Injection biogel containing tripterigium wilfordii dlycosides

Abstract

The invention discloses injection biogel containing tripterigium wilfordii dlycosides. The injection gel comprises tripterigium wilfordii dlycosides and biogel substrates for injection. If the biogel is used for cell culturing, a cell culturing liquid can also be added into the gel substrates. The problem that immunological rejection is resistant after the administration of Chinese medicinal tripterigium wilfordii dlycosides so as to inconveniently medicate, and particularly, the rejection resistant treatment on local transplants is not ideal are solved; by injecting the tripterigium wilfordii dlycosides biogel through a local subcutaneous injection or muscle injection manner, the medicines are slowly and locally released, and the immunological rejection effect of anti-local transplants is achieved. Through the design of the injection biogel containing the tripterigium wilfordii dlycosides, a research on immunosuppressive agents of the medicine at home and abroad can be promoted, and the biogel has a certain application value. The injection biogel is simple in principle, convenient to use and can reach scale massive production; and moreover, the injection biogel lays a foundation for development and clinical test of new medicines of the preparation.

Description

technical field [0001] The invention relates to a biological glue for injection containing tripterygium glycosides, in particular to a drug delivery system for injection against acute immune rejection of the body after organ transplantation, which is used for the anti-transplantation immunity after organ transplantation of animals or humans. Treatment of rejection. Background technique [0002] Immune rejection is a process in which the body destroys a graft (alternative cell, tissue or organ) through a specific immune response. It generally means that after transplantation, the recipient can recognize the graft antigen and respond, and the immune cells in the graft can also recognize the recipient antigen tissue and respond. In allogeneic transplantation, there are two basic types of rejection: host versus graft reaction (HVGR) and graft versus host reaction (GVHR), the former is the most common in clinic; , speed and clinical manifestations, HVGR can be divided into 3 ty...

AI Technical Summary

Problems solved by technology

[0020] In view of the current situation that the traditional Chinese medicine anti-immune rejection drugs have a single dosage form and few varieties, and there are fewer anti-immune rejection drugs that can be made into injectable slow-release gels, with the improvement of tripterygium glycosides and injection gels The research on release drug delivery system continues to deepen. We have designed this new type of injectable rapamycin gel, which can improve the drug compliance of experimental animals and make up for the deficiency of conventional oral immunosuppressants. The study of immune rejection pharmaceutical preparations has certain application value