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Application of beta-aescine in preparation of medicines for preventing or treating decompression sickness

A escin and decompression sickness technology, applied in the field of medicine, can solve the problem that there is no preventive effect of β-escin on decompression sickness, and achieve the effect of high safety and wide treatment window

Inactive Publication Date: 2016-12-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, the medicinal reports about β-escin mainly relate to aspects such as chronic venous insufficiency, hemorrhoids, edema (Sirtori C R. Aescin: pharmacology, pharmacokinetics and therapeutic profile. 193.; Hou Minghua. Clinical application and adverse reaction analysis of sodium aescinate. Medicine, 2015(8):247-247.; Zhou Hua, Yang Yulan, Li Jiayi. Overview of clinical application of β-escin sodium. Journal of Practical Chinese Medicine ,2013(10):881-883.), but there is no relevant literature report on the research on the preventive effect of β-escin on decompression sickness

Method used

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  • Application of beta-aescine in preparation of medicines for preventing or treating decompression sickness
  • Application of beta-aescine in preparation of medicines for preventing or treating decompression sickness
  • Application of beta-aescine in preparation of medicines for preventing or treating decompression sickness

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Embodiment

[0025] To prepare the β-escin solution, the process is as follows: Weigh an appropriate amount of β-escin (purchased from Sigma-Aldrich) and dissolve it in physiological saline to make 1.8 mg / ml.

[0026] The administration group was given β-escin solution (1.8 mg / kg / day, continuous administration for 7 days).

[0027] The saline control group was given the same dose of normal saline in the same way for the same time.

[0028] After the administration, the rat model of decompression sickness is prepared. The process is as follows: After the administration, the weight of the rat is controlled to be 300-310g, and the rat is placed in a pressurized chamber at a speed of slowing first and then fast within 5 minutes Pressurize to 7ATA, maintain for 90 minutes, and reduce to normal pressure at a constant rate of 2ATA / min. After exiting the cabin, transfer to the electric running cage designed by the applicant (application number: CN200920077520.7, publication number CN201557446U, inventio...

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Abstract

The invention relates to the technical field of biomedicines, and provides an application of beta-aescine in the preparation of medicines for preventing or treating decompression sickness. In vivo experiments show that beta-aescine administration effectively reduces the incidence and the mortality of the decompression sickness of rats and prolongs the incubation period of decompression sickness and the survival time, so the beta-aescine can effectively prevent the decompression sickness of the rats.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to the application of β-escin in the preparation of drugs for preventing or treating decompression sickness. Background technique [0002] When divers enter the water, they must breathe high-pressure gas at the same pressure as the surrounding water. A large amount of physiologically inert gas (such as nitrogen, helium, etc.) will be dissolved into the body. To ensure that these gases are safely discharged from the body, the diver’s ascent and decompression Certain rules must be followed. A slight impropriety may form bubbles in the body, leading to decompression sickness. In addition, in space operations (space out of space activities or fighter jets high-altitude pull-up), a large reduction in ambient air pressure can also cause decompression sickness. The condition of decompression sickness is complex, progresses rapidly, seriously endangers the life and health of divers, and usuall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P39/00
CPCA61K31/704
Inventor 徐伟刚张坤蒋忠新宁小伟衣洪杰
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY