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Semi-interpenetrating network nano hybrid hydrogel and preparation method and application thereof

A semi-interpenetrating network and hydrogel technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low phase transition temperature, poor targeting of drug release carriers, etc. problems, achieve good swelling balance, avoid gastric acid and enzyme damage, and improve utilization

Inactive Publication Date: 2016-11-09
SHAANXI NORMAL UNIV
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Problems solved by technology

[0003] The object of the present invention is to provide a kind of temperature and pH double sensitive poly N-isopropylacrylamide / carboxymethyl chitosan / carbon nanotube (PNIPAM / CMCS / MWCNTs) semi-interpenetrating network nano-hybrid hydrogel and Its preparation method and application are aimed at solving the problems of relatively low volume phase transition temperature (VPTT) and poor targeting as a drug release carrier based on poly-N-isopropylacrylamide (PNIPAM) homopolymer hydrogel

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  • Semi-interpenetrating network nano hybrid hydrogel and preparation method and application thereof
  • Semi-interpenetrating network nano hybrid hydrogel and preparation method and application thereof

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[0062] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0063] In the present invention, chitosan is modified to prepare water-soluble carboxymethyl chitosan, and then cross-linked with purified N-isopropylacrylamide and treated carbon nanotubes to prepare a series of different nanotubes. At the same time, the law of water absorption and swelling of the hydrogel over time was investigated; in order to prepare a hydrogel with good performance that is temperature-sensitive and pH-responsive and suitable for drug carriers.

[0064] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0065] The poly N...

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Abstract

The invention discloses a semi-interpenetrating network nano hybrid hydrogel and a preparation method and an application thereof. Firstly, chitosan is modified to prepare water soluble carboxymethyl chitosan (CMCS); then N-isopropylacrylamide (NIPAM), CMCS and (carboxyl functionalized) carbon nanotubes are subjected to in-situ free radical crosslinking polymerization reaction, and the semi-interpenetrating network nano hybrid hydrogel with different composition ratios of NIPAM, CMCS and the nanotubes is obtained. The prepared novel nano hybrid hydrogel has relatively high swelling rate, appropriate volume phase transition temperature and pH phase transition point, and high drug loading amount and continuous controllable drug release behavior. The hydrogel pharmaceutical preparation can be used as a promising hydrophilic oral drug carrier, is used for targeted release of oral vaccines, polypeptides, proteins and anticancer drugs, has low toxicity, and can be used for long-term treatment of colon cancer and the like.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials and their composite materials, and in particular relates to a semi-interpenetrating network nano-hybrid hydrogel and its preparation method and application. Background technique [0002]Today, due to environmental issues and unhealthy diet, more and more people are affected by various diseases, especially cancer. It is not only difficult to treat cancer, but also the patients have to bear the great pain caused by the less absorption of treatment means and treatment drugs in the process of treatment. Therefore, how to make therapeutic drugs work better, especially the use of drug carriers for drug delivery, has attracted more and more attention from various scholars. There are many types that can be used as drug carriers, including hydrogels, liposomes, and magnetic polymer microspheres. In the past 50 years, hydrogel has received extensive attention due to its special proper...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08J3/075C08L51/02C08F251/00C08F220/54C08F222/38C08K9/04C08K7/24C08B37/08A61L27/20A61L27/52A61L27/18A61K9/06A61K47/36A61K47/34A61K47/04A61K31/704
CPCA61K9/06A61K31/704A61K47/02A61K47/34A61K47/36A61L27/18A61L27/20A61L27/52C08B37/003C08F251/00C08J3/075C08J9/28C08J2351/02C08K7/24C08K9/04C08K2201/011C08L51/02C08L2205/04C08F220/54
Inventor 罗延龄张雪银付婧玉徐峰
Owner SHAANXI NORMAL UNIV
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