, and dry granules Pass through a 18-mesh sieve, then mix evenly with glyceryl monostearate, and press into tablets.

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Abstract

The invention discloses a mycophenolate mofetil dispersible tablet. The tablet consists of mycophenolate mofetil, calcium sulfate, glycerin monostearate, a disintegrating agent and an adhesive. Compared with the prior art, the mycophenolate mofetil dispersible tablet prepared by the invention is small in tablet weight and rapid in dissolution and disintegration and does not need lots of disintegrating agents, the disintegrated granules can smoothly pass through a No.2 sieve, and the mycophenolate mofetil dispersible tablet is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a mycophenolate mofetil dispersible tablet and a preparation method thereof. Background technique [0002] About 70,000 people around the world receive organ transplants every year, most of which are kidney transplants. In China, more than 5,000 patients receive kidney transplants every year. How to improve the long-term survival rate of transplanted organs has always been a major problem in the medical field. The human immune system has the ability to recognize "self" and "non-self". Usually, it only produces an immune response to foreign antigens, but immune tolerance to self-antigens. Therefore, the immune system's rejection of allografted organs hinders the success of organ transplantation. Although the immunosuppressive regimen composed of macrolide antibiotic structure immunosuppressants, calcineurinase inhibitors, and adrenal cortex hormones has been relativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5377A61K47/04A61K47/14A61P37/06
Inventor 张贵民郝贵周郭增光
Owner SHANDONG NEWTIME PHARMA
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