Coumarin compounds, and preparation method and application thereof

A technology of coumarins and compounds, applied in chemical instruments and methods, compositions for inhibiting chemical changes, organic chemistry, etc., can solve the problem of little research on the chemical components of the extraction process

Inactive Publication Date: 2015-09-30
GUANGXI UNIV FOR NATITIES
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  • Abstract
  • Description
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Problems solved by technology

At present, the research on the cane of pichocarpus includes resource investigation, identification of medicinal material properties, thin layer, and ultraviolet spectrum, and research on pharmacology and toxicology such as anti-inflammatory and anal...

Method used

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  • Coumarin compounds, and preparation method and application thereof
  • Coumarin compounds, and preparation method and application thereof
  • Coumarin compounds, and preparation method and application thereof

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Embodiment Construction

[0020] 1. Preparation of Compound 1

[0021] Dried the canes of Deeria trichomes and crushed them, extracted the crushed Deeris trichomes with a 1L round bottom flask, added 10 times the volume of 95% ethanol, extracted in a water bath at 80°C for 2 hours, and extracted 3 times , filter, merge filtrate, repeat above-mentioned operation, extract the amount 10.5kg of pulverized Deeria trichocarpa altogether, and filtrate decompression concentration drying obtains extract 1.05kg;

[0022] The obtained extract was repeatedly extracted with petroleum ether, combined and concentrated to obtain 25.5 g of petroleum ether layer extract;

[0023] The petroleum ether layer extract is subjected to reversed-phase silica gel column chromatography separation, using petroleum ether-ethyl acetate system (gradient eluent is volume ratio (V / V) 10:0, 10:1, 10:3 , 10:4, 10:5 petroleum ether-ethyl acetate mixture) for gradient elution, collected, after thin layer chromatography (TLC), 365nm, 25...

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Abstract

The invention discloses coumarin compounds. The preparation method comprises the following steps: extracting from rattan of Derris eriocarpa How by the inventor; according to the detection introduction of thin-layer chromatography, carrying out reversed-phase silica gel column chromatography, carrying out gradient elution by a petroleum ether-ethyl acetate system for further systematic separation, and recrystallizing. The antioxidation activity experiment proves that the compounds 1 have favorable antioxidation actions, the IC50 value for superoxide anion removal activity is less than that of the positive drug control ascorbic acid, the IC50 value DPPH.free radical removal activity has no great difference from the positive drug, and the compounds 1 have excellent antioxidation activity as compared with the coumarin compounds 6,7-dihydroxycoumarin, daphnetin and daphnoretin which are reported in documents. Therefore, the coumarin compounds disclosed by the invention can be used as a pharmaceutical or non-pharmaceutical antioxidant and the like.

Description

technical field [0001] The invention belongs to the technical field of new compounds, and in particular relates to a coumarin compound and its preparation method and application. Background technique [0002] Derris eriocarpa How is the dried root and vine of the leguminous plant Derris eriocarpa How, also known as "Spatholobus Spatholobus" and "Licorice vine" etc. It is distributed in Guangxi and Yunnan. Its roots and stems are used as medicine; the stems are brownish yellow, with many xanthoma-like protrusions, and the cross-section is light yellow and fibrous. Deerwort trichome has diuretic and dehumidifying effects, antitussive and phlegm-relieving effects, and is often used in Guangxi Zhuang folk prescriptions, such as treating cystitis, nephritis, urethritis, cough and other symptoms. Because of its remarkable curative effect of folk medicine, it has attracted the attention of more and more researchers. [0003] Free radicals are intermediate metabolites of various b...

Claims

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Application Information

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IPC IPC(8): C07D493/04A61P39/06C09K15/06
CPCC07D493/04C09K15/06
Inventor 杨立芳肖汉王凯姜明国尹显洪向兰刘洪存梁行谢华恒冼丹丹
Owner GUANGXI UNIV FOR NATITIES
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