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Series salts of robenidine and application thereof in preparation of animal feeding growth promoter

A technology of chlorhexenidine and series of salts, which is applied in the preparation of growth promoters for animal feed, in the field of chlorhexidine series of salts, to achieve the effects of improved production performance, obvious production performance and broad market prospects

Inactive Publication Date: 2015-07-01
GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many antibiotic growth promoters have been or will soon be banned due to resistance transmission issues

Method used

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  • Series salts of robenidine and application thereof in preparation of animal feeding growth promoter
  • Series salts of robenidine and application thereof in preparation of animal feeding growth promoter
  • Series salts of robenidine and application thereof in preparation of animal feeding growth promoter

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] Preparation of Chlorhexenidine.R Salt

[0022]

[0023] Wherein R is DL-lactic acid, methanesulfonic acid, 2-hydroxyethylsulfonic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid or oxalic acid.

Embodiment 1

[0024] Example 1: Preparation of Robennidine 2-hydroxypropanoic acid / chlorhexenidine.DL-lactate

[0025] Get 1.4g of free chlorhexidine, add 8ml 95% ethanol, stir at room temperature, add 0.4g DL-lactic acid, stir for 2h, filter, filter cake is washed with 95% ethanol, washed with water, then dried overnight at 45°C to obtain the product (chlorobenzene Guanidine. DL-Lactate). δH(DMSO,500MHz)δ8.043(2H,s), δ7.791-7.808(4H,d), δ7.420-7.437(4H,d), δ6.691(2H,s), δ4.011- 4.052(1H,m),δ1.225-1.239(3H,d).

Embodiment 2

[0026] Embodiment 2: Preparation of Robennidine.methanesulfonic acid / chlorhexenidine.methanesulfonic acid salt

[0027] Get 1.4g of free chlorhexidine, add 8ml of 95% ethanol, stir at room temperature, add 0.4g of methanesulfonic acid, stir for 2h, filter, filter cake is washed with 95% ethanol, washed with water, then dried overnight at 45°C to obtain the product (chlorobenzene Guanidine. Mesylate). δH(DMSO,500MHz)δ12.098(2H,s), δ8.596(2H,s), δ8.355(2H,s), δ7.969-7.986(4H,d), δ7.550-7.567( 4H,d), δ2.430(3H,s).

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Abstract

The invention discloses series salts of robenidine and an application thereof in preparation of an animal feeding growth promoter. The series salts of robenidine have a structural formula shown in the formula (1), wherein R is DL-lactic acid, methanesulfonic acid, 2-isethionic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid or oxalic acid. Through feeding experiments, the research, for the first time, discovers that after application of the series salt compounds of robenidine, the production performance of ducks is improved obviously. Through animal feeding experiments, the research also discovers that after application of the series salt compounds of robenidine, the production performance of sows and hens is improved.

Description

Technical field: [0001] The invention belongs to the field of animal feed for livestock and poultry, and in particular relates to a series of salts of prohexidine and its application in the preparation of growth promoters for animal feeding. Background technique: [0002] Feed growth promoters include biologically active substances with various chemical structures and their preparations with multiple mechanisms of action, which make an important contribution to improving feed conversion rate and animal husbandry production efficiency. However, many antibiotic growth promoters have been banned or will soon be banned due to the problem of resistance transmission. [0003] Therefore, how to screen safe and efficient feed growth promoters that have no human medical use and no cross-resistance to human antibiotics, especially non-antibiotic and non-hormonal feed growth promoters is a problem. This study solved this problem. [0004] Chlorhexidine hydrochloride is traditionally ...

Claims

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Application Information

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IPC IPC(8): C07C281/18A23K1/16
Inventor 彭险峰覃宗华
Owner GUANGZHOU INSIGHER BIOTECHNOLOGY CO LTD
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