Acanthopanax senticosus extract and preparation method thereof

A technology of Acanthopanax senticosus extract and Acanthopanax senticosus, which is applied in the directions of pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc., and can solve the problem that the extract preparation is unstable, cannot effectively remove impurities such as macromolecules, and is easily oxidized. Decomposition and other problems, to achieve the effect of reducing the loss of active ingredients, improving the yield, and achieving good results

Inactive Publication Date: 2015-07-01
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is a simple purification method and cannot effectively remove impurities such as macromolecules
[0011] Most of the researches on Acanthopanax senticosus are to remove a large number of unstable macromolecular compounds in the extract, such as tannins, resins, pigments, etc., and these macromolecular compounds are easy to be oxidized and decomposed, which is also the reason why the Acanthopanax senticosus extract and One of the reasons for the instability of its preparation
In the prior art, the research on using DM1180 resin to prepare Acanthopanax senticosus extract has not been reported. If the corresponding technology can be developed, there will be huge application prospects and economic value

Method used

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  • Acanthopanax senticosus extract and preparation method thereof
  • Acanthopanax senticosus extract and preparation method thereof
  • Acanthopanax senticosus extract and preparation method thereof

Examples

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Embodiment 1

[0075] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0076] In the present embodiment, the preparation method of Acanthopanax senticosus extract comprises the following steps:

[0077] (1) Extraction: extract 6 kg of Acanthopanax senticosus medicinal material with 12 times the volume of water (72L) for 3 times, extract for 1 hour each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, and set aside;

[0078] (2) One-time alcohol precipitation: under stirring conditions, add 95% ethanol (to make the alcohol content reach 75%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, and let stand for 6 hours; filter, and the filtrate Recover the ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.13 (measured at 80°C), and obtain the primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is ready for use;

[0079] (3) Macroporo...

Embodiment 2

[0083] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0084] In the present embodiment, the preparation method of Acanthopanax senticosus extract comprises the following steps:

[0085] (1) Extraction: extract 8 kg of Acanthopanax senticosus medicinal material twice with 8 times the volume of water (64 L), extract for 2 hours each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, and set aside;

[0086] (2) One-time alcohol precipitation: under stirring conditions, add 93% ethanol (to make the alcohol content reach 74.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, let stand for 12 hours, filter, and the filtrate Recover ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.11 (measured at 80°C), and obtain the primary alcohol precipitation paste of Acanthopanax acanthopanax extract, which is ready for use;

[0087] (3) Macroporous resin ...

Embodiment 3

[0091] Example 3: Preparation of Acanthopanax Acanthopanax Extract

[0092] In the present embodiment, the preparation method of Acanthopanax senticosus extract comprises the following steps:

[0093] (1) Extraction: extract 10 kg of Acanthopanax senticosus medicinal material twice with 12 times the volume of water (120L), extract for 1.5 hours each time, combine the extracts, concentrate, and obtain Acanthopanax senticosus water decoction, and set aside;

[0094] (2) One-time alcohol precipitation: under stirring conditions, add 95% ethanol (to make the alcohol content reach 75.5%) to the Acanthopanax senticosus water decoction obtained in step (1), stir well, let stand for 18 hours, filter, and the filtrate Recover the ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.14 (measured at 80°C), and obtain the primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is ready for use;

[0095] (3) Macroporous re...

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Abstract

The invention relates to a preparation method of an acanthopanax senticosus extract, and the acanthopanax senticosus extract prepared by the preparation method and a preparation comprising the acanthopanax senticosus extract. The preparation method comprises the following steps: acanthopanax senticosus water decocted extract paste prepared by water extract of an acanthopanax senticosus medicinal material is precipitated by alcohol, then pass through macroporous resin for adsorption and elution, eluent is concentrated, then again precipitated by alcohol, and is refined to obtain the acanthopanax senticosus extract; the refining method comprises use of DM1180 resin for adsorption, elution and secondary ultrafiltration of the eluent. The method provided by the invention can significantly reduce the content of impurities and especially nonpolar invalid impurities in the acanthopanax senticosus extract, improve the purity of effective components in the acanthopanax senticosus extract and security and stability of the acanthopanax senticosus extract, can reduce energy consumption, greatly improves the extract yield, is superior in effect compared with the method in the prior art, and has great application prospect and market value.

Description

technical field [0001] The present invention relates to the field of medicinal plant extraction, in particular to a preparation method of Acanthopanax senticosus extract, and the Acanthopanax senticosus extract obtained by the preparation method and a preparation containing the Acanthopanax senticosus extract. Background technique [0002] Acanthopanax is the dry root and rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of Araliaceae. It has the effects of invigorating qi, invigorating the spleen, invigorating the kidney and calming the nerves. Sexually pungent, slightly bitter, warm. It is used for spleen and lung qi deficiency, physical weakness and fatigue, loss of appetite, lung and kidney deficiency, chronic cough and shortness of breath, kidney deficiency, waist and knee pain, insufficiency of heart and spleen, insomnia and dreaminess. [0003] The main active ingredients in Acanthopanax are flavonoids, saponins and polysaccharides, and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254
Inventor 方同华许照芹刘玉成陈景超曾向东席桂才
Owner HARBIN ZHENBAO PHARMA
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