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Preparation method of compound recipe andrographitis thin membrane coated tablet

A compound andrographis paniculata, film coating technology, applied to non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of coating layer thickness, lobes, and complexity, and achieve good results. Bleeding, good adhesion, good hydrophilic effect

Inactive Publication Date: 2015-04-22
广西世彪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets
However, many pharmaceutical companies still have many problems in the application due to the complexity of drug coating raw materials and technical reasons for preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of preparation method of compound Andrographis paniculata film-coated tablet:

[0026] 1) Raw material processing: Take 600g of Andrographis paniculata and 1400g of Lubianqing, grind them into fine powder respectively, take 540g of Andrographis paniculata fine powder and 1400g of Lubianqing fine powder, mix them, add 3 times the amount of water and ultrasonically extract for 30min, centrifuge, add 2 times of medicinal residues Measure water and ultrasonically extract for 30 minutes, centrifuge, combine the decoction, let it stand, filter, and concentrate the filtrate into a thick paste with a relative density of 1.26 (70°C);

[0027] 2) Tablet compression: add the remaining Andrographis paniculata fine powder, mix well, add auxiliary materials, make granules, and compress into 1000 plain tablets;

[0028] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the p...

Embodiment 2

[0035] A kind of preparation method of compound Andrographis paniculata film-coated tablet:

[0036] 1) Raw material processing: Take 600g of Andrographis paniculata and 1400g of Lubianqing, grind them into fine powder respectively, take 540g of Andrographis paniculata fine powder and 1400g of Lubianqing fine powder, mix them, add 3 times the amount of water and ultrasonically extract for 30min, centrifuge, add 2 times of medicinal residues Measure water and ultrasonically extract for 30 minutes, centrifuge, combine the decoction, let it stand, filter, and concentrate the filtrate into a thick paste with a relative density of 1.32 (70°C);

[0037] 2) Tablet compression: add the remaining Andrographis paniculata fine powder, mix well, add auxiliary materials, make granules, and compress into 1000 plain tablets;

[0038] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pot...

Embodiment 3

[0045] A kind of preparation method of compound Andrographis paniculata film-coated tablet:

[0046] 1) Raw material processing: Take 600g of Andrographis paniculata and 1400g of Lubianqing, grind them into fine powder respectively, take 540g of Andrographis paniculata fine powder and 1400g of Lubianqing fine powder, mix them, add 3 times the amount of water and ultrasonically extract for 30min, centrifuge, add 2 times of medicinal residues Measure water and ultrasonically extract for 30 minutes, centrifuge, combine the decoction, let it stand, filter, and concentrate the filtrate into a thick paste with a relative density of 1.30 (70°C);

[0047] 2) Tablet compression: add the remaining Andrographis paniculata fine powder, mix well, add auxiliary materials, make granules, and compress into 1000 plain tablets;

[0048] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the p...

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Abstract

The invention discloses a preparation method of a compound recipe andrographitis thin membrane coated tablet. The preparation method of the compound recipe andrographitis thin membrane coated tablet comprises the following steps: 1) processing raw materials, namely weighing 600 parts by weight of andrographitis and 1400 parts by weight of clorodendron eyrtophyllum, grinding the andrographitis and clorodendron eyrtophyllum into fine powder, weighing 540 parts by weight of andrographitis fine powder and 1400 parts by weight of clorodendron eyrtophyllum fine powder, mixing, adding water with the weight 3 times that of the mixture, carrying out ultrasonic extraction for 30 minutes, centrifuging, adding water with the weight 2 times that of herb residue, carrying out ultrasonic extraction for 30 minutes, centrifuging, mixing decoctions, standing, filtering, and concentrating filtrate to obtain thick paste; 2) tabletting, namely adding the rest of andrographitis fine powder, uniformly mixing, adding auxiliary materials, granulating, and pressing to obtain compressed tablets; 3) coating, namely putting the compressed tablets into a coating pan, and spraying all the coating fluid by adopting a rolling coating method, wherein dosage of the coating fluid is 0.02-0.05 part by weight, and the coating fluid is composed of the following components in percentage by weight: 10-15% of sodium hydroxyethyl cellulose, 10-15% of momordica grosvenori swingle extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and balance of purified water.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of compound Andrographis paniculata film-coated tablets. Background technique [0002] Pharmaceutical coating is to spray a thin film with good stability on the tablet embryos pressed from raw materials to cover up the taste of the drug tablet itself and increase the stability of the tablet, avoiding chemically active drugs and other substances Deterioration due to chemical reaction, etc. The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients accessories. Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K36/19A61K9/36A61K47/46
CPCA61K36/19A61K9/288A61K36/73A61K2236/331A61K2236/39
Inventor 张辉
Owner 广西世彪药业有限公司
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