Immunological adjuvant containing fucosan sulfate and application of immunological adjuvant

A technology of fucoidan sulfate and immune adjuvant, which is applied in the field of biotechnology and biomedicine, can solve the problems of few types of immune adjuvants and cannot meet infectious diseases, and achieve the reduction of insufficient production, the reduction of antigen dosage, and the enhancement of Immunogenic effects

Inactive Publication Date: 2015-03-04
WEIHAI RENSHENG PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the technical problem that there are few types of immune adjuvants, unavoidable side effects, and the need to provide a large number of vaccines when infectious diseases break out, and provides a vaccine containing Immune Adjuvant of Fucoidan Sulfate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of Nanoemulsion Vehicle (A):

[0021] (1) Weigh 1.5g of Tween 80, 1.0g of Span80, and 1.5g of polyethylene glycol with a molecular weight of 400 Daltons, add them to a glass container, stir at room temperature for 3 to 10 minutes, and rotate at 300 rpm. After mixing, add 4g of soybean oil for injection, continue stirring and mixing to obtain a mixture;

[0022] (2) Add 4 g of water for injection dropwise to the mixture in the above step (1), stir at room temperature at 260 rpm for 5 to 15 minutes to obtain a nanoemulsion carrier.

Embodiment 2

[0024] Preparation of nanoemulsion carrier (B):

[0025] (1) Weigh 0.04g Tween 80, 0.04g Span80, and 0.12g polyethylene glycol with a molecular weight of 400 Daltons respectively, add them to a glass container, stir at room temperature for 3-10 minutes, and rotate at 300 rpm, After mixing, add 4g of soybean oil for injection, continue stirring and mixing to obtain a mixture;

[0026] (2) Add 4 g of water for injection dropwise to the mixture in the above step (1), stir at room temperature at 260 rpm for 5 to 15 minutes to obtain a nanoemulsion carrier.

Embodiment 3

[0028] Preparation of nanoemulsion carrier (C):

[0029] (1) Weigh 0.4g Tween 80, 0.8g Span80, and 1.2g polyethylene glycol with a molecular weight of 400 Daltons respectively, add them to a glass container, stir at room temperature for 3-10 minutes, and rotate at 300 rpm, After mixing, add 0.05g soybean oil for injection, continue stirring and mixing to obtain a mixture;

[0030] (2) Add 4.0 g of water for injection dropwise to the mixture in the above step (1), stir at room temperature at 260 rpm for 5-15 minutes to obtain a nanoemulsion carrier.

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PUM

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Abstract

The invention relates to an immunological adjuvant containing fucosan sulfate and application of the immunological adjuvant. The technical problems that at present, the kinds of immunological adjuvants are few, side effects cannot be avoided, and a great number of vaccines need to be provided when infectious diseases break out are solved. The immunological adjuvant consists of the following components in mass ratio: fucosan sulfate, ginsenoside and the rest of carriers, wherein the carriers consist of the following components in mass ratio: an emulsifying agent, an emulsifying auxiliary agent, oil phase and aqueous phase. The immunological adjuvant can be widely used in the preparation field of vaccines.

Description

technical field [0001] The invention relates to an immune adjuvant containing fucoidan sulfate, and also relates to an influenza vaccine containing the fucoidan sulfate immune adjuvant, which belongs to the fields of biotechnology and biomedicine. Background technique [0002] Fucoidan sulfate, as an intercellular polysaccharide inherent in brown algae such as kelp, exists in the cell wall matrix of brown algae and is a unique biologically active substance of brown algae. For example, Fucoidan extracted from kelp (Laminaria japonicia) is mainly composed of sulfate-containing fucose; secondly, it is also accompanied by a small amount of galactose, mannose, wood Sugar, arabinose, uronic acid, etc. are water-soluble heteropolysaccharides, also known as fucoidan and fucoidan sulfate. The main active ingredient is α-L-fucose-4-sulfate . [0003] Fucoidan sulfate is an excellent raw material for health food and pharmaceuticals. Because it naturally contains sulfate groups, it ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P31/16
Inventor 苗笑晨苗其壮
Owner WEIHAI RENSHENG PHARMA GRP
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