A particle size control method of superparamagnetic iron oxide microspheres

A technology of superparamagnetic iron oxide and microspheres, applied in the direction of iron oxide, iron oxide/iron hydroxide, nanotechnology for materials and surface science, etc., can solve problems such as complex methods, and achieve simple operation and practicability Good results

Inactive Publication Date: 2017-05-24
SANMING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The microemulsion method is a two-step method to construct microspheres. First, oil-soluble superparamagnetic iron oxide nanoparticles are synthesized by high-temperature thermal decomposition method, and then assembled into microspheres by oil-in-water microemulsion method. The particle size of the microspheres can be determined by The size of microemulsion micelles is controlled, which is more complicated

Method used

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  • A particle size control method of superparamagnetic iron oxide microspheres
  • A particle size control method of superparamagnetic iron oxide microspheres
  • A particle size control method of superparamagnetic iron oxide microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 0.14 g (2 mmol) of polyacrylic acid and 0.16 g (1 mmol) of anhydrous ferric chloride and dissolve them in 12 mL of ethylene glycol, stir to form a transparent solution, then add 3 mL of 3-aminopropanol dropwise under stirring , then add 20 μL of ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate, mix evenly, transfer to a hydrothermal synthesis reactor (20 mL) with polytetrafluoroethylene liner, seal it, and dry it in the air Keep the temperature in the box at 200°C for 6 h, and cool to room temperature with the furnace to obtain a black sol, add water to dilute, wash with the aid of a magnet to remove impurities, and vacuum dry to obtain a black powder.

[0027] The electron microscope photograph of the obtained product is as follows figure 1 As shown, the average particle size of the microspheres is 63 nm.

Embodiment 2

[0029] The method is the same as in Example 1, the volume of the ionic liquid added is 10 μL, and the electron micrograph of the resulting product is as follows: figure 2 As shown, the average particle size of the microspheres is 122 nm.

Embodiment 3

[0031] The method is the same as in Example 1, the volume of the ionic liquid added is 5 μL, and the electron micrograph of the resulting product is as follows: image 3 As shown, the average particle size of the microspheres is 165 nm.

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Abstract

The invention belongs to the preparation field of superparamagnetic iron oxide microspheres, and particularly relates to a grain size adjusting method of the superparamagnetic iron oxide microspheres.The grain size adjusting method includes: in the process of preparing the superparamagnetic iron oxide microspheres through a polyol method, adding ion liquid to change polarity of a system, adjusting grain size of microspheres obtained, and maintaining size of grains forming the microspheres unchanged to realize unitary adjusting; obtaining the superparamagnetic iron oxide microspheres of 60-250 nm in grain size and 5.5+ / -0.3 nm in granularity.The grain size adjusting method is simple and convenient to operate and high in practicability.

Description

technical field [0001] The invention belongs to the field of preparation of superparamagnetic iron oxide microspheres, and in particular relates to a particle size control method of superparamagnetic iron oxide microspheres. Background technique [0002] Superparamagnetic iron oxide microspheres have a wide range of applications in protein and nucleic acid purification, immunoassay, magnetic separation, nano drug loading and other fields. The magnetic properties, water dispersibility and other properties of superparamagnetic iron oxide microspheres are related to their particle size. The key to its synthesis is the control of the microsphere diameter. It is of great value to develop a simple synthesis technology that can precisely adjust the microsphere particle size. [0003] The preparation of superparamagnetic iron oxide microspheres mainly includes microemulsion method and polyol method. The microemulsion method is a two-step method to construct microspheres. First, oil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/06B82Y30/00
CPCC01G49/06C01P2002/72C01P2004/04C01P2004/62C01P2004/64
Inventor 肖旺钏周凌云罗菊香赵炎王仁章赖文忠
Owner SANMING UNIV
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