Unlock instant, AI-driven research and patent intelligence for your innovation.

Improved mouthwash formulations

A technology of mouthwash and total volume, applied in the direction of medical preparations containing active ingredients, oral care, local antibacterial agents, etc., can solve problems such as reducing patient compliance

Active Publication Date: 2021-08-17
CURASEPT ADS SRL
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chlorhexidine has the major disadvantage of causing brown staining on tooth surfaces as well as on restorations and tongue, which can significantly reduce patient compliance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Improved mouthwash formulations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] According to the above description, the following mouthwash formulations may be:

[0062] components quantity water Top up to 100% sugar 6-10％ humectant 0.1-0.2％ Surfactant 1.0-3％ ascorbic acid 0.1-1.5% (w / v) Chlorhexidine digluconate 0.05-0.3% (w / w) PVP-VA copolymer 0.05-0.3％ Sodium hyaluronate 0.05-1.2％ Spice (arome) 0.05-0.15％ Sodium metabisulfite 0.1-0.5% (w / v) Sodium citrate 1.0-1.5％ citric acid 0.01-0.015 Colorant 0.0005-0.0009％

Embodiment 2

[0064] The purpose of the clinical trial was to evaluate the effectiveness of anti-staining by combining 0.2% chlorhexidine, PVP-VA, hyaluronic acid and (anti-tarnish system) dental mouthwash with only 0.2% chlorhexidine and systemic mouthwash.

[0065] Materials and methods

[0066] Seventeen volunteers have been recruited in the study, selected at the Clinica Universitaria of the IRCCS Istituto Ortopedico Galeazzi (Milan).

[0067] Patients must meet the following requirements:

[0068] 1. The patient is in good health and has no systemic disease;

[0069] 2. Agree to participate through informed consent;

[0070] 3. Over 18 years old;

[0071] 4. Non-smokers or light smokers (less than 5 cigarettes per day);

[0072] 5. Good oral hygiene with a low level of plaque index (FMPS and FMBS ≤ 25%).

[0073] Prior to the study, patients had undergone a professional oral hygiene session to remove possible plaque and stain already present on the tooth surface. There are pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to anti-staining systems for chlorhexidine-based mouthwashes and their use in the field of therapy and / or prophylaxis.

Description

Background technique [0001] Chlorhexidine (chlorhexidine) has been known since more than two decades as the gold standard for antiplaque and antimicrobial activity. [0002] Due to its mechanism of competition with calcium ions, chlorhexidine is in fact able to inhibit the formation of new plaque (plaque) and to break down the layer already deposited on the tooth surface acting on its matrix. [0003] Chlorhexidine-based mouthwashes are very useful in the treatment of periodontal lesions and for enhancing the postoperative healing process. [0004] The antiseptic effect of chlorhexidine is due to its ability to establish chemical bonds with anionic groups (phosphate, sulfate, carboxyl groups) present at the level of the bacterial cell wall and induce a significant increase in cell permeability and alter the osmotic balance. However, chlorhexidine has the major disadvantage of causing brown staining of tooth surfaces as well as restorations and tongues, which can significantly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/73A61K8/23A61K8/365A61K8/43A61K8/67A61Q11/00A61P1/02A61P31/02
CPCA61K8/23A61K8/365A61K8/43A61K8/676A61K8/735A61K8/8182A61Q11/00A61K31/155A61K9/006A61P1/02A61P31/02A61K8/19A61K8/34A61K8/466A61K8/69
Inventor 洛伦佐·博约基
Owner CURASEPT ADS SRL