Medicament composition with anti-anoxia action and preparation method of medicament composition
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A composition and anti-hypoxia technology, which is applied in the field of medicine, can solve undiscovered problems, achieve the effect of definite activity and improve hypoxia tolerance
Active Publication Date: 2015-04-01
YANTAI HUAXIN BIOPHARM TECH CO LTD
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Problems solved by technology
[0007] Before the completion of the present invention, no composition composed of total saponins of Tribulus terrestris extracted from Tribulus terrestris, Centella asiat
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Embodiment 1
[0048] Embodiment 1, Preparation of Total Saponins from Tribulus Terrestris
[0049] Tribulus terrestris 5kg, reflux extraction with 70% ethanol for 3 times, each time for 2 hours, filter, recover ethanol from the filtrate to obtain ethanol extract, add water to contain 1.0g medicinal material per 1ml, pass through the pre-treated D-101 macroporous resin column , first eluted with deionized water for 5 times the column volume, discarded the eluent, then eluted with 70% ethanol for 4 times the column volume, collected the eluate, recovered the ethanol, dried, and obtained the total saponins of Tribulus terrestris.
Embodiment 2
[0050] Embodiment 2, Preparation of Centella Asiatica Extract
[0051] 5 kg of Centella asiatica was extracted twice with 12 times the amount of deionized water, each time for 2 hours, filtered, the filtrate was concentrated, and dried to obtain Centella asiatica extract.
Embodiment 3
[0052] Embodiment 3, Preparation of total flavonoids from Grape dentata
[0053] 5kg of Grape dentatus, reflux extraction with 70% ethanol for 2 times, each time for 3 hours, filter, recover ethanol from the filtrate to obtain ethanol extract, add water until each 1ml contains 1.0g medicinal material, pass through the pre-treated AB-8 macropore Resin column, first eluted with deionized water for 4 times the column volume, discarded the eluent, then eluted with 15% ethanol for 3 times the column volume, discarded the eluent, and then eluted with 80% ethanol for 5 times the column volume , collect the eluent, recover the ethanol, and dry to obtain the total flavonoids of the Serpentis dentata grape.
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Abstract
The invention discloses a medicament composition with the anti-anoxia action. The medicament composition is characterized by being prepared from the components including an extractive of herba centellae with anti-inflammatory and anti-exudation performance as well as total saponins of tribulus and ampelopsis grossedentata total flavonoids with anti-ischemic and anti-anoxia functions for the first time. According to the composition of the formula, except considering the basis of ischemia and hypoxia resistant substances, the medicament composition is characterized by considering emergency prevention and treatment of inflammatory exudation and edema of cardio-cerebrovascular tissues caused by ischemia and anoxia. Proved by pharmacodynamic experiments, compared with medicine containing only one of extractive of the herba centellae, total saponins of tribulus and ampelopsis grossedentata total flavonoids, the medicament composition is stronger in activity, is capable of reflecting the synergistic effect among chemical components of traditional Chinese medicines, can be prepared into oral preparations including hard capsules, tablets, granules, powder, pills, tea bags and oral liquids and can be used in Chinese patent medicines or health foods which are beneficial to improving the anoxia endurance.
Description
technical field [0001] The invention relates to a natural medicine composition with anti-hypoxia effect and a preparation method, belonging to the technical field of medicine. Background technique [0002] Oxygen is an important condition for the survival of human beings and many organisms. When the oxygen required by the body's vital activities cannot be supplied adequately, it is called hypoxia or hypoxia. Hypoxia will cause abnormal changes in body metabolism, function, and even morphological structure. Severe or long-term hypoxia will bring serious harm to the body, and eventually lead to the death of important organs such as the heart and brain due to insufficient energy supply. Oxygen and hypoxia are important topics in the basic theory of life sciences. The formation of hypoxia can be divided into three categories: the first category is the reduction of oxygen content in the external environment, which makes it impossible to take in enough oxygen during normal phys...
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