Preparation method of isatis root film coated tablets

A technology of film coating and Radix Radix is ​​applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of coating thickness, lobes, and high labor intensity, and achieve good results. Bleeding, good adhesion, good hydrophilic effect

Active Publication Date: 2015-05-27
广西世彪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of isatidis film-coated tablet:

[0027] 1) Raw material processing: take 1000g Radix Radix Radix, add water and ultrasonically extract twice, each time for 30min, filter, combine the filtrate, concentrate the filtrate to 1000g, place it at room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.15 (50°C);

[0028] 2) Tablet compression: add 200g of starch and auxiliary materials to make granules, and press into 1000 plain tablets;

[0029] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the pot at 35-37°C, and use the continuous spraying method to spray depending on the dryness of one side Film coating solution until the coating solution is sprayed;

[0030] The dosage of the coating solution is 0.02%, and the coating solution i...

Embodiment 2

[0036] A preparation method of isatidis film-coated tablet:

[0037] 1) Raw material processing: take 1000g Radix Radix Radix, add water and ultrasonically extract twice, each time for 30min, filter, combine the filtrate, concentrate the filtrate to 1000g, place it at room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.20 (50°C);

[0038] 2) Tablet compression: add 200g of starch and auxiliary materials to make granules, and press into 1000 plain tablets;

[0039] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the pot at 35-37°C, and use the continuous spraying method to spray depending on the dryness of one side Film coating solution until the coating solution is sprayed;

[0040] The dosage of the coating solution is 0.05%, and the coating solution i...

Embodiment 3

[0046] A preparation method of isatidis film-coated tablet:

[0047] 1) Raw material processing: take 1000g Radix Radix Radix, add water and ultrasonically extract twice, each time for 30min, filter, combine the filtrate, concentrate the filtrate to 1000g, place it at room temperature, add 95% ethanol to make the alcohol content reach 60%, refrigerate, filter, The filtrate is concentrated into a thick paste with a relative density of 1.18 (50°C);

[0048] 2) Tablet compression: add 200g of starch and auxiliary materials to make granules, and press into 1000 plain tablets;

[0049] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating liquid with a sprayer, keep the temperature in the pot at 35-37°C, and spray with intermittent spraying method depending on the dryness of one side Film coating solution until the coating solution is sprayed;

[0050] The dosage of the coating solution is 0.03%, and the coating solution is comp...

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PUM

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Abstract

The invention discloses a preparation method of isatis root film coated tablets. The preparation method comprises the following steps of: (1) raw material treatment: adding 1000 parts by weight of isatis roots, extracting for two times by ultrasonic wave and 30min for each time, filtering, combining filtrates, concentrating the filtrate to 1000 parts by weight, cooling to room temperature, adding 95% ethanol to enable the ethanol content to reach 60%, refrigerating, filtering, and concentrating the filtrate to be thick paste; (2) tabletting: adding 200 parts by weight of starch and accessories, forming particles, and compressing to be tablets; and (3) coating: placing the tablets into a coating boiler, and spraying a coating liquid by the rolling coating method, wherein the dosage of the coating liquid is 0.02-0.05 parts by weight, and the coating liquid comprises the following components in percentage by weight: 10-15% of sodium carboxyethyl cellulose, 10-15% of momordica grosvenori extract, 1-3% of microcrystalline cellulose, 0.1-0.5% of guar gum and the balance of pure water.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of isatidis film-coated tablets. Background technique [0002] Film coating agent is a kind of material for coating oral tablets, usually composed of film forming agent, plasticizer, auxiliary additive and coloring agent, when used, water or a mixture of water and ethanol is used as a solvent, sprayed on The surface of the drug core can form a smooth and uniform film coat, so that the drug core can avoid the erosion of light, oxygen, and moisture, and can beautify the appearance, improve the taste, and cover the odor. [0003] Film coating technology is a production process of wrapping tablets with a small amount of safe, non-toxic and stable physical and chemical polymer materials. The safety of these polymer coating materials has long been widely recognized by countries all over the world. Therefore, the development trend of coating t...

Claims

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Application Information

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IPC IPC(8): A61K36/195A61K36/315A61K9/36A61K47/46
Inventor 苏朝芳
Owner 广西世彪药业有限公司
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