Expandable implantable conduit

A catheter and expandable technology, applied in medical science, valves, instruments, etc., can solve problems such as uncomfortable catheters and long-term functionality that have not been proven

Active Publication Date: 2016-01-13
CARNEGIE MELLON UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, young children may rapidly outgrow the implanted catheter and may require reoperation and replacement
To date, only tissue-engineered catheters or valved catheter

Method used

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  • Expandable implantable conduit
  • Expandable implantable conduit
  • Expandable implantable conduit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: A first plastically deformable material that can be used in an implantable catheter

[0076] Figure 7A A stress / strain curve is depicted for a first plastically deformable material that can be used to fabricate a plastically deformable and implantable catheter. The material has an average yield strength of about 2.1 MPa and an ultimate tensile strength of about 5 MPa. The material also exhibited elastic deformation at yield strength, characterized by an average elastic modulus of about 5.9 MPa. In the portion of the stress / strain curve where the material transitions from the elastically deformable mode to the plastically deformable mode, the material exhibits an average 36% elongation over the original length at the point of yield stress. Since the extended region of the stress / strain curve exhibits plastic deformability as opposed to elastic deformability, such materials can be advantageously used for plastically deformable catheters that can expand to ...

Embodiment 2

[0077] Example 2: A second plastically deformable material that can be used in an implantable catheter

[0078] Figure 7B A stress / strain curve is depicted for a second plastically deformable material that can be used to fabricate a plastically deformable and implantable catheter. The material exhibited an average yield strength of about 1.7 MPa and an ultimate tensile strength of about 5.5 MPa. The material also exhibits elastic deformation at yield strength, characterized by an average elastic modulus of about 7.4 MPa. In the portion of the stress / strain curve where the material transitions from the elastically deformable mode to the plastically deformable mode, the material exhibits an average 24% elongation over the original length at the point of yield stress. Since the extended region of the stress / strain curve exhibits plastic deformability as opposed to elastic deformability, such materials can be advantageously used for plastically deformable catheters that can e...

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Abstract

An expandable valved conduit for pediatric right ventricular outflow tract (RVOT) reconstruction is disclosed. The valved conduit may provide long-term patency and resistance to thrombosis and stenosis. The valved conduit may enlarge radially and/or longitudinally to accommodate the growing anatomy of the patient. Further, a method is disclosed for the manufacture of the valved conduit based in part on a plastically deformable biocompatible polymer and a computer-optimized valve design developed for such an expandable valved conduit.

Description

[0001] claim priority [0002] This application claims priority to U.S. Provisional Application No. 61 / 851,487, filed March 8, 2013, entitled "Expandable Valve Conduit for Pediatric Right Ventricular Outflow Tract (RVOT) Reconstruction" The disclosure of said application is incorporated herein by reference in its entirety. Background technique [0003] Catheter selection for right ventricular outflow tract (RVOT) reconstruction presents a number of challenges in the treatment of congenital heart disease including tetralogy of Fallot with pulmonary atresia, truncus arteriosus, with Aortic displacement in pulmonary stenosis, congenital aortic stenosis / insufficiency, and variants of such conditions. Following the invention of cryopreservation methods in the early 1980s, and especially with the increased availability of use in a wide range of graft sizes, allografts have become the catheter of choice for physicians performing RVOT reconstruction procedures. In many instances, s...

Claims

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Application Information

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IPC IPC(8): A61F2/24
CPCA61F2250/006A61F2250/0007A61F2/2475A61F2210/0004A61F2220/0075A61F2250/0082A61F2002/30706A61F2/2415A61F2/2412A61F2/2418G05B19/4099G05B2219/42155
Inventor C·D·伯恩斯坦A·卡尔拉
Owner CARNEGIE MELLON UNIV
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