Multi-channel label-free biosensing fiber optic system

Abstract

The invention provides a multichannel unmarked biosensing optical fiber system which comprises a light source, an optical fiber loop, an optical switch, multiple optical fibers and an optical detection part, wherein the light source is coupled into the optical fibers; the optical fiber loop is used for coupling or / and directionally transmitting light waves transmitted by the optical fibers; the optical switch is used for inputting and outputting the optical fibers; reflective unmarked optical sensing elements are arranged at the ends of the optical fibers; the optical switch for inputting and outputting the optical fibers comprises multi-path output and / or multi-path input; and the reflected light of the reflective unmarked optical sensing elements at the specified optical fiber ends in the multi-path output and / or multi-path input is received by the optical detection part by virtue of the switch, and thus multichannel sensing is realized. The multichannel parallel unmarked biosensing optical fiber system provided by the invention can be used for detecting multiple biological samples. Because the optical fiber loop, the optical switch and other means in the optical fiber communication technology are fused, the system can comprise an optical detection part only, the systematic complexity is greatly reduced, the size of the system is reduced, and the system is high in stability.

Description

technical field [0001] The invention belongs to the field of biological sensing and instrument design, in particular to a multi-channel label-free biological sensing optical fiber system. Background technique [0002] Quantitative measurement of biomolecular interactions is widely used in basic life science research, new drug screening and development, and food industry. Traditional detection and analysis use enzyme-linked immunosorbent adsorption technology, but label-free optical biosensing technology that does not require fluorescent labels has developed rapidly in recent years. The advantage of label-free sensing technology is to maintain the natural characteristics of the sample, and greatly save the time and labor of operators; more importantly, the label-free sensing technology can measure the dynamic process of molecular interaction in real time, which is very important in scientific research. It has important value in drug screening. [0003] In the label-free opt...

AI Technical Summary

Problems solved by technology

However, the reported label-free biosensing optical fiber systems lack good compatibility with optical fiber communication technology. When realizing multi-channel sensing, they either use difficult-to-operate transmission detection frameworks, or still partially rely on free-space optical transmission.

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