Thermosensitive poly(proline-sarcosine) material and preparation method thereof

A technology of proline and sarcosine, which is applied in the field of temperature-sensitive poly(proline-sarcosine) materials and their preparation, can solve the problem of not having biocompatibility, biodegradability and temperature-sensitive properties at the same time , single and other problems, to achieve the effect of excellent temperature response characteristics, excellent biocompatibility and biodegradability
CN106432713BInactive Publication Date: 2018-12-25HEBEI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEBEI UNIVERSITY
Publication Date
2018-12-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a thermo-sensitive poly(proline-creatine) material, belongs to the field of thermo-sensitive polymers in smart materials and relates to a polymer material with the advantages of high biocompatibility, biodegradability and thermo-sensitivity. The thermo-sensitive poly(proline-creatine) material is composed of constitutional units shown in a formula (I), is a random copolymer and has a molecular weight of (0.8-1.6)*10<4>, wherein the structural formula is as shown in the specification, and a ratio of n to m is equal to 1:(0.09-0.76). The invention also discloses a method for preparing the thermo-sensitive poly(proline-creatine) material. The polymer material prepared by the invention has the thermo-sensitivity and excellent biocompatibility and biodegradability.
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Description

technical field

[0001] The invention belongs to the field of temperature-sensitive polymers in intelligent materials, and relates to a molecular design and preparation method of a polymer material with good biocompatibility, biodegradability and temperature-sensitive properties, in particular to a temperature-sensitive polymer material. Poly(proline-sarcosine) material and preparation method thereof, the polymer material itself is a single polymer, rather than a mixture, graft, or blend of two or more polymers in the modification method thing. Background technique

[0002] Temperature-sensitive polymer materials are a class of intelligent materials that have reversible corresponding behaviors to external temperature changes. One of the most important physical parameters is the lowest critical solution temperature (LCST) or the highest critical solution temperature (UCST), that is, the polymer The temperature at which a significant phase change reversibly occurs in an aqueou...

Claims

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