Experiment analysis method for blood glucose reducing efficacy of Shenlian decoction rapidly disintegrating tablets for reducing blood glucose

A technology of experimental analysis and fast disintegrating tablets, applied in the field of traditional Chinese medicine research, can solve the problem of type 2 diabetes that needs to be studied, and achieve the effect of lowering blood sugar levels

Inactive Publication Date: 2016-10-12
CHANGCHUN UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, the targets and mechanism of action of total ginseng saponins and total alkaloids of Coptis chinensis in the treatment of type 2 diabetes are still to be studied

Method used

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  • Experiment analysis method for blood glucose reducing efficacy of Shenlian decoction rapidly disintegrating tablets for reducing blood glucose
  • Experiment analysis method for blood glucose reducing efficacy of Shenlian decoction rapidly disintegrating tablets for reducing blood glucose
  • Experiment analysis method for blood glucose reducing efficacy of Shenlian decoction rapidly disintegrating tablets for reducing blood glucose

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0054] The experimental analysis method for the hypoglycemic efficacy of Shenlianyin Jiangtang Sudisintegrating Tablets, such as figure 1 shown, including the following steps,

[0055] Step 1. Select the experimental group

[0056] Select 250 C57 mice, take 20 of them to form the CON control group, and the remaining 230 were prepared as the diabetic nephropathy model group; the CON group was fed with normal diet, and the model group was fed with high-fat diet. After four weeks of feeding, 30 mg of C57 mice were injected intraperitoneally Streptozotocin STZ per kg twice, one week later, the CON group was given citrate buffer with the same volume as STZ, four weeks after the injection of STZ, fasting blood glucose was measured, fasting blood glucose > 7.8mmol / L was the judgment of diabetes standard;

[0057] Take 10 mice in the CON group to give the vehicle for 8 weeks, take 20 mice in the model group to give the vehicle for 8 weeks, and take 20 mice in the model group to give...

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Abstract

The invention provides an experiment analysis method for blood glucose reducing efficacy of Shenlian decoction rapidly disintegrating tablets for reducing blood glucose and belongs to the technical field of traditional Chinese medicine research. The method comprises the following steps of step one, selection of experiment grouping; step two, detection of physiological indicators, including detection of mice fasting blood-glucose, total cholesterol and triglyceride, detection of glucose tolerance, detection of urine volume, urine protein and urinary albumin, detection of serum creatinine and serum urea nitrogen, detection of serum sodium and serum potassium, detection of urine sodium and urine potassium and detection of weight and kidney indexes; step three, statistics of pathology; step four, analysis of statistical results; according to the experiment analysis method, an effective constituent ginseng total saponin and coptis total alkaloid compound (RH for short) of the Shenlian decoction rapidly disintegrating tablets for reducing blood glucose can effectively reduce the blood glucose level of a diabetic patient and has a certain therapeutic effects for early diabetic nephropathy.

Description

technical field [0001] The invention belongs to the technical field of Chinese materia medica research, and in particular relates to a method for analyzing the therapeutic effect of Shenlianyin Jiangtang Sudisintegrating Tablets made of total ginsenosides and total alkaloids of Coptis chinensis on diabetes and diabetic nephropathy. Background technique [0002] Diabetes, which is called "Xiaoke" in traditional Chinese medicine, is a disease of the secretion system caused by metabolic disorders. Studies have shown that there were 382 million diabetics worldwide in 2013, and it is predicted that this number will rise to 592 million by 2035. Diabetes is divided into Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM). According to the latest statistics from WHO, the death rate of diabetes has risen to the third place after cancer and cardiovascular and cerebrovascular diseases. Because of its complex pathogenesis, so far, the clinical treatment of diabetes is ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50A61K36/718A61K9/20A61P3/10
CPCG01N33/50A61K9/20A61K36/258A61K36/718A61K2300/00
Inventor 张辉孙佳明魏忠宝吴楠张美双任伯颖唐珊杜延佳刘冬刘侗
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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