The invention discloses a preparation method of a bezoar detoxifying film coated tablet. The method comprises the following steps: 1) raw material treatment, namely, taking the following raw materials in parts by weight: 5 parts of calculus bovis factitious, 50 parts of realgar, 200 parts of gypsum, 200 parts of rhubarb, 50 parts of scutellaria baicalensis, 100 parts of platycodon grandiflorum, 25 parts of borneol and 50 parts of liquorice, crushing realgar into superfine powder, crushing rhubarb into fine powder, grinding the calculus bovis factitious and borneol, decocting water and decocting the other materials twice and two hours each time, merging decoction, filtering and concentrating the filtrate into thick paste; (2) tabletting, namely, adding rhubarb and realgar powder, and 8 parts of auxiliary starch to be prepared into particles, drying, adding the calculus bovis factitious powder and the borneol powder, mixing evenly and tabletting to prepare the tablet; and (3) coating, namely, putting the tablet into a coating pan, directly spraying a coating solution by trundle pan coating, wherein the amount of the coating solution is 0.02-0.05 part by weight, the coating solution comprises the following components in percentage by weight: 10%-15% of carboxyethyl cellulose, 10%-15% of a momordica grosvenori extract, 1%-3% of microcrystalline cellulose, 0.1%-0.5% of guar gum and the balance of purified water.