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High-simulation collagen spinal cord stent for people and preparation method thereof

A technology of spinal cord and collagen, which is applied in the field of highly simulated collagen spinal cord scaffolds and its preparation, can solve the problems of cell survival and growth limitation, influence, cell compatibility and surface characteristics, and achieve mature technology, rich sources, and promote effective The effect of ordered growth

Inactive Publication Date: 2016-03-09
THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, artificial synthetic materials such as polylactic acid, polyglycolic acid, lactic acid-glycolic acid copolymer, etc., can be mass-produced, and the physical strength of the material is easy to control, but artificial synthetic materials are not inherent components of the organism itself, and its cytocompatibility and The surface properties are completely different from the extracellular matrix in vivo, and the acidic environment formed after degradation may limit and affect cell survival and growth

Method used

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  • High-simulation collagen spinal cord stent for people and preparation method thereof
  • High-simulation collagen spinal cord stent for people and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 uses highly simulated collagen spinal cord support for people

[0036] Such as figure 1 , 2As shown, the high-simulation collagen spinal cord stent for human use includes a stent body 1, and the stent body 1 is equipped with components for growing the gray matter of the spinal cord, the thin tract, the wedge tract, the lateral corticospinal tract, the rubrospinal cord and the reticulospinal tract, and the side of the spinothalamus. The hollow area of ​​the bundle, the tectum of the spinal cord, the reticulospinal tract, the anterior corticospinal bundle, and the central canal; the hollow area 2 for growing the thin bundle and the wedge bundle is located in the upper half of the scaffold body 1; it is used for growing the gray matter of the spinal cord and the central canal The hollow area 3 of the tube is located at the central part of the bracket body 1;

[0037] Hollow area 4 for growing corticospinal lateral tracts, hollow area 5 for growing rubrospina...

Embodiment 2

[0041] The preparation of high simulation collagen spinal cord support for two people in embodiment

[0042] (1) Remove fascia, fat, muscle and blood vessels from animal tissues such as beef tendon or young pig skin rich in collagen, and then soak and degrease with NAOH (pH8.0) solution after repeated cleaning;

[0043] (2) Dissolve the degreased material in acetic acid solution at pH 5.0, stir and mix evenly, add complex protease at a mass ratio of 500:1, and stir repeatedly for 24 hours;

[0044] (3) After centrifuging at 100g for 10min, collect the supernatant, add NaCl and stir, collect the precipitate, add acetic acid again and stir evenly, repeat the above operation 3 times and dissolve the collagen in 0.01-0.1 acetic acid solution to obtain a 1-3% collagen solution .

[0045] (4) Accurately measure the main parameters of the human spinal cord at the thoracolumbar level according to literature and neurophysiological data, and conduct statistical processing and analysis;...

Embodiment 3

[0051] Embodiment Three people use the preparation of highly simulated collagen spinal cord scaffold

[0052] (1) Remove fascia, fat, muscle and blood vessels from animal tissues such as beef tendon or young pig skin rich in collagen, and then soak them in NAOH (pH10.0) solution to degrease after repeated cleaning;

[0053] (2) Dissolve the degreased material in an acetic acid solution at pH 6.5, stir and mix evenly, add the compound protease at a mass ratio of 1000:1, and stir repeatedly for 24 hours;

[0054] (3) After centrifuging at 100g for 10min, collect the supernatant, add NaCl and stir, collect the precipitate, add acetic acid again and stir evenly, repeat the above operation 3 times and dissolve the collagen in 0.01-0.1 acetic acid solution to obtain a 1-3% collagen solution .

[0055] (4) Accurately measure the main parameters of the human spinal cord at the thoracolumbar level according to literature and neurophysiological data, and conduct statistical processing ...

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Abstract

The invention provides a high-simulation collagen spinal cord stent for people. The stent comprises a stent body, and the stent body is internally provided with hollow regions used for growing spinal grey matter, fasciculus gracilis, fasciculus cuneatus, tractuscorticospinalislateralis, tractusrubrospinalis, a reticulospinal tract, a lateral spinothalamic tract, a spinotectal tract, a reticulospinal tract, a direct pyramidal tract and a central canal. The vertical diameter of the stent body is 1.2-1.8 cm, the transverse diameter of the stent body is 1.4-1.8 cm, and the height of the stent body is 2.0 mm-8 cm. The stent body is made of collagen. According to the high-simulation collagen spinal cord stent for people, the main anatomical structure and the spatial relationship of thoracolumbar horizontal spinal segment white and grey matter of people are established, the stent is used for improving nerve directional and orderly connection after spinal cord injury, and rapid repair is promoted after spinal cord injury of people.

Description

technical field [0001] The invention relates to a high-simulation collagen spinal cord support for rapid repair after human spinal cord injury and a preparation method thereof. Background technique [0002] Nerve regeneration after spinal cord injury (spinal cordinjury, SCI) is still a difficult problem for clinicians and researchers. Due to the obstruction of the local inhibitory biological microenvironment and physical environment in the acute stage of the injury site, the disordered growth of the neural network and limited nerve regeneration are caused. In recent years, with the development of neural tissue engineering, some progress has been made in spinal cord nerve regeneration. The main strategy is to adjust and control the local inhibitory microenvironment after SCI, while promoting and guiding the directional and orderly connection of local neural networks. However, even with the combination of current tissue engineering technology and biological methods, the numbe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61L27/22A61L27/54A61L27/58B33Y10/00B33Y50/00
CPCA61L27/222A61F2002/0086A61L27/54A61L27/58A61L2300/414A61L2430/32
Inventor 陈旭义李瑞欣涂悦张赛汤锋武程远驰杨凯卢磊朱祥潘红
Owner THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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