Coumarin compounds, and preparation method and application thereof

A technology of coumarins and compounds, applied in chemical instruments and methods, compositions for inhibiting chemical changes, organic chemistry, etc., can solve the problem of little research on the chemical components of the extraction process
CN104945408AInactive Publication Date: 2015-09-30GUANGXI UNIV FOR NATITIES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGXI UNIV FOR NATITIES
Publication Date
2015-09-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses coumarin compounds. The preparation method comprises the following steps: extracting from rattan of Derris eriocarpa How by the inventor; according to the detection introduction of thin-layer chromatography, carrying out reversed-phase silica gel column chromatography, carrying out gradient elution by a petroleum ether-ethyl acetate system for further systematic separation, and recrystallizing. The antioxidation activity experiment proves that the compounds 1 have favorable antioxidation actions, the IC50 value for superoxide anion removal activity is less than that of the positive drug control ascorbic acid, the IC50 value DPPH.free radical removal activity has no great difference from the positive drug, and the compounds 1 have excellent antioxidation activity as compared with the coumarin compounds 6,7-dihydroxycoumarin, daphnetin and daphnoretin which are reported in documents. Therefore, the coumarin compounds disclosed by the invention can be used as a pharmaceutical or non-pharmaceutical antioxidant and the like.
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Description

technical field

[0001] The invention belongs to the technical field of new compounds, and in particular relates to a coumarin compound and its preparation method and application. Background technique

[0002] Derris eriocarpa How is the dried root and vine of the leguminous plant Derris eriocarpa How, also known as "Spatholobus Spatholobus" and "Licorice vine" etc. It is distributed in Guangxi and Yunnan. Its roots and stems are used as medicine; the stems are brownish yellow, with many xanthoma-like protrusions, and the cross-section is light yellow and fibrous. Deerwort trichome has diuretic and dehumidifying effects, antitussive and phlegm-relieving effects, and is often used in Guangxi Zhuang folk prescriptions, such as treating cystitis, nephritis, urethritis, cough and other symptoms. Because of its remarkable curative effect of folk medicine, it has attracted the attention of more and more researchers.

[0003] Free radicals are intermediate metabolites of various b...

Claims

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