Application of zidovudine used for preparation of medicine for treating autoimmune neuritis

An autoimmune, zidovudine technology, applied in the field of medicine, can solve problems such as the limited scope of use of zidovudine

Inactive Publication Date: 2017-01-18
丁静
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide the application of zidovudine for the preparation of autoimmune neuritis treatment drugs aiming

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  • Application of zidovudine used for preparation of medicine for treating autoimmune neuritis
  • Application of zidovudine used for preparation of medicine for treating autoimmune neuritis
  • Application of zidovudine used for preparation of medicine for treating autoimmune neuritis

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Embodiment Construction

[0020] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0021] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

According to the invention, experimental autoimmune neuritis is used as an experimental environment to research intervention effect of zidovudine on the immune system. It is found through experiments that zidovudine can increase expression quantity of nuclear transcription factor 2 and heme oxygenase 1 so as to induce differentiation of M1-type macrophage to M2-type macrophage and furthermore promote neighboring cell proliferation and tissue repairing by the utilization of cytokines released by the M2-type macrophage. In addition, it is found that oral administration of zidovudine can down-regulate messenger RNA level of pro-inflammatory cytokines gamma-interferon, tumor necrosis factor alpha, interleukin 6 and interleukin 17 and up-regulate messenger RNA level of anti-inflammatory cytokines interleukin 4 and 10 so as to improve inflammatory injury in an EAN model. Based on the above positive discovery, the new application of zidovudine for preparation of a medicine for treating autoimmune neuritis is determined. The invention is of positive clinical significance.

Description

technical field [0001] The invention relates to the technical field of medicine, and further relates to the new medical application of the substance, in particular to the application of zidovudine for preparing the medicine for autoimmune neuritis. Background technique [0002] Zidovudine is an antiviral drug for the treatment of AIDS or AIDS-related syndrome patients and immunodeficiency virus (HIV) infection. On March 19, 1987, the US Food and Drug Administration approved the drug for marketing. Zidovudine is the world's first anti-AIDS drug approved by the US FDA. Because of its definite curative effect, it has become the most basic component of the "cocktail" therapy. This product is an antiviral drug with high activity against retroviruses including human immunodeficiency virus (HIV) in vitro. In virus-infected cells, it is phosphorylated by cellular thymidine kinase to zidovudine triphosphate, which selectively inhibits HIV reverse enzyme, leading to the termination ...

Claims

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Application Information

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IPC IPC(8): A61K31/7072A61P25/00A61P37/02A61P29/00
CPCA61K31/7072
Inventor 丁静李银柱
Owner 丁静
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