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A centrifugal microfluidic chip and a method for continuously synthesizing janus particles

A microfluidic chip and centrifugal technology, applied in the field of microfluidics, to achieve the effect of improving the synthesis yield

Active Publication Date: 2018-10-23
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems existing in the production rate of Janus particles synthesized by existing microfluidic methods, the present invention provides a centrifugal microfluidic chip and a method for continuously synthesizing Janus particles

Method used

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  • A centrifugal microfluidic chip and a method for continuously synthesizing janus particles
  • A centrifugal microfluidic chip and a method for continuously synthesizing janus particles
  • A centrifugal microfluidic chip and a method for continuously synthesizing janus particles

Examples

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Embodiment 1

[0056] The centrifugal microfluidic chip of the present invention, such as figure 1 As shown, it is composed of an upper substrate a, an intermediate substrate b and a lower substrate c; the upper substrate, the intermediate substrate and the lower substrate are concentric circles and are equal in size;

[0057] For the upper substrate, an upper central circular hole is arranged at the center of the upper substrate; an annular liquid pool 1 is arranged on the upper substrate, and the annular liquid pool 1 is concentric with the upper substrate a, and the annular liquid pool 1 is concentric with the upper substrate a. The pool 1 penetrates the upper substrate a, and the outer side of the annular liquid pool 1 is provided with several upper dispersed circular channels, and several upper dispersed circular channels are evenly distributed on the upper substrate along the circumferential direction. The annular liquid pools are connected through a first-level straight channel 2, and...

Embodiment 2

[0087] The structure and material of the centrifugal microfluidic chip used in this example are the same as in Example 1, but the size is different:

[0088] In this implementation, the diameter of the annular liquid pool is 14mm, and the diameter of the upper substrate is 70mm, then S:D=14:70; and the difference between the inner diameter and outer diameter of the upper annular liquid pool is 1mm;

[0089] In this implementation, the upper substrate is provided with 36 upper dispersed circular holes, and the diameter of the upper dispersed circular hole is 0.9 mm; the center distance between the upper dispersed circular channel and the upper substrate is 28.45 mm;

[0090] In this implementation, the width of the first-level straight channel=the width of the second-level straight channel=the width of the third-level straight channel, both of which are 200 μm;

[0091] In this implementation, the distance between the connecting point of the secondary straight channel and the t...

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Abstract

A centrifugal microfluidic chip and a method for continuously synthesizing Janus particles; the chip is composed of an upper substrate, a middle substrate and a lower substrate; the upper substrate is provided with an upper central circular hole, an annular liquid pool, and several upper layers The dispersed circular channels are connected with several first-level straight channels; the middle layer substrate is provided with a central circular hole in the middle layer; the lower substrate is provided with a central liquid pool, a lower dispersed circular channel, several second-level straight channels and several third-level straight channels. Straight channel; Method: 1) Fix the centrifugal microfluidic chip on the suction cup of the glue homogenizer; 2) Inject different test solutions into the central liquid pool and the annular liquid tank; open the glue homogenizer and rotate and centrifuge to form a biphasic phase at the outlet of the channel liquid droplets; 3) biphasic liquid droplets are thrown into an external annular liquid pool to form Janus particles; the method of the invention ensures the continuous introduction of test liquids and realizes the continuous synthesis of biphasic particles; the array synthesis channel, high-speed rotation drive liquid and continuous Synthesis, improve the synthesis rate of Janus particles.

Description

technical field [0001] The invention belongs to the field of microfluidic technology, in particular to a centrifugal microfluidic chip and a method for continuously synthesizing Janus particles. Background technique [0002] Janus is a god with two faces in ancient Roman mythology. In 1991, De Gennes used Janus to visualize asymmetric particles for the first time in his Nobel acceptance speech. Because different properties can be exhibited on the same particle, this Janus particle with asymmetric double-sided structure shows better performance than particles with a single property in some application fields, such as emulsion stability, optics, biosensing , drug delivery, and electronics have potential applications. [0003] The synthesis method based on microfluidic technology has high mass and heat transfer efficiency, easy and accurate control of reaction conditions, fast mixing speed, and low reagent consumption. The use of microfluidic technology in the synthesis of Ja...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J19/00
CPCB01J19/0093
Inventor 徐章润宋丹孙小婷刘梅杨春光
Owner NORTHEASTERN UNIV LIAONING
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