Light and temperature dual responsive copolymer, its synthesis method and hydrogel system
A dual-response, synthetic method technology, applied in prosthetics, medical science, etc., can solve the problems of limited application research in the biomedical field, and achieve good biocompatibility and biodegradability
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Embodiment 1
[0035] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 0.9.
[0036] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.
[0037] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:
[0038] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator
[0039] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...
Embodiment 2
[0051] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 0.8.
[0052] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.
[0053] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:
[0054] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator
[0055] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...
Embodiment 3
[0067] A light- and temperature-responsive copolymer, which is a polyethylene glycol (PEG) composed of a photosensitive o-nitrobenzyl group (ONB) connected to a hydrophobic segment polycaprolactone (PCL) and a hydrophilic segment polyethylene glycol (PEG). Lactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-ONB-PEG-ONB-PCL), wherein the number-average molecular weight ratio of the PCL / PEG segment in the copolymer is 1.0.
[0068] The number average molecular weight of the hydrophilic segment PEG in the copolymer of this embodiment is 1000.
[0069] In this embodiment, the specific synthesis steps of PCL-ONB-PEG-ONB-PCL triblock copolymer are as follows:
[0070] S1: Preparation of di-o-nitrobenzyl polyethylene glycol macroinitiator
[0071] S11: Weigh the following materials: 5-hydroxy-2-nitrobenzyl alcohol, sodium hydride, anhydrous tetrahydrofuran, tosylated polyethylene glycol, the 5-hydroxy-2-nitrobenzyl alcohol and sodium hydride The molar ratio of 5-hy...
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