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Application of jasmine leaf extract

A technology of gardenia leaves and extracts, applied in the field of biomedicine, can solve problems such as no medicinal reports, and achieve the effects of reducing production costs and risks, having broad uses, and improving equipment utilization and capital turnover cycle.

Inactive Publication Date: 2015-04-29
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Gardenia tree is a common ornamental and greening shrub in my country. Its flowers are beautiful and fragrant, and its fruit is a traditional medicinal material in my country. Geniposide is an internationally recognized main active ingredient in the traditional Chinese medicine Gardenia jasminoides, but its leaves have no medicinal reports. The previous research of the present invention found that gardenia leaves contain a large number of biologically active components, and its composition and activity are similar to those of gardenia fruit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The concrete preparation operation steps of gardenia leaf extract are as follows:

[0017] 1. Harvesting gardenia leaves

[0018] Collection of gardenias without pests and diseases and pollution ( Gardenia jasminoides Ellis) leaves, which can be harvested in combination with pruning. The collected fresh leaves are directly used for extraction;

[0019] Gardenia leaf pulp preparation

[0020] 100 kg of fresh gardenia leaves and water were mixed and beaten according to the material-to-liquid ratio of 1:0.2 (w / v), stirred and extracted at 10°C and 20 rpm for 200 minutes to obtain 110L gardenia leaf slurry;

[0021] 3. Preparation of Gardenia Leaf Extract

[0022] Centrifuge the gardenia leaf pulp at 3,000 rpm for 20 minutes, add 70 kg of centrifuged sediment to a material-to-liquid ratio of 1:0.2 (w / v), add water, stir and wash once, and centrifuge at 3,000 rpm for 5 minutes, and combine all centrifuged The supernatant was finely filtered through an 80-mesh siev...

Embodiment 2

[0029] The concrete preparation operation steps of gardenia leaf extract are as follows:

[0030] (1) Harvesting of gardenia leaves

[0031] Collecting no pests and diseases, pollution-free water gardenia ( Gardenia jasminoides var. radicans Makino ) leaves, which can be harvested in combination with shaping and pruning. The collected fresh leaves are directly used for extraction;

[0032] (2) Preparation of leaf pulp

[0033] 100 kg of fresh gardenia leaves and 80% methanol were mixed and beaten according to the material-to-liquid ratio of 1:2 (w / v), stirred and extracted at 95°C and 100 rpm for 20 minutes to obtain 260 L of gardenia leaf pulp;

[0034] (3) Preparation of gardenia leaf extract

[0035] Filter the gardenia leaf pulp with a 20-mesh screen to obtain 80 kg of filter residue, add 80% methanol to the filter residue at a material-to-liquid ratio of 1:2 (w / w), stir and wash twice, and filter with a 20-mesh screen, and combine all Filtrate, finely filtered throu...

Embodiment 3

[0042] The concrete preparation operation steps of gardenia leaf extract are as follows:

[0043] 1. Harvesting gardenia leaves

[0044] Collecting no pests and diseases, pollution-free small-leaf Gardenia ( Gardenia angkorensis ) leaves, which can be harvested in combination with shaping and pruning. The collected leaves are dried and used for extraction. The drying conditions are: -50°C, 0.001 atmosphere pressure (vacuum freezing) drying;

[0045] Gardenia leaf pulp preparation

[0046] Mix and beat 100 kg of dried gardenia leaves and water according to the material-to-liquid ratio of 1:1 (w / v), stir and extract at 20°C and 60 rpm for 30 minutes to obtain 180L of gardenia leaf slurry;

[0047] 3. Preparation of Gardenia Leaf Extract

[0048] Filter 180L gardenia leaf pulp with a 60-mesh sieve, and add 140 kg of filter residue obtained by filtering according to the ratio of material to liquid 1:0.2 (w / v), add water, stir and wash once, centrifuge at 6000 rpm for 20 m...

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Abstract

The invention relates to application of a jasmine leaf extract. The content of gardenoside in the jasmine leaf extract is 8-15 percent. The invention also relates to application of the jasmine leaf extract in preparation of medicines with functions of clearing away heat and toxic materials, moistening dryness and decreasing internal head, and protecting the liver and benefiting the bile. The invention further relates to application of the jasmine leaf extract in preparation of anticancer medicines. Because jasmine leaves and jasmine fruits have similar pharmacological activities and main active components, the jasmine leaves can replace the jasmine fruits to be used in production of relevant medicines. Because the yield of the jasmine leaves is above 25 times of that of the jasmine fruits, when the jasmine leaves are used for producing the relevant medicines, the production cost can be greatly lowered; on the other aspect, because the jasmine leaves are rich in sources, and can be supplied in full year, the extract can be produced in full year, so that the rate of equipment utilization and the cash conversion cycle are greatly improved, and the production cost and risk are reduced.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the use of plant active ingredients. Background technique [0002] Gardenia tree is a common ornamental and greening shrub in my country. Its flowers are beautiful and fragrant, and its fruit is a traditional medicinal material in my country. Geniposide is an internationally recognized main active ingredient in the traditional Chinese medicine Gardenia jasminoides, but its leaves have no medicinal reports. The preliminary research of the present invention found that gardenia leaves contain a large number of biologically active components, and its composition and activity are similar to those of gardenia fruit. Contents of the invention [0003] The invention provides the application of active ingredients of gardenia leaf extract. [0004] The content of gardenoside (gardenoside) in the gardenia leaf extract is 8-20%, and the application of the gardenia leaf extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K31/7048A61P1/16A61P39/06A61P35/00A61P29/00A61K127/00
Inventor 胡丰林胡旋陆瑞利
Owner ANHUI AGRICULTURAL UNIVERSITY
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