The invention discloses a
traditional Chinese medicine composition for treating
sepsis as well as a preparation method and application of the
traditional Chinese medicine composition. The
traditional Chinese medicine composition is prepared from 1-15 parts of
sulfur, 3-25 parts of calamitas urinae hominis, 1-20 parts of
wine-treated rhubarb, 10-30 parts of fructus
cannabis, 10-50 parts of
radix bupleuri, 5-30 parts of
scutellaria baicalensis, 5-25 parts of folium isatidis, 5-25 parts of peach kernels, 5-30 parts of
salvia miltiorrhiza, 5-30 parts of
angelica sinensis, 5-30 parts of
sophora flower
charcoal, 5-25 parts of fructus gardeniae praeparatus and 5-60 parts of
wine-treated fructus corni. According to the invention, through a combined mode of'monarch
drug targeted
oral administration and synergistic decoction of minister, assistant and guide drugs', the whole-course intervention of'upstream inhibition,
midstream blocking and downstream regulation 'on
sepsis immune disorder can be realized, meanwhile, the functions of warming yang, dispelling cold, cooling blood and detoxifying are taken into account, and the pro-inflammatory / anti-inflammatory balance is successfully recovered to a physiological state; the action mode is superior to that of a traditional single anti-inflammatory strategy and a traditional Chinese
medicine application mode of whole-prescription decoction. In a standard
animal model, the traditional Chinese
medicine composition definitely shows the
dose-dependent extremely remarkable effects of anti-
inflammation, immunoregulation, multi-
organ protection and overall condition improvement, the
curative effect of a high-
dose group of the traditional Chinese
medicine composition is equivalent to that of a classic potent medicine, and the traditional Chinese medicine composition has more advantages in the aspects of recovering immune
homeostasis, warming yang and strengthening the
body resistance.