Tetracaine ethosome

Abstract

The invention discloses a tetracaine ethosome prepared from the following raw materials in percentage by weight: 0.3-5% of tetracaine, 1.0-5.0% of egg yolk lecithin, 30-80% of short chain alcohol and 14-68% of water. The tetracaine ethosome is a novel percutaneous agent carrier, has a novel mostly spherical or nearly spherical multicellular vesicle structure, has the characteristics of more stable thermodynamics, smaller particle diameter, high encapsulation rate up to 82.36%, faster and stronger percutaneous performance, good skin tolerance, lower dosage and the like, reduces the occurrence rate of adverse response, and improves the safety.

Description

technical field [0001] The invention relates to the field of medical anesthetics, in particular to a tetracaine ethosome. Background technique [0002] Transdermal Drug Delivery System (TD DS) is an effective drug delivery method for absorbing therapeutic drugs through the skin. After the therapeutic drugs are applied to the skin, they diffuse into each layer of the skin by passing through the stratum corneum of the skin. , absorbed by the capillaries in the skin tissue into the systemic circulation. Ethosomes are one of the most concerned novel carriers for transdermal drug delivery systems. [0003] Ethosomes, or alcohol-containing liposomes, are a new type of transdermal drug delivery carrier with a vesicle structure first invented by the world-renowned Israeli scientist Professor Touitou. The main difference between alcohol liposomes and ordinary liposomes is that ethanol is contained in liposome vesicles, and phospholipids are the main chemical components in the bilay...

AI Technical Summary

Problems solved by technology

Existing percutaneous local anesthetic preparations such as: compound lidocaine cream, or related preparations of other local anesthetics, such as gel, tincture, cream, transdermal patch, etc., due to obvious side effects, slow onset, and penetration effect Safe and effective local anesthesia cannot be achieved due to unsatisfactory reasons

At present, there are two main methods of increasing the transdermal permeability of drugs, physical or chemical methods, but there are certain limitations and deficiencies in both.

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