Preparation method of vitamin C fatty acid diester

A technology for vitamins and fatty acids, applied in the field of L-ascorbic acid diester and its preparation, can solve the problems of incompatibility, weak antioxidant capacity of tetraesters, etc., and achieves the improvement of antioxidant capacity, compatibility, and esterification reaction rate. Effect
CN105218494BActive Publication Date: 2017-05-31东方红西洋参药业(通化)股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
东方红西洋参药业(通化)股份有限公司
Publication Date
2017-05-31

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Abstract

The invention provides vitamin C aliphatic acid diester and a preparation method thereof and relates to L-ascorbic acid diester and a preparation method thereof. According to the vitamin C aliphatic acid diester, the problems that vitamin C monoester is difficulty compatible with medicines, and vitamin C tetraester is weak in oxidation resistance are solved. The structural formula of the vitamin C aliphatic acid diester is shown in the specification. The preparation method of the vitamin C aliphatic acid diester comprises the following steps: after vitamin C is mixed with ethyl acetate, adding pyridine and a phase transfer catalyst, dropwise adding fatty acyl chloride into a reaction system, maintaining the dropwise adding speed until the dropwise adding is finished, continuing to react to separate a water layer and an oil layer, washing with water, and evaporating to separate ethyl acetate, so as to obtain a colorless oily vitamin C aliphatic acid diester crude product; and (2) dissolving the colorless oily vitamin C aliphatic acid diester crude product by virtue of a methanol-water mixed solvent, cooling to separate a methanol layer and a product layer, and removing methanol and ethyl acetate, so as to obtain a pure product, namely the vitamin C aliphatic acid diester. According to the preparation method, the compatibility and the oxidation resistance of the vitamin C aliphatic acid diester are obviously enhanced, and the purity of the product is improved. The preparation method is used for preparing the vitamin C aliphatic acid diester.
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Description

technical field

[0001] The invention relates to an L-ascorbic acid diester and a preparation method thereof. Background technique

[0002] Vitamin C can control the peroxidation of free radicals, and has a preventive effect on aging, tumors, cardiovascular and other diseases related to free radicals. However, the defects of poor fat solubility and easy oxidative denaturation limit its application in liposomes and cosmetics. Compared with vitamin C, the solubility and compatibility of vitamin C ester have been improved. It is a new type of safe food additive and cosmetic additive with multiple functional properties such as anti-tumor, anti-aging, anti-biological oxidation, and scavenging free radicals in the body. .

[0003] At present, there are mainly two types of vitamin C esters, namely vitamin C monoester and vitamin C tetraester. Vitamin C monoester contains three hydroxyl groups in the mother nucleus molecule, so its fat solubility is not high, and it is prone to em...

Claims

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