56 results about "Centrifugal microfluidics" patented technology

Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal microfluidic device includes: a rotatable platform; a sample chamber which is disposed in the rotatable platform and houses a fluid sample; a distribution channel connected to an outlet of the sample chamber; a valve which is disposed in the outlet of the sample chamber; a plurality of non-vented reaction chambers which are disposed in the rotatable platform outside of the distribution channel in the radial direction; and a plurality of inlet channels connecting the distribution channel with the reaction chambers.

A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.

The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the movement of the blood sample; and a waste sample chamber in which the blood sample is accommodated after passing through the microchannels. According to the present invention, multiple drug tests can be performed on a single blood sample at one time in multiple channels such that multiple tests is possible with respect to complex platelet functions, and thus testing time is reduced and testing costs can be saved.

The invention provides a centrifuging micro-fluidic control chip for free nucleic acid extraction and a method for extracting free nucleic acid, and belongs to the technical field of free nucleic acidseparating and extracting devices. The centrifuging micro-fluidic control chip comprises a disc, plasma separating chambers, nucleic acid extraction sample cavities, immiscible phase cavities and eluting cavities, wherein the plasma separating chambers, the nucleic acid extraction sample cavities, the immiscible phase cavities and the eluting cavities are in rotary symmetric distribution; each plasma separating chamber communicates with the corresponding nucleic acid extraction sample cavity through a corresponding passive siphon; and each nucleic acid extraction sample cavity communicates with the corresponding immiscible phase cavity and the corresponding eluting cavity through arch capillary microchannels. According to the centrifuging micro-fluidic control chip disclosed by the invention, a dynamic centrifuging micro-fluidic control method and a static immiscible phase micro-fluidic control method are combined for the first time, and the designed immiscible phase nucleic acid extracting and purifying structure realizes uniform mixing under the premise that the interface stability is not influenced; the plasma separating structure is integrated on the centrifuging micro-fluidiccontrol chip, so that the purpose of extracting and purifying free nucleic acid from 4mL whole blood fully-automatically within 15 minutes can be realized, the centrifuging micro-fluidic control chipis the fastest device for extracting and purifying the free nucleic acid from the whole blood at present, and the centrifuging micro-fluidic control chip is hopefully applied to liquid biopsy of thefree nucleic acid.