A method for constructing parametric model of white matter fibers based on healthy population

Abstract

The invention discloses a method for establishing white matter fiber parameterized model based on a health crowd. The method comprises the steps that firstly, definitive type whole-brain fiber bundle tracking is conduced on a tensor atlas, and interested fiber bundles are extracted; according to the average nearest distance rule, the fiber bundles are bound into a bundle, for the bound fiber bundle, archetype fibers are selected with a local density weighting method, discretization is conducted on the archetype fibers according to the arc length so that a public coordinate system can be established; corresponding relations between points on other fibers of the fiber bundle and points on the archetype fibers of the fiber bundle are established with an optimal point matching algorithm. Finally, individual fiber feature is mapped into an atlas fiber bundle through cubic linear interpolations, a feature curve of individual examinees is obtained, and therefore the parameterized model of health crowd is established.

Description

technical field [0001] The invention belongs to the technical field of diffusion tensor imaging, and relates to a method for constructing a white matter fiber parametric model based on healthy people. Background technique [0002] Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that can detect the diffusion movement of water molecules in the living body. It is non-invasive and has been widely used in brain science research. Brain white matter fiber tract imaging based on diffusion tensor imaging technology is one of the hotspots in neuroscience research at present. It uses the diffusion tensor direction information to track the diffusion state of water molecules in the brain, and can obtain the shape and topology of white matter fiber tracts. structure and spatial location. The fiber tracking display can be used for planning before neurosurgery, positioning guidance during surgery, and postoperative treatment and evaluation. white matter disease of...

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Problems solved by technology

[0005] However, the TBSS method can only analyze the white matter fiber bundles on the skeleton, and cannot obtain the damage of white matter in other places.

Probabilistic fiber tracking can only describe the existence and general direction of fiber bundles between two brain regions, but cannot quantify the local shape of fiber bundles, resulting in the inability to make group comparisons between healthy people and patients

Therefore, the current mainstream research methods have limitations and cannot meet the needs of clinical research and diagnosis

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