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Chinese herbal medicine compound preparation for treating gout

A technology of compound preparations and traditional Chinese medicines, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as damage, large side effects, and irreversible liver and kidney functions

Inactive Publication Date: 2016-03-23
TIANJIN JUXING TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of the above drugs has relatively large side effects, mainly irreversible damage to liver and kidney functions

Method used

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  • Chinese herbal medicine compound preparation for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Preparation of tablets: 50g of Chinese medicine extract, 100g of benzbromarone, 48g of lactose, 26g of microcrystalline cellulose, mix well, add appropriate amount of 10% PEG6000 solution to granulate, dry, then add 10g of sodium carboxymethyl starch, Magnesium stearate 1.5g, mixed evenly, compressed into tablets, film-coated. The traditional Chinese medicine extracts are: Fangji 10, Hovenia dulcis 15, Hongteng 3, Emlical 10, and Plantain 3, which are respectively pulverized into coarse powder, and respectively use 30% (w / w) of 5 times the weight of the materials Extract with ethanol or water twice; each time for 1 hour, filter, combine the filtrates, and set aside.

Embodiment 2

[0048] Chinese medicine extract 40g, benzbromarone 60g, add dextrin 100g, lactose 270g, granulate with pure water, dry, pack capsule, make 1000 capsules. The traditional Chinese medicine extracts are: Fangji 12, Hovenia dulcis Fructus 13, Red Teng 10, Emlical 8, and Plantain 10, which are respectively pulverized into coarse powder, and respectively use 35% (w / w) of 5 times the weight of the materials. Extract with ethanol or water twice; each time for 1 hour, filter, combine the filtrates, and set aside.

Embodiment 3

[0050] Chinese medicine extract 60g, benzbromarone 120g, Fangji 15, Hovenia dulcis 15, Red rattan 3, Emlical seed 6, Red rattan 3, Plantain 10.

[0051] Grind them into coarse powders, extract twice with 30% (w / w) ethanol or water in an amount 5 times the weight of the materials; filter each time for 1 hour, combine the filtrates, and set aside. Mix evenly, sieve, then mix with 300g of starch evenly, make granules with starch slurry (take 220g of starch to make starch slurry with water), sieve, dry, and pack into capsules.

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Abstract

The invention relates to a Chinese herbal medicine compound preparation for treating gout. The compound preparation is prepared from Chinese herb extract, benzbromarone and medicinal carriers acceptable in pharmacy, wherein the weight part ratio of the Chinese herb extract to the benzbromarone to the acceptable medicinal carriers is 1:(1-4):(2-10). The Chinese herb extract comprises 10-20 parts of stephania terandra, 15-30 parts of hovenia dulcis thunb, 3-8 parts of sargentgloryvine stems, 3-10 parts of emblic leafflower fruits and 3-10 parts of plantain herbs. A pharmacology experiment proves that the compound preparation has the obvious synergistic effect, the concentration of uric acid in serum can be rapidly reduced, and the gout treatment effect is remarkably improved; meanwhile, the medication dosage of each single component is greatly reduced, and the toxic and side effects of the medicinal materials are effectively reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gout, more specifically the invention relates to a compound Chinese medicine preparation for treating gout. Background technique [0002] Modern medicine has proved that gout is caused by a metabolic disorder of a substance called purine in the body. Clinically, it is characterized by recurrent acute arthritis, gout stones, increased blood uric acid concentration, joint deformities and kidney lesions. Gout is not a single disease, but a syndrome. It is a disease closely related to diet. In the past, it was considered as a disease of alcohol and meat and a disease of wealth. [0003] The most important biochemical basis of gout is hyperuricemia. A normal adult produces about 750 mg of uric acid per day, of which 80% is endogenous and 20% is exogenous uric acid. These uric acids enter the uric acid metabolic pool (about 1200 mg), and about 60% of the uric acid in the daily metabolic poo...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61P19/06
Inventor 李仁智
Owner TIANJIN JUXING TECH DEV CO LTD
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