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Fenofibric acid tablet and preparing method thereof

A technology of fenofibric acid tablets and fenofibric acid, which is applied in the field of medicine, can solve problems such as the use amount and variety of excipients, low solubility of fenofibric acid, and unsatisfactory bioavailability, so as to improve drug compliance and shorten the The production cycle and the effect of improving the dissolution rate of the product

Inactive Publication Date: 2015-12-16
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Chinese patent CN201310039397 discloses an enteric-coated tablet of fenofibric acid and its physiologically acceptable salt and its preparation method. This method is not only complicated in the amount and variety of excipients, but also has the disadvantages of cumbersome preparation steps and high cost.
[0004] The solubility of fenofibric acid in water and acid is low, and the solubility of fenofibric acid increases with the increase of pH, so fenofibric acid has a higher solubility in the small intestine area, but the existing fenofibric acid Shell acid enteric-coated tablets are not only complicated in excipients but also have unsatisfactory bioavailability

Method used

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  • Fenofibric acid tablet and preparing method thereof
  • Fenofibric acid tablet and preparing method thereof
  • Fenofibric acid tablet and preparing method thereof

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preparation example Construction

[0036] At the same time, in a typical implementation of the present invention, the preparation method of the above-mentioned fenofibric acid tablets includes the following preparation steps in order:

[0037] (1) Mix fenofibric acid, filler and disintegrant evenly;

[0038] (2) add adhesive to make soft material, granulate, and dry;

[0039] (3) After the dried granules are sized, a lubricant is added, mixed evenly, and compressed into tablets to obtain the fenofibric acid tablets.

[0040] The method is simple to operate and easy to implement, not only reduces the cost, but also has better dissolution rate of the prepared fenofibric acid tablets.

[0041] The specific implementation of each step in the preparation method of the above-mentioned fenofibric acid tablets will be given below.

[0042] Preferably, in the preparation method of the above-mentioned fenofibric acid tablets, the preparation step (1) further includes: passing the raw material drug and auxiliary materia...

Embodiment 1

[0047] Raw materials and ratio:

[0048]

[0049] Preparation Process:

[0050] (1) pass the raw and auxiliary materials through an 80-mesh sieve, and set aside;

[0051] (2) Take by weighing the fenofibric acid of prescription quantity, filler, disintegrant are divided into 20 equal parts respectively, add and mix in turn;

[0052] (3) adding an appropriate amount of binder, making soft material, granulating through a 24-mesh sieve, and drying in an oven at 40°C for 1 hour;

[0053] (4) Pass through a 24-mesh sieve for granulation, add an appropriate amount of lubricant, mix evenly, press into tablets, and check.

Embodiment 2

[0055] Raw materials and ratio:

[0056]

[0057] Preparation Process:

[0058] (1) pass the raw and auxiliary materials through an 80-mesh sieve, and set aside;

[0059] (2) Take by weighing the fenofibric acid of prescription quantity, filler, disintegrant are divided into 20 equal parts respectively, add and mix in turn;

[0060] (3) adding an appropriate amount of binder, making soft material, granulating through a 24-mesh sieve, and drying in an oven at 40°C for 1 hour;

[0061] (4) Pass through a 24-mesh sieve for granulation, add an appropriate amount of lubricant, mix evenly, press into tablets, and check.

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Abstract

The invention discloses a fenofibric acid tablet and a preparing method thereof. The fenofibric acid tablet is prepared from fenofibric acid, filler, a disintegrating agent, a lubricating agent and a proper amount of adhesive. According to the fenofibric acid tablet, the dissolution rate of the fenofibric acid is increased, the fenofibric acid has high solubility in the small intestine, the bioavailability of the fenofibric acid is improved, and the clinical effect is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a fenofibric acid tablet and a preparation method thereof. Background technique [0002] Fenofibric Acid Tablets is a tablet dosage form of Fenofibric Acid. Blood lipid-lowering drugs are blood lipid-regulating drugs derived from clofibrate, which can reduce blood low-density lipoproteins, cholesterol and triglycerides by inhibiting the formation of very low-density lipoproteins and triglycerides and simultaneously increasing their catabolism ; It also increases the generation of apolipoprotein A1 and A11, thereby increasing high-density lipoprotein. [0003] Chinese patent CN201310039397 discloses an enteric-coated tablet of fenofibric acid and its physiologically acceptable salt and its preparation method. This method is not only complicated in the amount and variety of excipients, but also has the disadvantages of cumbersome preparation steps and high cost. [0004] The sol...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/26A61K31/192A61P3/06
Inventor 孙小惠杨亚军
Owner KANGYA OF NINGXIA PHARMA
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