Method for extracting dioscorea nipponica

An extraction method and a technology for Pangosaurus, applied in the field of extraction of Pseudomonas, can solve the problems of long production cycle, high energy consumption for concentration, low extraction efficiency, etc., and achieve the effect of full utilization and high extraction efficiency.

Active Publication Date: 2015-06-24
TIANJIN UNIV
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Problems solved by technology

[0003] Chinese patent application No. 200410086729.1 discloses "a freeze-dried powder injection of Chugopus chinensis and its preparation method". The method adopts ultrasonic water extraction, ethanol precipitation and macroporous resin purification to extract and purify Chugoshangosaurus to obtain effective parts. The amount of solvent used It is 18 to 32 times that of medicinal materials, the amount of solvent used is large, and the energy consumption of subsequent concentration is high
Chinese Patent Application No. 200410097160.9 "Chuanshanlong Dropping Pills and Its Preparation Method" and the Ministry of National Drug Standard WS 3 - Chuanshanlong injection prepared in B-3283-98, wherein the extraction process of Chuanshanlong adopts the hot-dipping extraction method. During the extraction process, with the increase of time, the mass transfer driving force between the extract and the medicinal material gradually decreases, and the extraction The extraction efficiency is reduced and the solvent consumption is large, the energy consumption is high during concentration, and the entire production cycle is long
In addition, in order to fully extract the active ingredients, it is often necessary to extract 2 to 3 times, and the volume of the resulting extract is large, and the subsequent concentration time is long, energy consumption is large, and the cycle is long, etc.

Method used

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  • Method for extracting dioscorea nipponica

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Embodiment 1

[0015] A method for extracting pangosaurus, comprising the following steps: in the extraction tank 2 of the solvent circulation extraction single-effect concentration unit, immerse 20Kg of coarsely crushed pangosaurus in 100L of water for 14 hours, heat, and after the temperature reaches 95-100°C, open the extraction The discharge valve of the tank and the feed valve of the reboiler 11 allow the extract to enter the reboiler 11 and the evaporator 14, and when the liquid level reaches 1 / 3 to 1 / 2 of the height of the reboiler 11, close the inlet material valve, heat the reboiler 11, make the extract evaporate and concentrate in the reboiler and evaporator, the steam generated enters the cooling tower, condenses into hot water, and the hot water is returned to the extraction tank through the pump 16, and after the backflow starts, Adjust the vacuum degree, the discharge valve of the extraction tank and the feed valve of the reboiler 11, and control the reflux rate under the condit...

Embodiment 2

[0018] A method for extracting pangosaurus, comprising the following steps: in the extraction tank 2 of the solvent circulation extraction single-effect concentration unit, soak 20Kg of the coarsely crushed pangosaurus in 140L of water for 10 hours, heat, and after the temperature reaches 95-100°C, open the extraction The discharge valve of the tank and the feed valve of the reboiler 11 allow the extract to enter the reboiler 11 and the evaporator 14, and when the liquid level reaches 1 / 3 to 1 / 2 of the height of the reboiler 11, close the inlet material valve, heat the reboiler 11, make the extract evaporate and concentrate in the reboiler and evaporator, the steam generated enters the cooling tower, condenses into hot water, and the hot water is returned to the extraction tank through the pump 16, and after the backflow starts, Regulate the vacuum degree, the discharge valve of the extraction tank and the feed valve of the reboiler 11, and control the reflux velocity under the...

Embodiment 3

[0021] An extraction method of pangosaurus, comprising the steps of: soaking 20Kg of roughly pulverized pangosaurus in 120L of water for 12h in the extraction tank 2 of the solvent circulation extraction double-effect concentration unit, heating, and controlling the reflux rate to 0.7L / min (reflux rate=1.44 times the initial water addition / 4h), reflux for 4h, collect the extract, and concentrate under reduced pressure to 60°C when the relative density is 1.07, add ethanol after letting it cool, stir fully, so that the volume concentration of ethanol is 70%, statically Set aside for 12 hours, filter out the precipitate, and recover the ethanol from the filtrate under reduced pressure to obtain the pangosaurus extract.

[0022] The amount of diosgenin that can be obtained per g of raw medicinal materials is 7.4mg.

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Abstract

The invention discloses a method for extracting dioscorea nipponica. The method comprises the following steps: in an extracting tank of a solvent circulation extraction double-effect condenser set or a solvent circulation extraction single-effect condenser set, performing coarse grinding on the dioscorea nipponica according to the ratio of 1g:(5-7)ml, immersing in the water for 10-14h, heating, refluxing for 3.5-4.5h when the refluxing speed is 1.3-1.5 times of the initial water adding amount/(3.5-4.5)h, collecting the extract solution, decompressing and condensing, cooling, adding ethanol, fully stirring, standing, filtering to remove the precipitate, decompressing the filtrate, and recovering the ethanol to obtain the dioscorea nipponica extract. By adopting the method, the extracting efficiency of the dioscin is high and the dioscorea nipponica material is sufficiently utilized. The dioscorea nipponica is extracted under the technological parameter so that 7.3-7.6mg of the dioscin can be obtained in per gram of the dioscorea nipponica medicinal material.

Description

Technical field [0001] The invention involves the method of extracting the effective ingredients of the plant, especially the extraction method of a pangolin. Background technique [0002] The dragon through mountain dragon, wearing a dragon potato -meal -potato -chorine -diring potato 蓣 Dioscoreanipponica Makino's rhizome. It mainly contains a variety of saponins such as potato sauce, which has the effects of relieving muscles and promoting blood circulation, cough and phlegm, and removing wind and pain.Potatoscin in the dragon dragon has good analgesic and anti -perverted effects, which can improve immunity.Therefore, with a pangolin dragon as the raw material, the research of potato sauce extraction has high value. [0003] The Chinese patent application number is 200410086729.1 "A Mountain Drimble Dry Dried Powder injection and its preparation method". This method uses ultrasonic extraction, ethanol precipitation, and large -hole resin purification method to extract and purif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P29/00A61P37/04
Inventor 蒋建兰曹颂
Owner TIANJIN UNIV
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