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Apparatus and methods for preparing biological samples for analysis

A technology for samples and equipment, applied in the field of equipment and methods for preparing biological samples for analysis, can solve the problems of lack and difficulty in processing multiple samples at the same time

Inactive Publication Date: 2017-09-19
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] May be difficult to process multiple samples simultaneously due to lack of simple and efficient setup required for this procedure

Method used

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  • Apparatus and methods for preparing biological samples for analysis
  • Apparatus and methods for preparing biological samples for analysis
  • Apparatus and methods for preparing biological samples for analysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach A

[0129] Embodiment A is a device comprising:

[0130] a body having a first end and a second end opposite the first end, the body comprising:

[0131] a processing chamber having an opening adjacent the first end;

[0132] a first reservoir in selective fluid communication with the processing chamber via a first fluid passage;

[0133] a second reservoir in selective fluid communication with the processing chamber via a second fluid passage;

[0134] a filter through which the first fluid passage and the second fluid passage pass, the filter having a first side oriented towards the processing chamber in the fluid passage and a second side opposite the first side side;

[0135] a first one-way valve disposed in the first fluid passage between the filter and the first reservoir, the first one-way valve between the processing chamber and the first reservoir provide selective fluid communication between; and

[0136] a second one-way valve disposed in the second fluid passage ...

Embodiment approach S

[0154] Embodiment S is an apparatus comprising:

[0155] a body having a first end and a second end opposite the first end, the body comprising:

[0156] A plurality of liquid sample processing modules, the plurality of liquid sample processing modules comprising a first module and a second module, wherein each module in the plurality of modules comprises:

[0157] a processing chamber having an opening adjacent the first end;

[0158] a first reservoir in selective fluid communication with the processing chamber via a first fluid passage;

[0159] a second reservoir in selective fluid communication with the processing chamber via a second fluid passage;

[0160] a filter through which the first fluid passage and the second fluid passage pass, the filter having a first side oriented towards the processing chamber in the fluid passage and a second side opposite the first side side;

[0161] a first one-way valve disposed in the first fluid passage between the filter and the...

Embodiment approach JJ

[0180] Embodiment JJ ​​is an apparatus comprising:

[0181] a body having a first end and a second end opposite the first end, the body comprising:

[0182] a plurality of processing chambers including a first processing chamber and a second processing chamber, each processing chamber having an opening adjacent the first end;

[0183] a first reservoir in selective fluid communication with the first processing chamber via a first fluid passage;

[0184] a second reservoir in selective fluid communication with the first processing chamber via a second fluid passage, and in selective fluid communication with the second processing chamber via a third fluid passage;

[0185] a first filter disposed in the body between at least a portion of the processing chamber and the second reservoir;

[0186] wherein the first fluid passage and the second fluid passage pass through the first filter;

[0187] wherein the first filter has a first surface oriented toward the first processing c...

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Abstract

An apparatus for processing a biological sample is provided. The apparatus includes a body having a processing chamber, a first reservoir, a second reservoir, a filter, a first one-way valve, a second one-way valve, a first fluid pathway, and a second fluid pathway. The first fluid pathway and the second fluid pathway pass through the filter. A method of processing a sample using the apparatus is also provided. The method includes placing a sample comprising a liquid into the processing chamber; urging at least a portion of the liquid through the filter; after urging the at least a portion of the liquid through the filter, urging a portion of a back-flush liquid through the filter into the process chamber to form a first processed sample; and analyzing at least a portion of the first processed sample to detect an indication of a microorganism.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application 61 / 915,124, filed December 12, 2013, the disclosure of which is incorporated herein by reference in its entirety. Background technique [0003] Many types of samples (such as clinical, environmental, food and beverage samples) are routinely tested for the presence of microorganisms. Specifically, various samples are tested to determine the presence of pathogenic microorganisms. Often, various types of pretreatment of the sample (i.e., treatment prior to the detection step) are required to increase the number of target microorganisms, reduce the number of non-target microorganisms, concentrate microorganisms, and / or reduce the amount of potentially interfering substances in the sample . The preprocessing steps can be laborious and can take hours to days to complete. Various materials and devices have been developed to reduce the number of steps and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/502B01L2200/0689B01L2300/0681B01L2300/0832B01L2300/087B01L2300/123B01L2400/0478B01L2400/0605B01L2400/0611C12Q1/24
Inventor 容·A·基施霍费尔格雷戈里·W·西顿安德鲁·H·蒂尔斯特拉
Owner 3M INNOVATIVE PROPERTIES CO
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