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Application of DADS (diallyl disulfide) to preparation of spermatogenic cell radiation injury resistant medicine

A technology of diallyl disulfide and drugs, which is applied in the field of biomedicine, can solve the problems that the radiation protection effect of testicular tissue has not been reported in literature, etc., and achieve good application prospects and medical significance, as well as significant preventive and therapeutic effects

Inactive Publication Date: 2016-11-09
ZHAOQING MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, there is no literature report on the radiation protection effect of DADS on testicular tissue

Method used

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  • Application of DADS (diallyl disulfide) to preparation of spermatogenic cell radiation injury resistant medicine
  • Application of DADS (diallyl disulfide) to preparation of spermatogenic cell radiation injury resistant medicine

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Experimental program
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Embodiment 1

[0026] 1. Materials and methods

[0027] 1.1 Experimental materials

[0028] DADS was purchased from Sigma Company.

[0029] Malondialdehyde (MDA) kits, total carbonyl kits, and 8-hydroxydeoxyguanosine (8-OHdG) kits were purchased from Beyotime Institute of Biotechnology.

[0030] BCA kit was purchased from Thermo Company. The rest are analytically pure.

[0031] 1.2 Experimental animals

[0032] Healthy male Kunming mice with a standard weight of (18-22) g were provided by the Guangdong Experimental Animal Center (permit number: SCXK (Guangdong) 2013-0002).

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Abstract

The invention discloses application of DADS (diallyl disulfide) to preparation of medicine for preventing and / or treating radiation injury on testicular tissues. Concretely, the condition that the DADS can lower the influence of radiation on the sperm motility of a mouse is determined; the injury response of radiation on sperms can be effectively resisted; partial protein in testicular tissue cells can be protected from being injured by radiation; the injury response of radiation on testicular tissue cell lipid can be effectively resisted; the injury response of radiation on testicular tissue cell nucleic acid can be effectively reduced; the obvious significance for preventing and treating radiation on the reproductive system injury is realized. In addition, the DADS has low toxicity and is easy to obtain; the cost is low; the DADS is a lipid-solubility molecule and easily penetrates through physiological barriers such as a blood brain barrier, a blood-testis barrier and a blood-air barrier; the effect can be achieved in a physiological position in which water-soluble medicine is difficult to reach; good application prospects are realized.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of diallyl disulfide in the preparation of anti-radiation damage medicine for germ cells. Background technique [0002] With the development of aerospace technology, nuclear industry technology and nuclear medicine, the risk of exposure to ionizing radiation has gradually increased for relevant professionals, tumor patients and the general public. Among the various damage reactions caused by ionizing radiation to the body, bone marrow suppression, lung damage, digestive system damage, immune system damage and reproductive system damage are the most serious. Therefore, research on radiation protection against these ionizing radiation injuries is becoming more and more important. In addition to affecting the irradiated body, ionizing radiation can also affect the life activities of its offspring through the teratogenic effect on germ cells. Th...

Claims

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Application Information

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IPC IPC(8): A61K31/10A61P15/08A61P39/00
CPCA61K31/10
Inventor 许帅邹锦慧廖伟雄李捷
Owner ZHAOQING MEDICAL COLLEGE
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