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The preparation method and medical application of the anti-tumor extract of silkworm Bombyx mori and its composition

A white silkworm, extract technology, applied in the field of medicine, can solve the problem of unclear anti-tumor active ingredients

Active Publication Date: 2019-08-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, its anti-tumor active ingredients have been unclear

Method used

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  • The preparation method and medical application of the anti-tumor extract of silkworm Bombyx mori and its composition
  • The preparation method and medical application of the anti-tumor extract of silkworm Bombyx mori and its composition
  • The preparation method and medical application of the anti-tumor extract of silkworm Bombyx mori and its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Get 20g of the Uyghur medicine Bombyx basalis through organic solvent ultrasonic extraction. 2 ) column separation, the silica gel (silica) column (2.0cm inner diameter small column) after loading the sample, first eluted with chloroform:methanol mixed solvent (chloroform:methanol, 100:1, volume ratio) 10 times column volume, then Use chloroform-methanol mixed solvent (chloroform:methanol, 100:14, volume ratio) to elute 15 times column volume, chloroform:methanol 100:14 eluate is recovered organic solvent, vacuum-dried, namely this C6 inhibitory active extract , the yield was 0.6%.

Embodiment 2

[0095] Get 20g of the Uyghur medicine Bombyx basalis through organic solvent ultrasonic extraction; 2 ) column separation, the silica gel (silica) column (2.0cm inner diameter small column) after loading the sample, first eluted with chloroform:methanol mixed solvent (chloroform:methanol, 100:1, volume ratio) 10 times column volume, then Use chloroform-methanol mixed solvent (chloroform:methanol, 100:14, volume ratio) to elute 15 times column volume, chloroform:methanol 100:14 eluate is recovered organic solvent, vacuum-dried, namely this C6 inhibitory active extract , the yield was 0.51%.

Embodiment 3

[0097] Get 20g of the Uyghur medicine Bombyx basalis through organic solvent ultrasonic extraction. 2 ) column separation, the silica gel (silica) column (2.0cm inner diameter small column) after loading the sample, first eluted with chloroform:methanol mixed solvent (chloroform:methanol, 100:1, volume ratio) 10 times column volume, then Use chloroform-methanol mixed solvent (chloroform:methanol, 100:14, volume ratio) to elute 15 times column volume, chloroform:methanol 100:14 eluate is recovered organic solvent, freeze-dried, namely this C6 inhibitory active extract , the yield was 0.44%.

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Abstract

The invention belongs to the technical field of medicines, and concretely relates to a preparation method of a Uygur medicine silkworm larva antitumor effective position and a composition thereof, and an application of the effective position in the preparation of medicines for preventing and treating liver cancer, lung cancer, stomach cancer, intestinal cancer, pancreas cancer, breast cancer, brain glioma and other malignant tumors. The preparation method of the above extract comprises the following steps: carrying out ultrasonic extraction on the Uygur medicine silkworm larva with an organic solvent, airing obtained medicinal residues, extracting the aired medicinal residues with water, concentrating above obtained extract liquids, carrying out silica gel separation, eluting a sample introduced SiO2 column with a chloroform and methanol mixed solvent with the volume ratio of chloroform to methanol of 100:0-100:1, eluting the column with a chloroform and methanol mixed solvent with the volume ratio of chloroform to methanol of 100:3-100:14, eluting the column with the chloroform and methanol mixed solvent with the volume ratio of chloroform to methanol of 100:3-100:14, recovering the organic solvent from the obtained eluate, and drying the organic solvent recovered eluate to obtain the effective extract.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a Uighur drug Bombyx mori anti-tumor effective extract and its composition and its therapeutic effect on liver cancer, lung cancer, gastric cancer, colon cancer, pancreatic cancer, breast cancer, and brain glioma. Prevention and treatment of malignant tumors and other purposes. Background technique [0002] This product is Bombyx Batryticatus, also known as Bombyx Batryticatus ("Qian Jin Fang") and Tian Chong ("Compilation of Medicinal Materials"), which is infected (or artificially inoculated) ) Pathogen Beauve Habassiarta (Beauve Habassiarta) induces Beauveria bassiana and dead dry worms, as a Chinese herbal medicine first recorded in "Shen Nong's Materia Medica". Baijiangxiang is mostly produced in spring and autumn, and it is slightly cylindrical, mostly curved and shrunken. The surface is covered with white powder-like aerial hyphae and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P35/00
Inventor 王金辉黄健孙富周
Owner SHENYANG PHARMA UNIVERSITY