Traditional Chinese medicine composition for treating liver depression type hyperplasia of mammary glands and preparation method thereof

A technology of breast hyperplasia and composition, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problem of patients being prone to recurrent attacks, and achieve the effects of low cost, enhanced physical fitness, and high cure rate.

Inactive Publication Date: 2016-06-08
邢志博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

TCM preparations for the treatment of mammary gland hyperplasia include oral preparations and patches, but most patients ten

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) a kind of Chinese medicine for the treatment of hyperplasia of mammary glands due to liver depression, which is formed by proportioning by weight of the following raw materials:

[0034]30 parts of white peony, 25 parts of tortoise shell, 20 parts of Yuanhu, 15 parts of lotus seed heart, 15 parts of honeysuckle, 10 parts of dandelion, 10 parts of white dragon, 10 parts of grass jade plum, 10 parts of white plow grass, 5 parts of pig's tooth soap 5 servings of angelica.

[0035] (2) Preparation method:

[0036] In the first step, the tortoise shell and Yuanhu are mixed in proportion, and the n-propanol with an alcohol concentration of 70-80% equivalent to 2-3 times the mass of the mixture is refluxed for 2-4 times, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, then purified with ethanol for 1-2 times, combined extracts, recovered ethanol under reduced pressure and concentrated to a paste with a relative densit...

Embodiment 2

[0041] (1) a kind of Chinese medicine for the treatment of hyperplasia of mammary glands due to liver depression, which is formed by the proportioning by weight of the following raw materials: same as embodiment 1.

[0042] (2) Preparation method:

[0043] In the first step, the tortoise shell and Yuanhu are mixed in proportion, and the n-propanol with an alcohol concentration of 70-80% equivalent to 2-3 times the mass of the mixture is refluxed for 2-4 times, and the filtrates are combined, concentrated under reduced pressure, dried and pulverized into powder, then purified with ethanol for 1-2 times, combined extracts, recovered ethanol under reduced pressure and concentrated to a paste with a relative density of 1.21-1.24 at 60°C, dried and crushed into powder;

[0044] In the second step, the lotus seed heart, honeysuckle, dandelion, and Bailongchuancai are extracted 2-3 times with n-propanol with an alcohol concentration of 80-90%, and the extracts are combined, concentra...

Embodiment 3

[0048] 1. Long-term toxicity test process:

[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating liver depression type hyperplasia of mammary glands. The traditional Chinese medicine composition is prepared from radix paeoniae alba, tortoise shells, rhizoma corydalis, lotus plumule, honeysuckle flowers, dandelions, Panzeria alashanica Kupr, anemone rivularis, Viola alata Burgsd., fructus gleditsiae and radix angelica sinensis. The invention further discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the advantages of being good in treatment effect, low in cost, high in cure rate, free of adverse reaction and the like in the aspect of treating liver depression type hyperplasia of mammary glands. The traditional Chinese medicine composition can strengthen the physique of a patient, relieve depression, remove stasis, regulate meridians, remove stasis and eliminate mammary nodes, has the obvious abirritation effect and can be greatly applied to clinical practice.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine composition for treating hyperplasia of mammary glands due to liver depression and a preparation method thereof. Background technique [0002] Mammary gland hyperplasia belongs to the category of "breast addiction" in traditional Chinese medicine. It is a common disease and frequently-occurring disease among young and middle-aged women, accounting for more than 70% of breast diseases. Primary disease is comparatively common, and domestic report its sickness rate is about 10%, and occurs mostly in the women of 30-50 years old, although the man is rare, also has generation. Modern medicine believes that it is related to endocrine dysfunction, with breast pain and breast lumps as the main features. Traditional Chinese medicine believes that the cause of the disease is stagnation of liver qi, phlegm coagulation and blood stasis, and imbalance between Chong and ...

Claims

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Application Information

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IPC IPC(8): A61K36/86A61P15/14A61K35/586
CPCA61K36/71A61K9/0019A61K9/08A61K9/4866A61K35/586A61K36/232A61K36/288A61K36/355A61K36/483A61K36/53A61K36/62A61K36/65A61K36/66A61K36/80A61K36/86A61K47/02A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 邢志博王凤梅宫志华
Owner 邢志博
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