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Application of r,s-1,3-butanediol acetoacetate diester in preparation of medicine for preventing or treating decompression sickness

A technology for butanediol acetoacetate diester and decompression sickness, which is applied in the field of medicine and achieves the effects of good application prospect, prolonged incubation period and improved diving operation efficiency.

Active Publication Date: 2020-09-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] There is no relevant literature report on the effect of R,S-1,3-butanediol acetoacetate diester on the prevention or treatment of decompression sickness

Method used

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  • Application of r,s-1,3-butanediol acetoacetate diester in preparation of medicine for preventing or treating decompression sickness
  • Application of r,s-1,3-butanediol acetoacetate diester in preparation of medicine for preventing or treating decompression sickness
  • Application of r,s-1,3-butanediol acetoacetate diester in preparation of medicine for preventing or treating decompression sickness

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Embodiment 1

[0031] Animal fasting treatment: Before establishing the decompression sickness model, the weight of the rats was controlled at 300-310g. The rats in the treatment group and the saline control group were fasted 18 hours in advance to empty the intestinal contents, and they were free to drink water during this period.

[0032] Rats in the treatment group were given R,S-1,3-butanediol acetoacetate diester (5g / kg) by intragastric administration once.

[0033] Rats in the saline control group were given the same dose of normal saline in the same manner.

[0034] One hour after the end of the administration, the rat model of decompression sickness was prepared. The process was as follows: One hour after the end of the administration, the rats were placed in the pressurized chamber, and the pressure was first increased to 4ATA at a rate of 1ATA / min, and then 1.5ATA / min. Pressurize to 7ATA at a speed of 1 / min, maintain for 90 minutes, and then reduce to normal pressure at a constant ...

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Abstract

The invention discloses application of R,S-1,3-butanediol acetoacetate diester in preparing medicines for preventing or treating decompression sickness. The medicines for preventing or treating decompression sickness take the R,S-1,3-butanediol acetoacetate diester as the only active ingredient or contain a medicinal composition of the R,S-1,3-butanediol acetoacetate diester. According to the application of the R,S-1,3-butanediol acetoacetate diester in preparing the medicines for preventing or treating decompression sickness, provided by the invention, shown by experimental results in animalbodies, administration of the R,S-1,3-butanediol acetoacetate diester reduces the incidence rate of decompression sickness in rat models from 73.1% to 34.6%, and the latent period of decompression sickness is obviously prolonged, thereby showing that the R,S-1,3-butanediol acetoacetate diester can effectively prevent or treat decompression sickness in rats. Therefore, the R,S-1,3-butanediol acetoacetate diester has good application prospects in prevention or treatment of decompression sickness.

Description

[0001] technology field [0002] The invention relates to the technical field of medicine, in particular to the application of R,S-1,3-butanediol acetoacetate diester in the preparation of medicines for preventing or treating decompression sickness. Background technique [0003] Entering the underwater high-pressure environment, divers need to breathe gas at the same pressure as the environment. As the partial pressure increases, the physiologically inert gas in the breathing gas (referring to the gas that is not consumed by human metabolism, mainly nitrogen in air diving, and usually helium in deep diving) is more dissolved in the body. When returning to the water surface after diving, if the ascent speed is too fast, the saturation of the inert gas dissolved in the body will increase rapidly, and if the supersaturation limit is exceeded, bubbles will be precipitated and form, leading to decompression sickness. This disease can also be caused by a sharp drop in ambient air p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P43/00A61P39/06A61P29/00A61P7/04A61P17/04A61P17/00A61P9/00A61P25/00
CPCA61K31/122
Inventor 徐伟刚张坤王蒙蒙彭智慧衣洪杰俞世冲张大志
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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