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Areca nut cataplasm, its preparation method and use

A kind of technology of poultice and betel nut, which is applied in the field of betel nut poultice and its preparation, and achieves the effect of improving medicinal value

Active Publication Date: 2018-08-10
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is the lack of deep processing and scientific development and utilization of betel nut resources

Method used

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  • Areca nut cataplasm, its preparation method and use
  • Areca nut cataplasm, its preparation method and use
  • Areca nut cataplasm, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of areca nut extract

[0033] The betel nut decoction pieces used in this example are produced in Hainan Province, and sliced ​​raw betel nut decoction pieces can be purchased from Kangmei Pharmaceutical Co., Ltd.

[0034] Areca nut extract taken as follows

[0035] Group 1: Areca nut extract

[0036] Get 5000 grams of betel nut decoction pieces, add 75% ethanol to reflux and extract twice, add 10 times the concentration of 75% ethanol according to the weight of the decoction pieces for the first time, reflux for 1 hour, filter and separate the filtrate; add the second time according to the weight of the decoction pieces 8 times the concentration of 75% ethanol, reflux for 0.5 hours, filter and separate the filtrate. The filtrates were combined, and the filtrate was concentrated under reduced pressure to a density of 1.05 g / mL for later use.

[0037] Group 2: Areca nut extract

[0038] Get 5000 grams of betel nut decoction pieces, add 80% eth...

Embodiment 2

[0041] Example 2 Preparation of betel nut cataplasm

[0042] Take an appropriate amount of carbomer (940), add water to fully swell before use, and make a 5% gel.

[0043] according to figure 1 and figure 2 The described flow process prepares betel nut cataplasm.

[0044] The materials used in this embodiment are as follows:

[0045] Group 4: betel nut cataplasm

[0046] Skeleton material: 50 parts of sodium polyacrylate (Viscomate NP-700); (American International Specialty Company)

[0047] Cross-linking agent: 2 parts of aluminum glycolate; (American International Specialty Company)

[0048] 20 parts of propylene glycol; (Tianjin Fuyu Fine Chemical Co., Ltd.)

[0049] Excipient: 20 parts of Carbomer (940); (Beijing Haidianhui Fine Chemical Factory)

[0050] Adhesive: 40 parts of polyvinylpyrrolidone; (Tianjin Damao Chemical Reagent Factory)

[0051] Moisturizing agent: 300 parts of glycerin; (Tianjin Damao Chemical Reagent Factory)

[0052] Cross-linking modifier...

Embodiment 3

[0073] Example 3 Quality inspection of betel nut cataplasm

[0074] 1) Agilent1260Infinity High Performance Liquid Chromatograph (Agilent Technologies, Inc., USA)

[0075] 2) Chromatographic conditions and system suitability experiment Chromatographic column: Diamonsil C18 (4.6mm×200mm, 5μm); mobile phase: 0.1% triethylamine aqueous solution (adjust pH to 6.5 with phosphoric acid)-[methanol-acetonitrile (20:30) ] (73:27); flow rate 1.0ml / min; detection wavelength 215nm; injection volume 20μl. The number of theoretical plates should not be less than 4000 based on the calculation of the arecoline peak.

[0076] 2) Preparation of reference substance solution Precisely weigh about 25.0325 mg of arecoline hydrobromide reference substance, put it in a 25ml volumetric flask, add 0.001mol / l phosphoric acid solution to dissolve and dilute to the mark, shake well, and obtain.

[0077] 3) Preparation of standard curve Precisely measure 200μl, 600μl, 1000μl, 2000μl, 6000μl and 8000μl ...

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Abstract

The invention provides areca nut cataplasm, a preparation method thereof and application thereof in preparing medicine for expelling parasites, resisting depression and refreshing. The areca nut cataplasm has the advantages that medicinal value of areca nut is increased, damage to the oral cavity caused by arecoline is avoided, concentration of blood and intracerebral medicine is improved, and effects, on expelling parasites, resisting depression and refreshing, of areca nut are enhanced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine. Specifically, it relates to a betel nut cataplasm and its preparation method and application. Background technique [0002] Betel nut (Areca catechu L) is a tropical plant widely cultivated in tropical regions, mainly cultivated in Hainan Province in my country. It is one of the main producing areas of betel nut in the world, and its planting area and output have reached a considerable number and scale. Betel nut is a plant of the palm family areca tree, and the utilization of its fruit (also known as betel nut) mainly includes medicinal and edible methods. Betel nut ranks first among the four major southern medicines. It is recorded in traditional Chinese medicine that it has the function of regulating qi and eliminating accumulation, and can treat symptoms such as food accumulation, stagnation of qi, abdominal pain and fullness, and constipation. Its seeds, peels, flowers, etc. ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K36/889G01N30/02A61P33/02A61P33/10A61P25/24
CPCY02A50/30
Inventor 姜涛乐智勇陈华师许冬瑾马兴田
Owner KANGMEI PHARMA
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