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Lavender essential oil liposome and preparation method thereof

A technology of lavender essential oil and nano-liposome, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of no lavender essential oil, no lavender essential oil, etc., to improve absorption utilization and increase stability , the effect of expanding the scope of application

Inactive Publication Date: 2015-07-29
YANGTZE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of nano-liposome technology in the cosmetics and food industries has achieved good results, such as a snake oil nano-liposome preparation and its preparation process (patent number: 200610011811.7), a vitamin A liposome and its preparation method (patent number: 02111967.8), etc., but in the development and utilization of lavender essential oil, so far, there is no report about lavender essential oil nano-liposome at home and abroad, and there is no lavender essential oil nano-liposome product on the market

Method used

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  • Lavender essential oil liposome and preparation method thereof
  • Lavender essential oil liposome and preparation method thereof

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preparation example Construction

[0022] A kind of preparation method of lavender essential oil nano-liposome provided by the invention comprises the following steps:

[0023] (1) Preparation of the organic phase: measure lavender essential oil, lecithin, cholesterol, and antioxidants according to the formula, add them to absolute ethanol at 40°C to 60°C, and fully dissolve;

[0024] (2) Preparation of the aqueous phase: fully dissolve Tween 80 in PBS buffer, wherein the mass percentage of Tween 80 is 0.5% to 5%;

[0025] (3) Preparation of liposome suspension: at a constant temperature of 40°C to 60°C, use a magnetic stirrer to continuously stir the organic phase prepared in step (1), and then use a syringe according to the volume ratio of the aqueous phase to the organic phase. Inject the aqueous phase into the organic phase at a ratio of 1 to 8:2 and continue to stir for 0.5 to 1 hour to obtain the lavender essential oil nanoliposome suspension;

[0026] (4) Removal of ethanol: move the lavender essential ...

Embodiment 1

[0034] Weigh soybean lecithin 200mg, cholesterol 4mg, lavender essential oil 100mg, vitamin A 10mg, dissolve in 10mL 40°C absolute ethanol to obtain an organic phase, place it on a constant temperature magnetic stirrer and stir continuously; weigh Tween 8020mg and dissolve it in 10mL 0.01mol In the PBS buffer solution of / L, obtain aqueous phase; Inject gained aqueous phase in the organic phase that constantly stirs with syringe, promptly obtain lavender essential oil nano liposome suspension, continue stirring 0.5h; Then suspension is moved in the flask, Ethanol was removed by rotary evaporation under reduced pressure on a rotary evaporator; finally, the suspension was squeezed through a 0.1 μm mixed cellulose ester microporous filter membrane with nitrogen gas once to obtain lavender essential oil nanoliposomes.

Embodiment 2

[0036] Weigh egg yolk lecithin 200mg, cholesterol 8mg, lavender essential oil 20mg, vitamin E 10mg, dissolve in 10mL 50°C absolute ethanol to obtain an organic phase, place it on a constant temperature magnetic stirrer and stir continuously; weigh Tween 8030mg and dissolve it in 10mL 0.05mol In the PBS buffer solution of / L, obtain aqueous phase; Inject gained aqueous phase in the organic phase that constantly stirs with syringe, promptly obtain lavender essential oil nano liposome suspension, continue stirring 0.5h; Then suspension is moved in the flask, Ethanol was removed by rotary evaporation under reduced pressure on a rotary evaporator; finally, the suspension was squeezed through a 0.15 μm polyvinylidene fluoride microporous filter membrane with helium for 5 times to obtain lavender essential oil nanoliposomes.

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Abstract

The invention provides a lavender essential oil nanometer liposome which is prepared from the following components in percentage by weight: 1-30% of lavender essential oil, 30-75% of lecithin, 3-20% of cholesterol, 5-40% of Tween 80 and the balance of an anti-oxidant. In the lavender essential oil nanometer liposome, the content of the lavender essential oil accounts for 1-30% of solid substances, the average particle diameter is smaller than 200 nm, and the encapsulation rate can reach 90-98%. The invention further provides a preparation method of the lavender essential oil nanometer liposome. The lavender essential oil nanometer liposome is prepared according to an ethanol injection-filtration film extrusion technology, so that the stability of the lavender essential oil is enhanced, the solubility of the lavender essential oil nanometer liposome is improved, bioactive ingredients in the lavender essential oil are effectively protected, the absorption effect and bioavailability of the lavender essential oil are improved, the quality of the lavender essential oil is improved, and the application rage of the lavender essential oil nanometer liposome is enlarged.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a lavender essential oil liposome and a preparation method thereof. Background technique [0002] Lavender essential oil is rich in aroma, elegant and fragrant. It is known as the "King of Spices" and is an important essence raw material in the world today. The chemical composition of lavender essential oil is complex. It not only contains many aroma components but also contains a large number of medicinal components, mainly containing linalool, linalyl acetate, 4-terpineol, lavender acetate and other components. The types of compounds are acetate, alcohol , mainly olefin compounds. It is these ingredients that promote blood circulation, enhance immunity and functional vitality, relax digestive tract spasm, cool and refresh, eliminate flatulence, help digestion, prevent nausea and dizziness, relieve anxiety and nervous migraine, prevent colds and many other benefits. The use ...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/14A61Q19/00
Inventor 丁保淼
Owner YANGTZE UNIVERSITY
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