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33results about How to "Strong mechanical shear" patented technology

Preparation method for phycocyanin polypeptide

The invention relates to a preparation method for a phycocyanin polypeptide, which includes the following steps: phycocyanin is added with water for being stirred to be sufficiently dissolved, so that a phycocyanin solution is obtained; the phycocyanin solution is added with papain or neutral protease, uniform stirring is carried out and then ultrasonical treatment is carried out for 30 to 50 minutes, so that an enzymolysis product is obtained; the enzymolysis product is heated to 85 DEG C to 95 DEG C which is kept for 5 to 15 minutes, and after enzyme deactivation, cooling and centrifugation, supernatant, i.e. enzymolysis liquid, is extracted; ultrafiltration treatment is carried out on the enzymolysis liquid, so that an ultrafiltrate is obtained; the ultrafiltrate is concentrated under vacuum, and after spray-drying treatment, the phycocyanin polypeptide is obtained. The preparation method for the phycocyanin polypeptide adopts ultrasound-assisted enzymolysis, ultrasonic waves have a cavitation effect, produced air bubbles are squeezed to break to instantly produce extremely strong mechanical shear force, so that protein is degraded or protein conformation is changed, consequently, more hydrophilic groups are promoted to expose, the solubility of phycocyanin in water is increased, the binding between enzyme and phycocyanin substrate is benefited, and the efficiency of enzymolysis of phycocyanin can be remarkably increased.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI

Preparation method of compound danshen root thin film coated tablets

The invention discloses a preparation method of compound danshen root thin film coated tablets. The preparation method comprises the following steps: (1) performing raw material treatment, namely taking 450 parts by weight of danshen root, 141 parts by weight of panax notoginseng and 8 parts by weight of borneol, adding 95% ethanol into danshen root, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; adding 50% ethanol into medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; and adding water into the medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, and concentrating a filtrate to form a thick paste; (2) tabletting, namely crushing panax notoginseng into fine powder, mixing with the thick pastes and auxiliary materials to prepare granules, drying, finely grinding borneol, uniformly mixing with the granules, and pressing to obtain compressed tablets; and (3) coating, namely putting the compressed tablets into a coating pan, and treating the compressed tablets by adopting a trundle pan coating process until coating liquid is completely sprayed, wherein the use amount of the coating liquid is 0.02-0.05 parts by weight, and the coating liquid consists of the following components in percentage by weight: 10-15% of sodium hydroxyethyl cellulose, 10-15% of a grosvener siraitia extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and the balance of purified water.
Owner:广西世彪药业有限公司

Preparation method of bezoar detoxifying film coated tablet

The invention discloses a preparation method of a bezoar detoxifying film coated tablet. The method comprises the following steps: 1) raw material treatment, namely, taking the following raw materials in parts by weight: 5 parts of calculus bovis factitious, 50 parts of realgar, 200 parts of gypsum, 200 parts of rhubarb, 50 parts of scutellaria baicalensis, 100 parts of platycodon grandiflorum, 25 parts of borneol and 50 parts of liquorice, crushing realgar into superfine powder, crushing rhubarb into fine powder, grinding the calculus bovis factitious and borneol, decocting water and decocting the other materials twice and two hours each time, merging decoction, filtering and concentrating the filtrate into thick paste; (2) tabletting, namely, adding rhubarb and realgar powder, and 8 parts of auxiliary starch to be prepared into particles, drying, adding the calculus bovis factitious powder and the borneol powder, mixing evenly and tabletting to prepare the tablet; and (3) coating, namely, putting the tablet into a coating pan, directly spraying a coating solution by trundle pan coating, wherein the amount of the coating solution is 0.02-0.05 part by weight, the coating solution comprises the following components in percentage by weight: 10%-15% of carboxyethyl cellulose, 10%-15% of a momordica grosvenori extract, 1%-3% of microcrystalline cellulose, 0.1%-0.5% of guar gum and the balance of purified water.
Owner:广西世彪药业有限公司

Preparation method of compound recipe andrographitis thin membrane coated tablet

The invention discloses a preparation method of a compound recipe andrographitis thin membrane coated tablet. The preparation method of the compound recipe andrographitis thin membrane coated tablet comprises the following steps: 1) processing raw materials, namely weighing 600 parts by weight of andrographitis and 1400 parts by weight of clorodendron eyrtophyllum, grinding the andrographitis and clorodendron eyrtophyllum into fine powder, weighing 540 parts by weight of andrographitis fine powder and 1400 parts by weight of clorodendron eyrtophyllum fine powder, mixing, adding water with the weight 3 times that of the mixture, carrying out ultrasonic extraction for 30 minutes, centrifuging, adding water with the weight 2 times that of herb residue, carrying out ultrasonic extraction for 30 minutes, centrifuging, mixing decoctions, standing, filtering, and concentrating filtrate to obtain thick paste; 2) tabletting, namely adding the rest of andrographitis fine powder, uniformly mixing, adding auxiliary materials, granulating, and pressing to obtain compressed tablets; 3) coating, namely putting the compressed tablets into a coating pan, and spraying all the coating fluid by adopting a rolling coating method, wherein dosage of the coating fluid is 0.02-0.05 part by weight, and the coating fluid is composed of the following components in percentage by weight: 10-15% of sodium hydroxyethyl cellulose, 10-15% of momordica grosvenori swingle extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and balance of purified water.
Owner:广西世彪药业有限公司

A kind of preparation method of Niuhuangjiedu film-coated tablet

The invention discloses a preparation method of a bezoar detoxifying film coated tablet. The method comprises the following steps: 1) raw material treatment, namely, taking the following raw materials in parts by weight: 5 parts of calculus bovis factitious, 50 parts of realgar, 200 parts of gypsum, 200 parts of rhubarb, 50 parts of scutellaria baicalensis, 100 parts of platycodon grandiflorum, 25 parts of borneol and 50 parts of liquorice, crushing realgar into superfine powder, crushing rhubarb into fine powder, grinding the calculus bovis factitious and borneol, decocting water and decocting the other materials twice and two hours each time, merging decoction, filtering and concentrating the filtrate into thick paste; (2) tabletting, namely, adding rhubarb and realgar powder, and 8 parts of auxiliary starch to be prepared into particles, drying, adding the calculus bovis factitious powder and the borneol powder, mixing evenly and tabletting to prepare the tablet; and (3) coating, namely, putting the tablet into a coating pan, directly spraying a coating solution by trundle pan coating, wherein the amount of the coating solution is 0.02-0.05 part by weight, the coating solution comprises the following components in percentage by weight: 10%-15% of carboxyethyl cellulose, 10%-15% of a momordica grosvenori extract, 1%-3% of microcrystalline cellulose, 0.1%-0.5% of guar gum and the balance of purified water.
Owner:广西世彪药业有限公司

A kind of preparation method of compound salvia miltiorrhiza film-coated tablet

The invention discloses a preparation method of compound danshen root thin film coated tablets. The preparation method comprises the following steps: (1) performing raw material treatment, namely taking 450 parts by weight of danshen root, 141 parts by weight of panax notoginseng and 8 parts by weight of borneol, adding 95% ethanol into danshen root, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; adding 50% ethanol into medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, recycling ethanol from a filtrate, and concentrating to form a thick paste; and adding water into the medicine residues, performing ultrasonic wave extraction for 30 minutes, centrifuging, and concentrating a filtrate to form a thick paste; (2) tabletting, namely crushing panax notoginseng into fine powder, mixing with the thick pastes and auxiliary materials to prepare granules, drying, finely grinding borneol, uniformly mixing with the granules, and pressing to obtain compressed tablets; and (3) coating, namely putting the compressed tablets into a coating pan, and treating the compressed tablets by adopting a trundle pan coating process until coating liquid is completely sprayed, wherein the use amount of the coating liquid is 0.02-0.05 parts by weight, and the coating liquid consists of the following components in percentage by weight: 10-15% of sodium hydroxyethyl cellulose, 10-15% of a grosvener siraitia extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and the balance of purified water.
Owner:广西世彪药业有限公司

A kind of preparation method of compound Houttuynia cordata film-coated tablet

The invention discloses a method for preparing compound houttuynia cordata thin membrane coated tablets. The method comprises the following steps: (1) performing raw material treatment, namely taking the following five medicines in parts by weight: 583 parts of houttuynia cordata, 150 parts of radix scutellariae, 150 parts of radix isatidis, 58 parts of fructus forsythiae and 58 parts of honeysuckle flower, grinding 200 parts of houttuynia cordata, fructus forsythiae and honeysuckle flower into fine powder, grinding and mixing the residual houttuynia cordata, radix scutellariae and radix isatidis, adding water in an amount being three times of the amount of the mixture, ultrasonically extracting for 30 minutes, centrifuging, adding water in an amount being two times of the amount of decoction dregs into the decoction dregs, ultrasonically extracting for 30 minutes, centrifuging, merging the decoction, filtering, and concentrating the filtrate into thick paste; (2) tabletting, namely preparing the fine powder, thick paste and auxiliary materials into granules, drying, and tabletting into compressed-tablets; and (3) coating, namely adding the compressed-tablets into a coating pan, and performing trundle pan coating until the coating solution is sprayed completely, wherein the amount of the coating solution is 0.02-0.05 weight part, and the coating solution comprises the following components in percentage by weight: 10-15 percent of carboxymethylcellulose sodium, 10-15 percent of Momordica grosvenori extract, 1-3 percent of microcrystalline cellulose, 0.1-0.5 percent of guar gum and the balance of purified water.
Owner:广西世彪药业有限公司
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