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External preparation for skin

A technology for external preparations and skin, applied in the field of external preparations for skin, can solve problems such as incompatibility

Inactive Publication Date: 2016-04-20
苏州药基美研医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such oily topical preparations are not suitable for areas with high sebum production

Method used

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  • External preparation for skin
  • External preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Weigh out the pseudoceramide PC-102 (hydroxypropyl bislauramide MEA, corresponding to the compound of structure I in the figure, R 1 , R 2 All are 11-carbon straight chain alkyl groups) 100g, heated and melted in a reactor under an inert gas atmosphere (the jacket temperature is 90°C). Then add cholesterol 19.2g, cholesterol stearate 2.0g, stearic acid 14.3g, N-palmitoylethanolamine 5.0g, emulsifier SIMULSOL165 (Seppic company, compounded by glyceryl stearate and PEG-100 stearate) prepared) 10g. After heating for about 2 hours, add 200 g of purified water at 85 degrees Celsius, stir, emulsify, homogenize, and cool to room temperature to obtain an emulsion. Take 170 g of the emulsion, add 250 g of purified water, and stir evenly. Add glycerin 12g, tocopherol acetate 5g, SymRelief 1g (Symrise company product, compounded by bisabolol and ginger root extract), caprylyl glycol 1g, ethylhexylglycerol 0.5g, glycerol monocaprylate 3.5g, epigallocatechin gallate (EGCG) 5g. ...

Embodiment 2

[0045] Weigh out the pseudoceramide N-palmitoyl hydroxyproline cetyl ester (corresponding to the compound of structure IV in the figure, wherein R 1 For 15 carbon straight chain alkyl, R 2 50g of 16-carbon straight chain alkyl group), heated and melted in a reactor under an inert gas atmosphere (the jacket temperature is 90°C). Then add 10 g of cholesterol, 2.5 g of stearic acid, 2.5 g of palmitic acid, 1.5 g of N-palmitoylethanolamine, and 5 g of emulsifier MontanovL (Seppic company, compounded by C14-22 alcohol and C14-22 alkyl glucoside). After heating for about 2 hours, add 400 g of purified water at 85 degrees Celsius, stir, emulsify, homogenize, and cool to room temperature to obtain an emulsion. Add 25g of glycerol, 25g of tocopherol, 0.5g of SymRelief (product of Symrise, compounded by bisabolol and ginger root extract), 1g of peony root extract, 5g of linoleic acid, 1g of caprylyl glycol, ethyl Hexylglycerin 0.5g, glycerol monocaprylate 3.5g, disodium EDTA 0.5g. St...

Embodiment 3

[0047] Weigh out the pseudoceramide myristyl palmitoyl serine ester (PMS, corresponding to the compound of structure VIII in the figure, where R 1 For 15 carbon straight chain alkyl, R 2 30g of 14-carbon straight chain alkyl group), heated and melted in a micro-reactor under an inert gas atmosphere (the jacket temperature is 90°C). Then add cholesterol 7g, stearic acid 0.5g, palmitic acid 0.5g, N-palmitoylethanolamine 0.3g, emulsifier Montanov202 (Seppic company, compounded by eicosyl, behenyl alcohol and eicosyl glucoside prepared) 5g. After heating for about 2 hours, add 300 g of purified water at 85 degrees Celsius, stir, emulsify, homogenize, and cool to room temperature to obtain an emulsion. Add glycerol 5g, tocopherol 5g, SymRelief 0.5g (Symrise company product, compounded by bisabolol and ginger root extract), peony root extract 0.5g, linoleic acid 3g, linolenic acid 3g, caprylic acid Alcohol 1g, Ethylhexylglycerin 0.5g, Glycerin Monocaprylate 3.5g, Dipotassium Glyc...

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PUM

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Abstract

The invention discloses an external preparation for skin. The preparation comprises components including a pseudo-ceramide compound, a steroid, fatty acid and N-acylethanolamine and contains no grease. Through the manner, the preparation can be used for skin care and maintenance as well as treatment of some skin symptoms, particularly dermatitis symptoms such as atopic dermatitis, eczema, acne, seborrhoeic dermatitis, contact dermatitis, allergic dermatitis, solar dermatitis and the like, particularly in areas where sebaceous glands are abundant, such as faces, scalp, necks, chests, backs and buttocks.

Description

technical field [0001] The present invention relates to the field of skin care products, in particular to an external preparation for skin. Background technique [0002] The skin is the largest organ of the human body, with a weight of about 16% of the human body, and an adult area of ​​about 1.5 square meters. The skin is composed of epidermis, dermis and subcutaneous tissue, which is extremely important for the stability of the internal environment of the human body. The skin also includes various appendages, such as sebaceous glands, hair, sweat glands, nails, etc., as well as abundant blood vessels, lymphatic vessels, nerves and muscles. [0003] The epidermis is divided into basal layer, spinous layer, granular layer, transparent layer and stratum corneum from deep to superficial. One of the very important functions of the epidermis is the barrier function. When various dermatitis occurs, such as atopic dermatitis, eczema, seborrheic dermatitis, allergic dermatitis, ...

Claims

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Application Information

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IPC IPC(8): A61K31/164A61K31/201A61K31/202A61K31/575A61K31/16A61K31/045A61K31/047A61K31/704A61K31/566A61K31/355A61K31/4164A61K36/9068A61K8/97A61K8/42A61K8/49A61K8/63A61K8/36A61Q19/00A61P17/00A61P17/10A61P17/08A61P37/08
CPCA61K31/164A61K8/361A61K8/42A61K8/4913A61K8/63A61K8/97A61K31/045A61K31/047A61K31/16A61K31/201A61K31/202A61K31/355A61K31/4164A61K31/566A61K31/575A61K31/704A61K36/324A61K36/65A61K36/71A61K36/9068A61K2800/30A61Q19/00
Inventor 李维宽
Owner 苏州药基美研医药科技有限公司
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