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Method for separating and extracting rheinic acid and emodin from anthraquinone compounds in rheum officinale

A technology of rhubarb anthraquinone and rhein, applied in the separation/purification of carboxylic acid compounds, quinone separation/purification, organic chemistry, etc., can solve the problems of low purity and low extraction efficiency, and achieve high extraction efficiency and high purity , easy operation and preparation effect

Inactive Publication Date: 2016-02-03
YU HAN
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Problems solved by technology

[0006] The purpose of the present invention is to provide a method for separating and extracting rhein and emodin from rhubarb with high extraction efficiency, convenience, simplicity, and easy operation. Ultrasonic extraction technology and the properties of anthraquinone compounds are used to design an extraction scheme to overcome the traditional water The extraction method has the disadvantages of low extraction efficiency and low purity to achieve the purpose of simple and efficient extraction of emodin and rhein. In order to achieve the above-mentioned purpose, the specific technical scheme adopted by the present invention is as follows

Method used

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Embodiment

[0017] 4. Extraction of total anthraquinone aglycones in rhubarb

[0018] Extraction and separation of anthraquinone aglycone in rhubarb: take 50 grams of rhubarb crude drug, grind it into coarse powder, put it in a glass container, add 30ml of 20% sulfuric acid, add 200ml of chloroform, reflux in water bath for 1h, filter out the leachate, and refill the dregs. Use the same method as above to extract once, filter out the immersion solution, combine 400ml of the extracted solution obtained twice, concentrate again, recover chloroform, and the remainder is 100ml. The remaining liquid was washed with distilled water, and the liquid was separated for 2 to 3 times until the pH of the chloroform layer was 6. At this time, the main compound in the chloroform layer was the total anthraquinones in rhubarb.

[0019] 5. Separation of rhein

[0020] The chloroform layer obtained above was extracted four times with 5% sodium bicarbonate solution, and the sodium bicarbonate solution was s...

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Abstract

The invention relates to the technical field of traditional Chinese medicine extraction, and specifically relates to a method for separating and extracting rheinic acid and emodin from anthraquinone compounds in rheum officinale. The anthraquinone compounds in rheum officinale mainly comprise rheinic acid, emodin, aloe-emodin, chrysophanol, physcion, and glycoside of physcion. Rheinic acid and emodin are widely used in the medicine field and have different properties and pharmacological effects. On the basis that the acid properties of rheinic acid and emodin are different, an alkaline substance is used to extract total anthraquinone compounds from rheum officinale, then a pH-gradient method is adopted to separate and extract rheinic acid and emodin from the total anthraquinone compounds, and then the rheinic acid and emodin are purified.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a method for separating and extracting rhein and emodin from rhubarb anthraquinone compounds. technical background [0002] Rhubarb is a commonly used traditional Chinese medicine, also known as General, Chuanjun, and Jinwen. It is the rhizome of Rheum Palmatum (Rheum Palmatum L), Tangut Rhubarb (R. tanguticum) or medicinal Rhubarb (R. officinale Baill). Rhubarb is cold in nature and bitter in taste, and has the effects of purging and attacking stagnation, clearing heat and purging fire, cooling blood and detoxifying, promoting blood circulation and removing blood stasis. It mainly contains anthraquinone compounds, which have a strong purging effect. Among them, the purging effect of glycosides is often stronger than that of corresponding aglycones. Aglycones are mainly anthraquinone derivatives, including chrysophanol, emodin, aloe-emo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C46/10C07C50/34C07C51/48C07C51/43C07C66/02
CPCC07C46/10C07C51/43C07C51/48
Inventor 于涵
Owner YU HAN
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