A kind of buflodil hydrochloride compound and pharmaceutical composition thereof

A technology of buflomedil hydrochloride and its compound, which is applied in the field of medicine, can solve problems affecting product stability, effectiveness and safety, internal quality of drug effect, decreased fluidity, and unsatisfactory effect, etc., to achieve excellent drug release behavior, Effect of reducing solubility and improving hygroscopicity
CN105924411BActive Publication Date: 2018-12-11王珍 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
王珍
Publication Date
2018-12-11

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a bullomedil hydrochloride compound and a pharmaceutical composition thereof. The structural formula of the bullomedil hydrochloride compound is as follow (see the formula in the description). An X-ray powder diffraction spectrogram obtained by measuring the bullomedil hydrochloride compound with Cu-Kalpha rays is shown as the figure one. The provided bullomedil hydrochloride compound reduces solubility of bullomedil hydrochloride bulk drugs in water to a certain degree, is in a new crystal form and has improved hygroscopicity. Meanwhile, it is indicated through tests that a sustained release tablet prepared from the bullomedil hydrochloride compound shows better drug release behaviors on the condition of the same prescription and the same preparing method.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a buflomedil hydrochloride compound and a pharmaceutical composition thereof. Background technique

[0002] Buflomedil hydrochloride, chemical name: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride.

[0003] Molecular formula: C 17 h 25 NO 4 .HCl

[0004] Molecular weight: 343.85

[0005] Pharmacological type: This product is an α-adrenergic receptor inhibitor, and has weak non-specific calcium ion antagonism. Improves microcirculatory blood flow in the brain and extremities by inhibiting the spasm of the anterior capillary sphincter. This product also has the functions of inhibiting platelet aggregation and improving red blood cell deformability.

[0006] Pharmacokinetics: After intravenous infusion, buflomedil hydrochloride is widely distributed in tissues and body fluids, metabolized by the liver, and the elimination half-life is abou...

Claims

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