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56 results about "Centrifugal microfluidics" patented technology
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Bidirectional flow centrifugal microfluidic devices
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms for achieving efficient mixing of one or a plurality of fluids on the surface of the platform when fluid flow is motivated by centripetal force produce by rotation.
Owner:TECAN TRADING AG
Centrifugal micro-fluidic device and method for detecting target in fluid sample
InactiveUS20110124132A1Bioreactor/fermenter combinationsBiological substance pretreatmentsCentrifugal microfluidicsMicro fluidic
Disclosed are a centrifugal micro-fluidic device and an immunosorbent assay method using the same. In particular, a centrifugal micro-fluidic device having a plurality of micro-fluidic structures placed in a disc type platform to simultaneously conduct several immunosorbent assays, as well as an immunosorbent assay method using the same are provided.
Owner:SAMSUNG ELECTRONICS CO LTD
Separate detection system and method of rare cells based on centrifugal micro-fluidic technology
ActiveCN103018224ARealize in-situ automatic detectionAvoid lostPreparing sample for investigationBiological testingLiquid wasteLow speed
The invention discloses a separate detection system and method of rare cells based on a centrifugal micro-fluidic technology. The system comprises a micro-fluidic chip similar to an optical disk, a centrifugal drive module and an optical detection module, wherein the micro-fluidic chip comprises a plurality of groups of micro-channels and micro-cavities arranged in a radiation manner; and the entire chip structure is composed of an elastic micro-column guide rail layer, a deformable film layer, a pipeline / cavity layer, a filtering membrane layer and a liquid waste collecting layer. The method comprises the steps of: firstly, leading a sample solution and immune modified microspheres into a liquid storage cavity through an injection port of the micro-fluidic chip in use, putting the sample solution and the immune modified microspheres on a centrifugal platform of the centrifugal drive module, assembling an elastic micro-column, and rotating at a low speed, so as to achieve fully mixing and reacting of the sample solution and immune modified microsphere liquid in the liquid storage cavity, separating by a high-speed rotary chip, and then dropwise adding a specifically recognized fluorescently-labeled antibody solution in each separate cell collection area, carrying out incubate reaction, adding a buffer solution and centrifuging, and finally identifying and analyzing through the optical detection module.
Owner:SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
Microfluidic chip and analysis system
InactiveCN110029052AConvenient and fast positioningFast and convenientBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringPhase change
The application relates to a microfluidic chip and an analysis system. The microfluidic chip comprises a chip matrix, a sample adding chamber, an air outlet, a sample enrichment and pyrolysis chamber,a first waste liquid chamber, a dilution chamber, a capillary valve, a second waste liquid chamber, a sample adding chamber circulation pipeline, a pyrolysis chamber circulation pipeline, an air circulation pipeline, a sample output pipeline, a reagent distribution pipeline and a plurality of PCR amplification chambers; the sample output pipeline is provided with a phase change valve and besidesthe chip matrix is provided with an encapsulation hole communicating with the phase change valve; and positioning areas are arranged in the chip matrix. The microfluidic chip is suitable for centrifugal microfluidic analysis and can realize a molecular diagnostic function of nucleic acid-free purification, the phase change valve can be conveniently placed in the sample output pipeline through theencapsulation hole to control entering of samples in the sample enrichment and pyrolysis chamber into the dilution chamber under certain conditions, a design of the positioning areas is convenient forconveniently and quickly positioning and fixing the microfluidic chip, the microfluidic chip is applied to a centrifugal microfluidic technology to realize a molecular diagnosis based on PCR amplification, and a whole reaction process is in a closed microfluidic chip structure.
Owner:深圳市刚竹医疗科技有限公司
Full-extraction molecular diagnosis microfluidic chip and microfluidic system
PendingCN110452802ARealize acquisitionRealize analysisBioreactor/fermenter combinationsBiological substance pretreatmentsLiquid wasteDisease
The invention relates to a full-extraction molecular diagnosis microfluidic chip and a microfluidic system. The full-extraction molecular diagnosis microfluidic chip includes a storage cavity, a sample cavity, a first liquid adding cavity, a first buffer cavity, at least one controlled liquid adding cavity, a second liquid adding cavity, a distribution cavity, a first liquid waste cavity, a buffering cavity, a second liquid waste cavity, at least one measuring cavity and at least one PCR amplification cavity. The portions, near the rotating center of a target, of the controlled liquid adding cavities are communicated with the second liquid adding cavity through air pipelines, the air pipelines are internally provided with phase change valves, and the controlled liquid adding cavities are communicated with the distribution cavity through liquid adding pipelines. Sample splitting, nucleic acid purification, equal distribution of reagents, amplification of nucleic acids in the chambers under restrictions of specific primers and other processes are all integrated in the centrifugal microfluidic chip, subsequent analysis work such as fluorescence signal collection and analysis can be achieved, a single-sample multi-index diagnosis mode is achieved, and it is possible to screen multiple pathogens of diseases through molecular diagnosis.
Owner:深圳市刚竹医疗科技有限公司
Centrifugal microfluidic platform
InactiveUS20140134631A1Avoid flowEasy to controlBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringCentrifugal microfluidics
A centrifugal microfluidic device is provided having a microfluidic circuit, a fluid reservoir for providing fluid in the microfluidic circuit, a hydrodynamic resistance element in fluid communication with the reservoir for controlling rate of flow of a fluid out of the reservoir, and a siphoned chamber in fluid communication with the hydrodynamic resistance element and the microfluidic circuit for receiving fluid from the hydrodynamic resistance element and for delaying and metering of the fluid into the microfluidic circuit. The microfluidic device is useful for performing a biological assay. Operation of the device is completely independent on the liquid-solid contact angle and wetting properties of the liquids on the solid material of the platform, and the device does not need a carefully controlled rotation protocol.
Owner:NAT RES COUNCIL OF CANADA
Centrifugal microfluidic device having sample distribution structure and centrifugal microfluidic system including the centrifugal microfluidic device
ActiveUS8048387B2Distribute quicklyEasy constructionSpecific gravity using centrifugal effectsMaterial analysis by optical meansInlet channelEngineering
Owner:PRECISIONBIOSENSOR INC
Centrifugal microfluidic device having sample distribution structure and centrifugal microfluidic system including the centrifugal microfluidic device
ActiveUS20080269077A1Distribute quicklyEasy constructionSpecific gravity using centrifugal effectsMaterial analysis by optical meansInlet channelEngineering
Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal microfluidic device includes: a rotatable platform; a sample chamber which is disposed in the rotatable platform and houses a fluid sample; a distribution channel connected to an outlet of the sample chamber; a valve which is disposed in the outlet of the sample chamber; a plurality of non-vented reaction chambers which are disposed in the rotatable platform outside of the distribution channel in the radial direction; and a plurality of inlet channels connecting the distribution channel with the reaction chambers.
Owner:PRECISIONBIOSENSOR INC
Centrifugal CD micro-fluidic chip for capillary electrophoresis and capillary gel electrophoresis device
InactiveCN104646079AHigh sensitivityLow costMaterial analysis by electric/magnetic meansLaboratory glasswaresGel electrophoresisThroughput
The invention belongs to the fields of medicine analysis and detection, particularly relates to a micro-fluidic chip for capillary electrophoresis. The invention provides a centrifugal micro-fluidic chip for capillary electrophoresis to solve the problems that an existing silicon capillary micro-fluidic chip is relatively high in cost and relatively low in sensitivity. The chip comprises a slide glass and a chip cover, wherein capillary electrophoresis channels are formed in the slide glass, and are distributed along the radial direction of the chip; cooling liquid channels are arranged nearby the capillary electrophoresis channels; the initial end of each capillary electrophoresis channel is communicated with a sample pool and a buffer liquid pool; the tail end of each capillary electrophoresis channel is communicated with a waste liquid pool; a cathode inserting hole is formed in the initial end of each capillary electrophoresis channel; an anode inserting hole is formed in each tail end; a gravity control valve is arranged at the tail end of each capillary electrophoresis channel; and cooling liquid connectors are formed at two ends of the cooling liquid channels. The centrifugal micro-fluidic chip is low in cost, high in sensitivity and high in processing throughput.
Owner:方雪萍 +1
Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection
ActiveUS8303911B2Avoid problemsAdd featureBioreactor/fermenter combinationsHeating or cooling apparatusLysisDownstream processing
A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.
Owner:RGT UNIV OF CALIFORNIA +1
Centrifuging micro-fluidic control chip for free nucleic acid extraction and method for extracting free nucleic acid
ActiveCN110016435AGuaranteed stabilityEfficient separation and extractionBioreactor/fermenter combinationsBiological substance pretreatmentsSiphonBlood plasma
The invention provides a centrifuging micro-fluidic control chip for free nucleic acid extraction and a method for extracting free nucleic acid, and belongs to the technical field of free nucleic acidseparating and extracting devices. The centrifuging micro-fluidic control chip comprises a disc, plasma separating chambers, nucleic acid extraction sample cavities, immiscible phase cavities and eluting cavities, wherein the plasma separating chambers, the nucleic acid extraction sample cavities, the immiscible phase cavities and the eluting cavities are in rotary symmetric distribution; each plasma separating chamber communicates with the corresponding nucleic acid extraction sample cavity through a corresponding passive siphon; and each nucleic acid extraction sample cavity communicates with the corresponding immiscible phase cavity and the corresponding eluting cavity through arch capillary microchannels. According to the centrifuging micro-fluidic control chip disclosed by the invention, a dynamic centrifuging micro-fluidic control method and a static immiscible phase micro-fluidic control method are combined for the first time, and the designed immiscible phase nucleic acid extracting and purifying structure realizes uniform mixing under the premise that the interface stability is not influenced; the plasma separating structure is integrated on the centrifuging micro-fluidiccontrol chip, so that the purpose of extracting and purifying free nucleic acid from 4mL whole blood fully-automatically within 15 minutes can be realized, the centrifuging micro-fluidic control chipis the fastest device for extracting and purifying the free nucleic acid from the whole blood at present, and the centrifuging micro-fluidic control chip is hopefully applied to liquid biopsy of thefree nucleic acid.
Owner:XI AN JIAOTONG UNIV
Centrifugal microfluidic chip and nucleic acid analysis system
PendingCN109735431AReduce the burden onReduce pollutionBioreactor/fermenter combinationsBiological substance pretreatmentsBiologyDiagnosis laboratory
The invention relates to a centrifugal microfluidic chip and a nucleic acid analysis system, wherein the centrifugal microfluidic chip comprises a chip substrate, a sample adding cavity, an air outlet, a sample enrichment cracking cavity, a first waste liquid cavity, a first capillary valve, a dilution cavity, a second capillary valve, a second waste liquid cavity and a plurality of PCR amplification cavities. According to the centrifugal microfluidic chip and the nucleic acid analysis system, through the ingeniously designed cavity structure, the PCR amplification technology can be applied tothe centrifugal microfluidic technology to achieve the molecular diagnosis based on the PCR amplification, and through the sequential control of the liquid in the sample adding cavity, the sample enrichment cracking cavity, the dilution cavity and the PCR amplification cavity, the PCR amplification is achieved in the PCR amplification cavity. The whole reaction process is in a closed microfluidicchip structure, so the burden of operators and the possibility of pollution are reduced, the whole molecular diagnosis process does not depend on a molecular diagnosis laboratory or on professional operators any more, thereby meeting the requirement of quick detection anytime and anywhere, and bringing great help for medical examinations and disease prevention and control.
Owner:深圳市呈晖医疗科技有限公司
Reagent sequential loading device, centrifugal microfluidic device and analysis system
ActiveCN110045102AIngenious designImplement sequential loadingLaboratory glasswaresBiological testingEngineeringProcessing cost
The present application relates to a reagent sequential loading device, a centrifugal microfluidic device and an analysis system. The reagent sequential loading device comprises a liquid discharging pipe, a liquid control chamber, a collecting chamber and at least two loading chambers; the liquid discharging pipe communicates with the liquid control chamber and the collecting chamber, and the liquid discharging pipe is equipped with a resistance increasing structure; the loading chamber is provided with a liquid control pipe and a loading pipe; the collecting chamber is provided with a collecting chamber hole, the liquid control chamber is provided with a liquid injection hole, and the distances between each communicating end and the liquid injection hole are different; and the distance from the rotation center is arranged in an order from small to large: the position where the loading chamber communicates with the liquid control pipe, the loading chamber, and the position where the loading chamber communicates with the loading pipe thereof. The implementation is simple, the design difficulty is reduced and the processing cost is saved; the centrifugal speed can be controlled, so that the time interval of loading different reagents is controlled, and time is reserved for reagent reaction or reagent treatment; and by adjusting different reagents in different loading chambers cansequential loading of any reagent be realized.
Owner:深圳市呈晖医疗科技有限公司
Control valve and centrifugal micro-fluidic chip
PendingCN108786944ACompressiblePromote expansionLaboratory glasswaresFluid controllersEngineeringControl valves
The invention belongs to the technical field of micro-fluidic chips, and discloses a control valve arranged on a micro-fluidic channel (2) of a micro-fluidic chip. The micro-fluidic chip comprises a chip body (1), the control valve comprises a valve cavity (3) and a reversible water absorption mechanism (4), and the reversible water absorption mechanism (4) is arranged inside the valve cavity (3).The invention further discloses a centrifugal micro-fluidic chip comprising a valve body (1), a liquid inlet (7), a reaction cavity (8) and the micro-fluidic channel (2), wherein the centrifugal micro-fluidic chip further comprises a control valve arranged between the liquid inlet (7) and the reaction cavity (8), and the control valve is the control valve disclosed in the invention. According tothe control valve and the centrifugal micro-fluidic chip provided by the invention, the process is simple, complex processing is not needed, step-by-step release of a solution can be realized by changing the centrifugal rotational speed, and the control valve is convenient to use.
Owner:DONGGUAN HEC MEDICAL INTELLIGENT DEVICE R&D CO LTD
Centrifugal micro-fluidic splitter
PendingCN109046477AEasy to detectThe cavity structure has a small capacityLaboratory glasswaresTemperature controlCentrifugal microfluidics
The invention provides a centrifugal micro-fluidic splitter. The centrifugal micro-fluidic splitter comprises a centrifugal driving mechanism, a plurality of connection pieces and a plurality of detection card boxes; the centrifugal driving mechanism is provided with a centrifugal rotary shaft; the first ends of the connection pieces are connected with the centrifugal rotary shaft; the detection card boxes comprise box bodies, box covers, photoelectric sensors and temperature control modules, the box bodies are provided with cavity structures with one ends being open, the photoelectric sensorsand the temperature control modules are all arranged on the side walls of the corresponding cavity structures, micro-fluidic chips are located in the cavity structures of the box bodies, and the photoelectric sensors align the detection cavities of the micro-fluidic chips. The micro-fluidic splitter is characterized in that the capacity of the cavity structures of the box bodies is smaller, the temperature control modules can control the temperature more precisely and are particularly suitable for biochemical reactions which are sensitive to temperature reactions, and accordingly the detection results are more precise. Due to the positions of the photoelectric sensors and the micro-fluidic chips are relative still, accordingly the photoelectric sensors can detect the photoelectric signalsof the detection cavities of the micro-fluidic chips.
Owner:深圳市呈晖医疗科技有限公司
Apparatus and method for testing multi-function and drug response of centrifugal microfluidic-based platelets
ActiveUS9927425B2Make fastShorten the timeTransportation and packagingLaboratory glasswaresMedicineTested time
Owner:KOREA UNIV RES & BUSINESS FOUND
Swivel Mount for Centrifugal Microfluidic Chip
ActiveUS20170173589A1Increase varietyAdding substantial costSupporting apparatusCentrifugesDegrees of freedomEngineering
A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.
Owner:NAT RES COUNCIL OF CANADA
Centrifugal microfluidic device
PendingCN108889353ASimple structureLow costBioreactor/fermenter combinationsBiological substance pretreatmentsSpray nozzleEngineering
The invention discloses a centrifugal microfluidic device. The centrifugal microfluidic device comprises a bottom disc, multiple nozzles and a driving part. Multiple collecting cavities distributed inthe circumferential direction are formed in the bottom disc. The nozzles can be arranged on the bottom disc and distributed in the circumferential direction. An outlet of any nozzle is communicated with the interior of one collecting cavity, the distances between the outlets of the nozzles and the bottom walls of the collecting cavities are larger than zero, and the nozzles are located on the sides, close to the center of the bottom disc, of the collecting cavities. The driving part can drive the bottom disc to rotate. By means of the centrifugal microfluidic device, when the driving part drives the bottom disc to rotate, a sodium alginate solution and cell suspension liquid in the nozzles enter the collecting cavities respectively, then multiple hydrogel carriers can be formed, and the production efficiency of the hydrogel carriers is greatly improved.
Owner:UNIV OF SCI & TECH OF CHINA
Method for detecting small molecules in milk based on centrifugal microfluidics, and special chip thereof
The invention provides a method for detecting small molecules in milk based on centrifugal microfluidics, and a special chip thereof. The whole detection method including pretreatment and test strip detection is completed through a centrifugal microfluidic system, manual operation is replaced by mechanical operation, the detection efficiency is greatly improved, the operation steps are simplified, and sources causing errors are reduced. Experiment steps can be effectively simplified, manual operation is replaced by mechanical operation, errors caused by manual operation are reduced, and the detection precision is improved. In the centrifugal microfluidic system, the microfluidic chip is used in cooperation with double-shaft centrifugal platform, the special structure of the microfluidic chip is matched with a rotating shaft and a centrifugal shaft of a double-shaft centrifugal platform, fluid is directionally driven, meanwhile, effective separation of magnetic beads and liquid can be achieved through the magnet, and in addition, the infrared light source heating function of the double-shaft centrifugal platform enables a liquid to be heated to release small molecules.
Owner:CHINA AGRI UNIV
Liquid reagent storage box for centrifugal fluid control and micro-fluidic chip structure
The invention relates to a liquid reagent storage box and a micro-fluidic chip structure. The storage box comprises a reagent box main body, a reagent box bottom plate and a sealing plug. The reagentbox bottom plate and the reagent box main body are matched with each other and form a storage cavity jointly. The position, away from the rotation center of the storage box, of the storage box is provided with an outlet. The outlet is located in the position, adjacent to the reagent box main body, of the reagent box bottom plate. The storage cavity communicates with the outlet and is used for communicating with the exterior through the outlet. The reagent box bottom plate is further provided with an outflow structure at the outlet. The outflow structure and other structures, adjacent to the outflow structure, of the reagent box bottom plate form a height difference. According to the liquid reagent storage box, on the one hand, through the design of the storage cavity, a liquid reagent needed by centrifugal micro-fluidic control can be stored conveniently effectively; and on the other hand, through the design of the height difference of the outflow structure at the outlet, the completeoutflow of liquid in the centrifugal process can be ensured, reagent waste or shortage is avoided, cost is reduced, and the reaction effect of centrifugal micro-fluidic control is ensured.
Owner:深圳市刚竹医疗科技有限公司
Portable bacterial lysis device based on centrifugal microfluidic technology and using method thereof
InactiveCN110938522AImprove cracking efficiencyIncrease throughputBioreactor/fermenter combinationsBiological substance pretreatmentsBacterial lysisCentrifugal microfluidics
The invention, which belongs to the technical field of bacterial lysis devices, discloses a portable bacterial lysis device based on a centrifugal microfluidic technology and a using method thereof. The device comprises upper and lower circular plates, a disc micro-fluidic chip, and a rotating shaft, wherein the disc micro-fluidic chip and the rotating shaft are parallel to each other between theupper and lower circular plates. The rotating shaft passes through the parts, away from the circle centers, of the circulate plates but is not in contact with the circular plates; and the rotating shaft passes through the circle center of the disc micro-fluidic chip. A plurality of magnets are respectively arranged on the circular plates and are uniformly distributed on each circular plate, wherein the magnets are mutually staggered in a vertical position. A plurality of bacteria lysis pools are arranged on the disc micro-fluidic chip. According to the invention, the bacterial lysis efficiencyand the sample treatment flux can be effectively improved; and other operation units can be integrated to realize real-time on-site detection of bacteria. The designed bacterial lysis device is portable, low in cost, easy and convenient to operate; the operation is automatic; and the device is used flexibly. The portable bacterial lysis device can meet different requirements and has the broad application prospects.
Owner:DALIAN MARITIME UNIVERSITY
A centrifugal microfluidic chip for extracting free nucleic acid and its method for extracting free nucleic acid
ActiveCN110016435BGuaranteed stabilityEfficient separation and extractionBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringBlood plasma
Owner:XI AN JIAOTONG UNIV
Air pressure supporting type siphon valve structure and centrifugal microfluidic device
The invention relates to an air pressure supporting type siphon valve structure and a centrifugal microfluidic device. The air pressure supporting type siphon valve structure comprises a pressurizing chamber and a siphon pipeline, wherein the siphon pipeline comprises a raising pipeline, a transition pipeline and a lowering pipeline which are sequentially connected; the input end of the raising pipeline communicates with a position, far away from a target rotating center, on the pressurizing chamber; the input end of the raising pipeline also communicates with a sample feeding chamber; and the output end of the lowering pipeline communicates with a collecting chamber. According to the air pressure supporting type siphon valve structure and the centrifugal microfluidic device, air pressure is creatively used for replacing capillary force to drive liquid to flow in direction opposite to the centrifugal force direction, thus high-speed centrifugal sealing effect can be achieved, and moreover, a valve is driven by air pressure to open while low-speed rotating is realized; the effect of the siphon valve is realized in centrifugal microfluidic control through the balance of the air pressure and the centrifugal force; in addition, the inner surface of the siphon pipeline is prevented from hydrophilic treatment, and hydrophilic materials are saved, so that the processing technology of a microfluidic control chip and processing quality control cost are greatly simplified.
Owner:深圳市呈晖医疗科技有限公司
Chemiluminescence immunoassay disk based on centrifugal microfluidics technology and working method thereof
PendingCN107643415ALow costHighly integratedMaterial analysisEngineeringChemiluminescence immunoassay
The invention provides a chemiluminescence immunoassay disk based on a centrifugal microfluidics technology and a working method thereof. The chemiluminescence immunoassay disk based on the centrifugal microfluidics technology comprises a sample loading port, a first reagent port, a detecting groove and a waste liquid groove, and a valve, the valve controls communication between the detecting groove and the waste liquid groove, and comprises a meandering passage formed in the disk, a relationship between a minimum rotation radius R1 of the passage and a maximum rotation radius R2 of the detecting groove is that R1-R2 is less than 0. The chemiluminescence immunoassay disk based on the centrifugal microfluidics technology has the advantages of stability, reliability, efficiency, quickness and the like.
Owner:ZHEJIANG PUSHKANG BIOTECHNOLOGY CO LTD
PCR centrifugal microfluidic device and method
PendingCN110872555AShorten the timeHigh precisionBioreactor/fermenter combinationsHeating or cooling apparatusTemperature control modeEngineering
The invention relates to a polymerase chain reaction (PCR) centrifugal microfluidic device. The device comprises a chip and thermostatic blocks; the chip is provided with at least two reaction chambers for holding reagents, the thermostatic blocks are different in temperature and arranged on the chip at intervals, and the thermostatic blocks are one-to-one corresponding to the reaction chambers and fixed relative to the reaction chambers; and the reagents can flow among different reaction chambers for periodical switching, and the different thermostatic blocks alternately heat the reagents. The manner of replacing traditional time temperature cycle with the spatial temperature cycle can reduce time required for one cycle of a PCR reaction of the reagents and improve the reaction efficiency; and at the same time, a traditional PCR reaction variable-temperature control mode is replaced with a constant-temperature control mode, so that the technical difficulty of temperature rise and fallcontrol is greatly reduced, the thermostatic blocks improve the accuracy of temperature required by the reagents in different reaction stages, and the PCR reaction effect of the reagents is ensured.
Owner:深圳市呈晖医疗科技有限公司
Acceleration-Primed Valving System for Centrifugal Microfluidics
ActiveUS20190091686A1RPM increaseEliminate needLaboratory glasswaresFluid controllersAngular velocityCapillary Tubing
A microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration-primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber.
Owner:RADISENS DIAGNOSTICS
Microfluidic temperature control system and nucleic acid analysis system
ActiveCN110804540AIncrease the heat exchange areaLow air resistanceBioreactor/fermenter combinationsBiological substance pretreatmentsTemperature controlChemical physics
The present invention relates to a microfluidic temperature control system and a nucleic acid analysis system. The nucleic acid analysis system comprises an outer shell, a cover body, a temperature zone separation frame, an inner temperature control mechanism and an outer temperature control mechanism, and an accommodating cavity is formed in the cover body; the cover body covers the outer shell;the temperature zone separation frame is located in the accommodating cavity and connected with the outer shell; the inner temperature control mechanism is located in an inner temperature area and used for heating air temperature in the inner temperature area; and the outer temperature control mechanism comprises a first heating assembly and a second heating assembly, the first heating assembly and the second heating assembly are arranged in an outer temperature area at intervals. In the nucleic acid analysis system, a hot overshoot is applied to heating control and a cold overshoot is appliedto cooling control. Therefore, complexity of the nucleic acid analysis system is ingeniously reduced by reasonably utilizing layout of the structural areas, a problem of relatively high thermal inertia of air and structural parts in a cavity of a centrifugal micro-fluidic chip is solved, and time required by PCR analysis is further shortened.
Owner:深圳市呈晖医疗科技有限公司
Centrifugal micro-fluidic device for rapidly preparing liquid drops and liquid drop preparation method
PendingCN113181982AEnable high-throughput productionFlexible size controlTransportation and packagingMixersCapillary TubingCentrifugal microfluidics
The invention discloses a centrifugal micro-fluidic device for rapidly preparing liquid drops and a liquid drop preparation method, and belongs to the technical field of biomedical materials.The centrifugal micro-fluidic device comprises an inner liquid storage device and an outer liquid storage device which are provided with hollow inner cavities, wherein inner phase liquid is injected into the inner liquid storage device, a collecting groove is formed in the bottom end of the inner cavity of the outer liquid storage device, outer phase liquid is injected into the collecting groove, and the inner liquid storage device and the center line are arranged in the inner cavity of the outer liquid storage device; a capillary tube installed on the inner liquid storage device, wherein one end of the capillary tube is communicated with the inner cavity of the inner liquid storage device, and the other end of the capillary tube is positioned above the collecting groove; and a centrifugal transmission mechanism which is connected with the inner liquid storage device and can drive the inner liquid storage device to rotate at a high speed and enable the inner phase liquid to do centrifugal motion in the inner liquid storage device, wherein centrifugal force borne by the inner phase liquid during centrifugal motion can extrude the inner phase liquid to enter the tube from one end of the capillary tube and generate liquid drops at the other end of the capillary tube. The device has the advantages that high-flux production of the liquid drops can be realized, and meanwhile, the size and the shape of the liquid drops are flexible and controllable.
Owner:NANJING DRUM TOWER HOSPITAL
Clamping mechanism for centrifugal microfluidics CD chip
ActiveCN107552119AEasy to insertGuaranteed horizontal positioningLaboratory glasswaresSupporting apparatusEngineeringMotor shaft
The invention belongs to the microfluidics field and discloses a clamping mechanism for a centrifugal microfluidics CD chip. The mechanism comprises chip support racks 1, a lever 2, a push rod 3, a positioning marble 4, a motor shaft clamping groove 5, a guide block 6 and a guide slot 7. The chip is inserted to the bottom along the guide slot 7 and can reach the accurate position by means of the horizontal positioning function of the guide block 6 and cooperation with the motor shaft clamping groove 5, and the chip is completely positioned when the positioning marble 4 in the motor shaft clamping groove 5 bounces; when the chip is required to be taken out, all that is required is to push the push rod 3 and the chip can automatically bounce under the action of the lever 2. The distance between the chip support racks 1 can be conveniently adjusted and thus the mechanism can adapt to chips with different sizes. The clamping mechanism for the centrifugal microfluidics CD chip is designed in the CD driver principle, can conveniently clamp and position the chip and has the advantages of being simple in structure, convenient to operate, reliable and high in adaptability.
Owner:NORTHWESTERN POLYTECHNICAL UNIV
Centrifugal microfluidic chip and nucleic acid analysis system
PendingCN110004023AWell mixedSimple structureBioreactor/fermenter combinationsBiological substance pretreatmentsMixing effectCentrifugal microfluidics
The invention relates to a centrifugal microfluidic chip and a nucleic acid analysis system, wherein the centrifugal microfluidic chip includes a chip substrate, a magnetic adsorption component and amagnetic component; the chip substrate is also provided with a stirring chamber and a liquid injection hole connected with the stirring chamber; the magnetic adsorption component is accommodated in the stirring chamber; the chip substrate has a rotating center, and the magnetic component is arranged outside the chip substrate and is located at a position, close to the rotating center, of the stirring chamber. On one hand, when the magnetic adsorption component moves to a position away from the magnetic component, and under the action of centrifugal force, the magnetic adsorption component moves to the position, far from the rotating center, of the stirring chamber; on the other hand, when the magnetic adsorption component moves to a position close to the magnetic component, the magnetic adsorption component moves to a position, close to the rotating center, of the stirring chamber under the action of magnetic adsorption. An ideal mixing effect can be achieved, and a certain cracking effect is achieved and is stable and effective on the premise of simplifying the structure and needing no complicated instruments and equipment.
Owner:深圳市呈晖医疗科技有限公司
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