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Propolis pellets and preparation method thereof

A technology of propolis pellets and propolis is applied in the field of medicine and food to achieve the effects of rapid onset and high bioavailability

Inactive Publication Date: 2015-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, propolis products are well received by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above dosage forms is long; A certain part of the body disintegrates, which is irritating to the gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take the following ingredients for the recipe

[0031] propolis 10g Crystalline Cellulose 82g Hydroxypropylmethylcellulose 4g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take the amount of propolis in the above formula, add microcrystalline cellulose, pulverize it to a micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] propolis 15g starch 85g Polyvinylpyrrolidone 5g

[0039] Prepare pellet formulations as follows:

[0040] (1) Take the amount of propolis in the above formula, add starch, grind to micronized level with a ball mill, and mix well;

[0041] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0042] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0044] Take the following ingredients for the recipe

[0045] propolis 8g sucrose 49g starch 34g Polyvinylpyrrolidone 4g

[0046] Prepare pellet formulations as follows:

[0047] (1) Take the amount of propolis in the above formula, add sucrose and starch, grind it to a micronized level with a ball mill, and mix well;

[0048] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0049] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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PUM

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Abstract

The invention provides a propolis pellet preparation. The pellet preparation is prepared from propolis and pharmaceutical adjuvants and is characterized in that the pharmaceutical adjuvants include an excipient and an adhesive; the weight percentages of the propolis, excipient and adhesive in the pellet preparation are respectively 5-20%, 70-85% and 1-5%. The pellet preparation has high dissolution rate and bioavailability. A preparation method is simple and convenient and is easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a propolis pellet and a preparation method thereof. Background technique: [0002] At present, propolis-related products are well received by consumers. They are basically ordinary tablets and capsules. Irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are generally added during the preparation of pellet preparations ["Design and Development of Sustained and Controlled Release Preparations", Yan Yaodong et al., Chinese Medicine Scien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61K9/16A23L1/29A23L1/076A23P1/00A23L21/20A23L33/00
Inventor 不公告发明人
Owner JF PHARMALAND TECH DEV
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