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Light and temperature dual responsive copolymer, its synthesis method and hydrogel system

A dual-response, synthetic method technology, applied in prosthetics, medical science, etc., can solve the problems of limited application research in the biomedical field, and achieve good biocompatibility and biodegradability

Inactive Publication Date: 2018-02-23
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the research is on non-biodegradable polymer materials that respond to a single light or thermal stimulus. There are few reports on the application of light and thermal stimulus to biodegradable polymer hydrogels, and in the field of biomedicine. Applied research in

Method used

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  • Light and temperature dual responsive copolymer, its synthesis method and hydrogel system
  • Light and temperature dual responsive copolymer, its synthesis method and hydrogel system
  • Light and temperature dual responsive copolymer, its synthesis method and hydrogel system

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 0.9.

[0036] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.

[0037] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:

[0038] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator

[0039] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...

Embodiment 2

[0051] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 0.8.

[0052] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.

[0053] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:

[0054] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator

[0055] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...

Embodiment 3

[0067] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 1.0.

[0068] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.

[0069] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:

[0070] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator

[0071] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...

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Abstract

The invention discloses a light- and temperature-responsive copolymer, a synthesis method thereof and a hydrogel system. Lactone-polyethylene glycol-polycaprolactone triblock copolymer, wherein the polycaprolactone / polyethylene glycol segment length ratio is 0.8-1.0. The synthesis method uses bis-o-nitrobenzyl polyethylene glycol with photosensitive groups at both ends as a macromolecular initiator to initiate ring-opening polymerization of caprolactone monomers to obtain polycaprolactone-polyethylene glycol- Polycaprolactone triblock copolymer. The hydrogel in the invention has good light and temperature response characteristics, and also has good biocompatibility and biodegradability, and is an implant material that can be used in vivo.

Description

technical field [0001] The invention belongs to the technical field of stimuli-responsive materials, and in particular relates to a light- and temperature-responsive copolymer, a synthesis method thereof, and a hydrogel system. Background technique [0002] Responsive polymers are important smart materials whose structures and properties can be mutated by a variety of internal or external stimuli such as changes in enzymes, sugars, pH, redox, ultrasound, temperature, and light. Among these stimuli, light is a clean and efficient stimulus that enables the modulation of the structure and properties of materials from outside the system. The photoswitch can control the start and stop of the photoreaction without any additional reagents. During the reaction, the selectivity and rate of the reaction and the properties of the polymer can be controlled by adjusting the wavelength and intensity of the light. Many polymer application systems are related to photoresponse, including p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/664A61L27/18A61L27/58
CPCA61L27/18A61L27/58C08L67/04
Inventor 郝建原周思瑶刘钰叶友全
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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