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A kind of preparation method of Niuhuangjiedu film-coated tablet

A film coating, bezoar detoxification technology, applied in the directions of medical preparations containing active ingredients, antidote, pharmaceutical formulations, etc., can solve the problems of splinter, thick coating layer, high labor intensity, etc. Sticky, uniform surface effect

Active Publication Date: 2017-05-17
广西世彪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients Accessories
Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more than 70%), and it is prone to mottling, discoloration, lobes, etc., and it cannot be packaged. Enteric-coated tablets

Method used

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  • A kind of preparation method of Niuhuangjiedu film-coated tablet
  • A kind of preparation method of Niuhuangjiedu film-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of preparation method of Niuhuangjiedu film-coated tablet:

[0025] 1) Raw material processing: Take 5g of artificial bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 50g of skullcap, 100g of bellflower, 25g of borneol, 50g of licorice, fly realgar into fine powder, crush rhubarb into fine powder, grind artificial bezoar and borneol fine; the other four flavors of Scutellaria baicalensis and other four flavors are decocted twice with water, 2 hours each time, the decoctions are combined, filtered, and the filtrate is concentrated into a thick paste with a relative density of 1.20 (70°C);

[0026] 2) Tablet compression: add rhubarb, realgar powder, and 8 g of auxiliary material starch to make granules, dry, then add artificial bezoar and borneol powder, mix well, and compress into 1,500 plain tablets (small pieces);

[0027] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, ke...

Embodiment 2

[0034] A kind of preparation method of Niuhuangjiedu film-coated tablet:

[0035] 1) Raw material processing: Take 5g of artificial bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 50g of skullcap, 100g of bellflower, 25g of borneol, 50g of licorice, fly realgar into fine powder, crush rhubarb into fine powder, grind artificial bezoar and borneol fine; the other four flavors of Scutellaria baicalensis and others are decocted twice with water, 2 hours each time, combined with the decoction, filtered, and the filtrate is concentrated into a thick paste with a relative density of 1.25 (70°C);

[0036] 2) Tablet compression: add rhubarb, realgar powder, and 8 g of auxiliary material starch to make granules, dry, then add artificial bezoar and borneol powder, mix well, and compress into 1,500 plain tablets (small pieces);

[0037] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating liquid with a sprayer, keep the tempera...

Embodiment 3

[0044] A kind of preparation method of Niuhuangjiedu film-coated tablet:

[0045] 1) Raw material processing: Take 5g of artificial bezoar, 50g of realgar, 200g of gypsum, 200g of rhubarb, 50g of skullcap, 100g of bellflower, 25g of borneol, 50g of licorice, fly realgar into fine powder, crush rhubarb into fine powder, grind artificial bezoar and borneol fine; add water and decoct the other four flavors such as Scutellaria baicalensis twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate into a thick paste with a relative density of 1.22 (70°C);

[0046] 2) Tablet compression: add rhubarb, realgar powder, and 8 g of auxiliary material starch to make granules, dry, then add artificial bezoar and borneol powder, mix well, and compress into 1,500 plain tablets (small pieces);

[0047] 3) Coating: Put the plain tablets into the coating pot, use the rolling coating method, spray the coating solution with a sprayer, keep the temperature in the pot a...

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PUM

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Abstract

The invention discloses a preparation method of a bezoar detoxifying film coated tablet. The method comprises the following steps: 1) raw material treatment, namely, taking the following raw materials in parts by weight: 5 parts of calculus bovis factitious, 50 parts of realgar, 200 parts of gypsum, 200 parts of rhubarb, 50 parts of scutellaria baicalensis, 100 parts of platycodon grandiflorum, 25 parts of borneol and 50 parts of liquorice, crushing realgar into superfine powder, crushing rhubarb into fine powder, grinding the calculus bovis factitious and borneol, decocting water and decocting the other materials twice and two hours each time, merging decoction, filtering and concentrating the filtrate into thick paste; (2) tabletting, namely, adding rhubarb and realgar powder, and 8 parts of auxiliary starch to be prepared into particles, drying, adding the calculus bovis factitious powder and the borneol powder, mixing evenly and tabletting to prepare the tablet; and (3) coating, namely, putting the tablet into a coating pan, directly spraying a coating solution by trundle pan coating, wherein the amount of the coating solution is 0.02-0.05 part by weight, the coating solution comprises the following components in percentage by weight: 10%-15% of carboxyethyl cellulose, 10%-15% of a momordica grosvenori extract, 1%-3% of microcrystalline cellulose, 0.1%-0.5% of guar gum and the balance of purified water.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Niuhuangjiedu film-coated tablets. Background technique [0002] Pharmaceutical coating is to spray a thin film with good stability on the tablet embryos pressed from raw materials to cover up the taste of the drug tablet itself and increase the stability of the tablet, avoiding chemically active drugs and other substances Deterioration due to chemical reaction, etc. The traditional coating technology is sugar coating, and the excipients used are mainly talcum powder, syrup, etc. The sugar-coated tablets using talc powder can increase the weight of the drug tablet core by 50-100%, causing patients to take a large amount irrelevant to the drug ingredients accessories. Traditional sugar coating has the following disadvantages: high labor intensity, cumbersome process, thick coating layer, many materials (tablet weight gain is more tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K9/30A61P39/02A61K35/413A61K33/06A61K33/36
CPCA61K9/288A61K31/045A61K33/06A61K33/36A61K35/413A61K36/346A61K36/484A61K36/539A61K36/708A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 罗肖城
Owner 广西世彪药业有限公司
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