Extraction separation method of synthetic acid dyes illegally added into traditional Chinese medicinal materials and rapid detection method

A separation method and illegal addition technology, applied in the field of food and drug detection and analysis, can solve the problems of long separation time, insufficient recovery rate of detection and analysis, low efficiency, etc., achieve broad application prospects, improve extraction efficiency, and improve the effect of detection ability

Active Publication Date: 2016-12-07
SHANGHAI INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to overcome the various defects in the above-mentioned prior art, especially for technical problems such as long extraction and separation time-consuming and low efficiency of the existing method, detection and analysis recovery rate is not high enough, etc.

Method used

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  • Extraction separation method of synthetic acid dyes illegally added into traditional Chinese medicinal materials and rapid detection method
  • Extraction separation method of synthetic acid dyes illegally added into traditional Chinese medicinal materials and rapid detection method
  • Extraction separation method of synthetic acid dyes illegally added into traditional Chinese medicinal materials and rapid detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Extraction, separation and detection of synthetic acidic pigments illegally added to Coptis chinensis powder produced by a factory A:

[0055] In this example 1, using as image 3 The extraction and separation device shown includes: extractor upper cover 1, extractor lower cover 2, WAX solid phase extraction column 3, solid phase extraction cylinder 4, SPE adapter 5, double male Luer connector 6, Luercock Valve 7 and extraction hose 8; wherein, the extractor upper cover 1, the extractor lower cover 2, the SPE adapter 5, the double male Luer connector 6 and the Luercock valve 7 All materials are polypropylene; the extraction hose 8 is made of silica gel, with an inner diameter of 4mm and an outer diameter of 6mm.

[0056] The structure of the extractor loam cake 1 is as figure 1 As shown, the structure of the extractor lower cover 2 is as follows figure 2 As shown; wherein, the center of the extractor upper cover 1 is provided with a small through hole, and the cente...

Embodiment 2

[0079] Extraction, separation and detection of synthetic acidic pigments illegally added to Coptis chinensis powder produced by a factory B:

[0080] In this example 2, using as image 3 The extraction and separation device shown includes: extractor upper cover 1, extractor lower cover 2, WAX solid phase extraction column 3, solid phase extraction cylinder 4, SPE adapter 5, double male Luer connector 6, Luercock Valve 7 and extraction hose 8; wherein, the extractor upper cover 1, the extractor lower cover 2, the SPE adapter 5, the double male Luer connector 6 and the Luercock valve 7 All materials are polypropylene; the extraction hose 8 is made of silica gel, with an inner diameter of 4mm and an outer diameter of 6mm.

[0081] The structure of the extractor loam cake 1 is as figure 1 As shown, the structure of the extractor lower cover 2 is as follows figure 2 As shown; wherein, the center of the extractor upper cover 1 is provided with a small through hole, and the cente...

Embodiment 3

[0094] Extraction, separation and detection of synthetic acidic pigments illegally added to Danshen decoction pieces powder produced by a factory A:

[0095] In this example 3, using as image 3 The extraction and separation device shown includes: extractor upper cover 1, extractor lower cover 2, WAX solid phase extraction column 3, solid phase extraction cylinder 4, SPE adapter 5, double male Luer connector 6, Luercock Valve 7 and extraction hose 8; wherein, the extractor upper cover 1, the extractor lower cover 2, the SPE adapter 5, the double male Luer connector 6 and the Luercock valve 7 All materials are polypropylene; the extraction hose 8 is made of silica gel, with an inner diameter of 4mm and an outer diameter of 5mm.

[0096] The structure of the extractor loam cake 1 is as figure 1 As shown, the structure of the extractor lower cover 2 is as follows figure 2 As shown; wherein, the center of the extractor upper cover 1 is provided with a small through hole, and t...

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Abstract

The invention provides an extraction separation method of synthetic acid dyes illegally added into traditional Chinese medicinal materials. An extraction separation device comprises an extractor upper cover (1), an extractor lower cover (2), a WAX solid-phase extraction column (3), a solid-phase extraction tank (4), a SPE (solid phase extraction) adapter (5), a double-male Luer connecter (6), a Ruhr corker valve (7), an extraction hose (8), a stainless steel mesh (12) and a stainless steel filter disc (13). The extraction separation method can efficiently extract and separate the synthesis acid dyes in shorter consuming time. The invention further provides a rapid detection method of synthesis acid dyes illegally added into traditional Chinese medicinal materials. By the aid of the extraction separation method, synthesis acid dyes are detected by an HPLC (high-performance liquid chromatography) or an HPLC-MS (high-performance liquid chromatography-mass spectrum) system, so that the recovery rate of various synthesis acid dyes is remarkably increased, extraction efficiency is greatly improved, and the detection capability of the rapid detection method is improved, so that the rapid detection method has wide application prospects and good market potential.

Description

technical field [0001] The invention relates to the field of food and drug detection and analysis, in particular to an extraction and separation method for illegally added synthetic acidic pigments in Chinese medicinal materials, and also to a rapid detection method for the illegally added synthetic acidic pigments. Background technique [0002] Because synthetic pigments have varying degrees of allergenicity and even carcinogenicity, according to the relevant regulations on the supervision of Chinese herbal medicines, no artificial colorants (synthetic pigments) are allowed to be added to Chinese herbal medicines. However, the phenomenon of illegal dyeing of Chinese herbal medicines on the market is very serious. Criminals dye medicinal materials to achieve illegal purposes such as covering up adulteration, substituting inferior ones for good ones, and reusing extracted medicinal materials as medicines. Among them, the common dyeing Chinese medicines on the market include: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34G01N30/06
CPCG01N1/34G01N30/06
Inventor 胡青季申郑希望孙健张甦苗水于泓冯睿崔亚君毛秀红夏晶李丽敏陆继伟王少敏毛丹杨新华陈铭曹帅陈虹周恒兰岚程益清
Owner SHANGHAI INST FOR FOOD & DRUG CONTROL
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