A kind of pharmaceutical composition for treating insomnia and preparation method thereof

The technology of a composition and medicine is applied in the field of pharmaceutical composition for treating insomnia and its preparation, and achieves the effects of shortening sleep induction period, low production cost and wide source of raw materials

Active Publication Date: 2016-08-24
秘传(北京)科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no literature report that horseshoe leaf extract has sedative and hypnotic effects

Method used

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  • A kind of pharmaceutical composition for treating insomnia and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of water chestnut leaf ether extract

[0017] Accurately weigh 0.5kg of dry water chestnut leaf medicinal material, chop it, put it into a 6L round bottom flask, add petroleum ether at a ratio of 1:8 (kg:L), soak for 30min, and place it in a constant temperature water bath at 75°C Reflux extraction for 3 times, the first reflux extraction for 1 hour, the second reflux extraction for 45 minutes, the third reflux extraction for 30 minutes, filter, and discard the filtrate after recovering petroleum ether. After the filter residue was volatilized to remove petroleum ether, put it into a 6L round bottom flask In the method, diethyl ether was added at a ratio of solid to liquid of 1:8 (kg:L), soaked for 30 minutes, and placed in a constant temperature water bath at 40°C for reflux extraction for 3 times, the first reflux extraction was for 1 hour, the second reflux extraction was for 45 minutes, and the third Reflux for 30 minutes, filter, and c...

Embodiment 2

[0018] Embodiment 2: the preparation of water chestnut leaf ether extract

[0019] Accurately weigh 1.0kg of dry water chestnut leaf medicinal material, chop it, put it into a 10L round bottom flask, add petroleum ether at a material-liquid ratio of 1:7 (kg:L), soak for 45min, and place it in a constant temperature water bath at 75°C Reflux extraction 3 times, the first reflux extraction for 1.5h, the second reflux extraction for 1h, the third reflux extraction for 30min, filter, and discard the filtrate after recovering petroleum ether. In the bottom flask, add diethyl ether according to the ratio of solid to liquid of 1:7 (kg:L), soak for 45 minutes, put it in a constant temperature water bath at 40°C for reflux extraction for 3 times, the first reflux extraction for 1.5h, and the second reflux extraction for 1h , the 3rd reflux extraction for 30min, filtered, combined 3 extracts, the filtrate recovered the solvent under reduced pressure on a rotary evaporator, and the conce...

Embodiment 3

[0024] Experimental research on the sedative and hypnotic effect of the horseshoe leaf extract of embodiment 3 on mice

[0025] 50 clean-grade Kunming mice, half male and half male, weighing (20±2) g. They were randomly divided into blank control group, positive control group, ether extract group, ethanol extract group and ethyl acetate extract group, with 10 animals in each group, half male and half male. The ether extract group was given 40.0 mg / kg of the water chestnut ether extract prepared in Example 1 of the present invention, the ethanol extract group was given 40.0 mg / kg of the horseshoe leaf ethanol extract prepared in the above comparative example 1, and the ethyl acetate extract group Give the horseshoe leaf ethyl acetate extract 40.0mg / kg that above-mentioned comparative example 2 prepares, and positive control group gives diazepam 2mg / kg, and blank control group gives equal-volume normal saline; Once a day, for 3 consecutive days, the volume of gavage is 15ml / kg....

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Abstract

The invention discloses a medicine composition for treating insomnia and a preparation method for the medicine composition. The medicine composition is prepared from a ligularia fischeri extract and pharmaceutically available auxiliary materials, wherein the ligularia fischeri extract is ether extract of ligularia fischeri. The preparation method comprises the following steps: performing reflux extraction on ligularia fischeri by using petroleum ether, filtering, discarding the filtrate, and performing reflux extraction on the obtained filter residue by using ether to obtain the medicine composition. By adopting the medicine composition, not only is the fall-asleep time shortened, that is, the sleep induction period is shortened, but also the sleep time is prolonged, and the sleep depth is increased.

Description

technical field [0001] The invention belongs to the technical field of extraction of plant active ingredients, and in particular relates to a pharmaceutical composition for treating insomnia and a preparation method thereof. Background technique [0002] Insomnia is one of the most common clinical symptoms. It is a disorder in the initiation and maintenance of sleep. The quality of sleep cannot meet the physiological needs of the human body, thereby affecting normal activities during the day, and a sleep disorder with symptoms such as fatigue, decreased concentration, and unresponsiveness. syndrome. The pace of modern life is getting faster and faster, and many people have huge pressure from various aspects, which makes it impossible to guarantee normal sleep, and some people cannot fall asleep because of the huge pressure. Frequent insomnia leads to inattention, decreased comprehension ability, reduced learning efficiency, and memory loss, which will affect people's workin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P25/20
CPCA23V2002/00A61K36/71A61K2236/35A61K2236/39A61K2236/51A23V2200/30A23V2200/31A23V2250/21
Inventor 张寿涛马慧林绪涛孙慧莉尚义美
Owner 秘传(北京)科技有限公司
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