Preparation method for high-sensitivity functionalized gold nanoparticle-doped meprobamate molecularly-imprinted electrochemical sensor

A gold nanoparticle, meprobamate technology, applied in the direction of electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of inappropriate matching of functional monomers and template molecules, low sensitivity, poor cross-linking rigidity, etc.

Inactive Publication Date: 2016-04-20
GUANGXI UNIV FOR NATITIES
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AI Technical Summary

Problems solved by technology

The current method is not sensitive because the selected functional monomers cannot be properly matched with the template molecules, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method for high-sensitivity functionalized gold nanoparticle-doped meprobamate molecularly-imprinted electrochemical sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of Meprobamate Molecularly Imprinted Electrochemical Sensor

[0017] To 10.0mL solvent ethanol, add 0.5mmol template molecule meprobamate, 5.0mmol functional monomer aminotadalafil, 3.8mmol crosslinking agent hydrocortisone acetate, 0.1mmol initiator azobis Isobutyronitrile and 0.0250g of dodecanethiol-functionalized gold nanoparticles were ultrasonically dissolved for 12 minutes each time a chemical reagent was added;

[0018] Take 6 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode with a diameter of 2 mm. The template molecules were eluted with a mixed solvent of ...

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Abstract

The invention discloses a preparation method for a high-sensitivity functionalized gold nanoparticle-doped meprobamate molecularly-imprinted electrochemical sensor. According to the method, meprobamate serves as a template molecule, aminotadalafil serves as a functional monomer, azodiisobutyronitrile serves as an initiating agent, dodecanethiol functionalized gold nanoparticles serve as a doping agent, hydrocortisone acetate serves as a cross-linking agent, and then the high-sensitivity dodecanethiol functionalized gold nanoparticle-doped meprobamate molecularly-imprinted electrochemical sensor is prepared. The analytical method is simple and practical, and the defects that an original analytical method is complex, expensive in equipment, and low in sensitivity are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a method for preparing a high-sensitivity functionalized gold nanoparticle-doped meprobamate molecularly imprinted electrochemical sensor. Background technique [0002] Meprobamate mainly treats anxiety neurosis, relieves symptoms such as anxiety, tension, restlessness, and insomnia, and can also treat diseases with hypertonia or muscle stiffness. However, because long-term or excessive use of such drugs can cause drug addiction problems or side effects such as drowsiness, kidney, lung, and liver function damage, and even cause fatal risks when the drug is suddenly stopped, it is listed as a controlled drug by most countries in the world . [0003] Methods for the determination of Meprobamate include ultraviolet spectroscopy, high performance liquid chromatography, and the like. However, these methods have the disadvantages of high cost, long time consumption, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 韦贻春余会成李浩雷福厚陈其锋谭学才
Owner GUANGXI UNIV FOR NATITIES
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