39 results about "Protuberic acid" patented technology

The invention relates to a method for preparing soematoglutide. A solid-liquid phase-binding fragment condensation scheme is adopted and includes conducting solid phase synthesis to obtain side chainprotecting peptide, conducting liquid phase fragment condensation to obtain fully protected semaglutide, then conducting cleavage to obtain crude semaglutide and conducting purification salt exchangeto obtain the semaglutide. A pseudoproline strategy is adopted to reduce by-products caused by racemization. Acccording to the method, impurities are reduced, the yield is improved, the synthesis timeis reduced, the waste liquid discharge is reduced, the synthesis cost is greatly reduced, and the method is very beneficial to industrial production.

The invention discloses polypeptide, a preparation method and an application thereof. An amino acid sequence of the polypeptide is shown as SEQID NO:1. The polypeptide provided by the invention is a bioactive polypeptide extracted from skins of northern leopard frogs, is leucine-valine-arginine-glycine-cysteine-tryptophan-threonine-lysine-serine-tyrosine-proline-proline-lysine-proline-cysteine-phenylalanine-valine-arginine polypeptide, can penetrate in unilamellar lipid vesicles with negative charges, inhibit formation of eosinophilic granulocyte and granulocyte-macrophage colonies and reduce activity of eosinophilic granulocyte for forming precursor cells and mast cells, and achieves the object of treating allergic rhinitis and asthma syndrome by combining active centers of tryptase to inhibit the activity of protease.

The invention discloses a method for preparing 2,3-butanedione from paraformaldehyde. The method comprises the following steps of: preparing methyl vinyl ketone in one step from paraformaldehyde and acetone which serve as raw materials and L-proline serving as a catalyst through a condensation reaction of aldehydes and ketone and a dehydration reaction; and preparing 1,2-epoxy butanone from the methyl vinyl ketone serving as a raw material, hydrogen peroxide serving as an oxidant and a titanium and silicon molecular sieve serving as a catalyst by a catalytic oxidation method, and adding sodium hydrogensulfite for heating, and performing pinacol rearrangement to prepare 2,3-butanedione. Compared with the conventional method for preparing the 2,3-butanedione, the method has the characteristics of low cost, environmental-friendliness, high conversion rate of the paraformaldehyde and selectivity of the 2,3-butanedione and the like, and provides an environmental-friendly synthetic method for the industrial production of the 2,3-butanedione.

The invention relates to a method for preparing an N-substituted pyrrole derivative. The method comprises the step of carrying out a reaction on aromatic aldehyde and 4-hydroxy-L-proline in a reaction medium at the temperature of 80 DEG C-200 DEG C in the presence of an acidic catalyst so as to prepare a target product. The method for preparing the N-substituted pyrrole derivative has the advantages that a raw material is cheap and available, operation is simple and practicable, inert gas dose not need to be used for protection in the whole preparation process, yield is high, and the like.

Novel solution complexes of zoledronic acid are described which give rise to improved properties of zoledronic acid. The invention includes aqueous solution and molecular complexes of zoledronic acid with and optical isomers of asparagine, histidine, arginine and proline as well as pharmaceutical complexes containing them and methods of treatment using them.

The invention discloses a tetrahydroindole compound, and a preparation method and an application thereof, and belongs to the technical field of the chemical synthesis. Raw materials comprising a 1,3-cyclohexanedione compound, nitroalkene and amine undergo a one-pot process under microwave radiation in water as a solvent under the action of L-proline as a catalyst to prepare the tetrahydroindole compound in high yield. The catalyst used in the invention is a non-transition metal catalyst having a low price, so the synthesis cost is substantially reduced; the reaction condition in a catalysis system is mild and can be easily controlled, and the product can be obtained through a domino cyclized multi-component one-step reaction; and the method has the advantages of green and pollution-free experiment program, simple and effective experiment operation, and diversified product structure. The method which uses water as a solvent has the characteristics of simple post-treatment, small pollution to the environment, no damages to the health of the body of an operation worker, and easy realization of the industrialized production.

The invention discloses a vegetarian chicken-flavor seasoning powder which is prepared by the following steps: uniformly mixing corn-protein-derived acid-hydrolyzed vegetable protein solution, glucose, thiamine hydrochloride, L-glutamic acid, L-proline, glycine powder, L-cysteine hydrochloride, white granulated sugar, soft water and hydrogenated soybean oil to obtain a raw material solution, regulating the pH value of the raw material solution to 7.0-7.5, heating to 98-101 DEG C, and keeping the temperature to perform Maillard reaction for 0.5-2 hours to obtain a paste; and finally, carrying out vacuum drying on the paste and pulverizing into powder, or carrying out spray drying to obtain the powder. The seasoning powder has strong aroma, and can achieve the goal of effective seasoning without additionally adding essence.

The invention relates to compounds of general formula (I), which can be used particularly as structural mimetics of proline-rich peptides and are therefore capable of binding PRM binding domains (proline-rich motif binding domains) of proteins. The invention also relates to the use of said compounds as pharmaceutical active agents and the use of these pharmaceutical active agents for treating bacterial diseases, neurodegenerative diseases and tumors.

The invention provides a method for preparing zofenopril calcium. N-acetyl-L-oxyproline is adopted as a raw material. The method includes: a step of subjecting the N-acetyl-L-oxyproline and methanol to esterification, subjecting the obtained product and paratoluensulfonyl chloride to sulfonation, and subjecting the obtained product and thiophenol prepared from a sodium thiophenolate solution to thiophenyl substitution; a step of hydrolyzing the obtained product into an free acid by utilization of an alkali, performing recrystallization for purification, and performing deacetylation with hydrochloric acid to obtain (cis)-4-thiophenyl-L-proline hydrochloride; a step of reacting (S)-3-(benzoyl sulfhydryl)-2-methylpropanoic acid with thionyl chloride to obtain (S)-3-(benzoyl sulfhydryl)-2-methyl propionylchloride; a step of reacting the (S)-3-(benzoyl sulfhydryl)-2-methyl propionylchloride with the (cis)-4-thiophenyl-L-proline hydrochloride to obtain the free acid zofenopril; and a step of forming a potassium salt, purifying and reacting with a calcium chloride to obtain a calcium salt, thus obtaining a final product zofenopril calcium. The method has characteristics of easily available raw materials, simple preparation method, mild conditions, easy control, reasonable monitoring points in the preparation process, effective removal and control of impurities, capability of producing the final product with the needed crystal form preferentially in a high ratio, suitability for industrial production and large application value.

The invention discloses a method for preparing a recyclable chiral catalyst and application thereof. The method comprises the following steps of: stirring acetic acid solution of polyvinyl alcohol or dimethyl formamide solution of polyacrylonitrile and a certain amount of proline or proline derivative uniformly, then putting the mixture into an injector, and performing electrostatic spinning to prepare a fiber membrane of a nano structure, wherein the spinning voltage is 10kV and the receiving distance is 15 centimeters; performing vacuum drying on the membrane at the temperature of between 60 and 100 DEG C to obtain a proline carried nano fiber membrane, then stirring the obtained membrane in dichloromethane solution of triethylamine for half an hour, and performing vacuum drying to obtain the catalyst; and sealing and storing the catalyst for later use.

The invention discloses a synthetic method of an oxidation indoles compound. The synthetic method comprises the following steps of: taking an anilines compound as a raw material to generate an adjacent bromaniline compound; getting cuprous iodide as a catalyst and getting L-proline and inorganic salt cesium carbonate as additives to conveniently achieve an arylation coupling reaction between molecules of a bromoaniline compound and a beta-dicarbonyl compound; and finally carrying out intramolecular cyclization so as to further synthesize the oxoindole compound. According to the synthetic method disclosed by the invention, selected raw materials are easy to obtain; the catalyst and ligands are cheap; a reaction condition is mild; and the most important is that a simple recrystallizing method is adopted during post-purifying processing of a product; the synthetic method has the advantages of being simple and convenient to operate, and high in chemical yield and the like, and is more suitable for industrial production, and has a good application prospect; and another new way and method are provided for synthesizing and purifying the oxoindole compound.

The invention discloses a plant origin amino acid cleansing mousse composition and a preparation method thereof.A formula comprisessodium cocoyl apple amino acids, sodium lauroyl oat amino acids, water, preservative, butanediol, lysine, tyrosine, and phenylalanine; each component comprises in percentage by mass: 1%to 30% of sodium cocoyl apple amino acids, 1%to 20% of sodium lauroyl oat amino acids, 1%to 50% of water, 0.1%to 0.5% of preservative, 0.01%to 5% of butanediol, 0.01%to 5% of lysine, 0.01%to 5% of histidine, 0.01%to 5% ofarginine, 0.01%to 5% of aspartic acid, 0.01%to 5% of threonine,0.01%to 5% of serine, 0.01%to 5% of glutamic acid, 0.01%to 5% of proline, 0.01%to 5% of glycine, 0.01%to 5% of alanine, 0.01%to 5% of valine, 0.01%to 5% of isoleucine, 0.01%to 5% of leucine, 0.01%to5% of tyrosine, and 0.01%to 5% ofphenylalanine.According to the plant origin amino acid cleansing mousse composition and the preparation method thereof, safety and reliability are realized, strongly alkaline ingredients such as surfactants, foaming agents, and soap base are not added, amino acids, faintly acidamino acidsurfactant isused, and the PH value is close to human skin.

The invention discloses a preparation method for a crude proline product, and belongs to the technical field of separation and extraction. The method comprises the following steps that proline fermentation liquor is firstly adsorbed by strong acid cation resin and then is sequentially filtered through weak alkaline anion resin and weak acid cation resin so as to obtain the proline crude product. The crude proline product prepared by using the method is proline monohydrate and has the advantages of being good in crystal form, high in purity (the purity is greater than 99%, and the light transmittance is greater than 99%) and capable of controlling the specific rotation to be within -84.5 degrees to -86 degrees.

Method of producing C8-C15 hydrocarbons comprising providing a ketone starting material; providing an aldol starting material comprising hydroxymethylfurfural; mixing the ketone starting material and the aldol starting material in a reaction in the presence of a proline-containing catalyst selected from the group consisting of Zn(Pro)2, Yb(Pro)2, and combinations thereof, or a catalyst having one of the structures (I), (H) or (III), and in the presence of a solvent, wherein the solvent comprises water and is substantially free of organic solvents, where (I), (II) and (III) respectively are:where R1 is a C1-C6 alkyl moiety, X═(OH) and n=2.In (III), X may be CH2, sulfur or selenium, M may be Zn, Mg, or a lanthanide, and R1 and R2 each independently may be a methyl, ethyl, phenyl moiety.

The present invention provides a method for improving salt tolerance of a plant so as to enable the plant to be cultivated under a high salt concentration condition. The present invention discloses a method for improving salt tolerance of a plant, including suppressing or inhibiting a function of PERK13 (Proline-rich extensin-like receptor kinase 13) in a plant; the method for improving salt tolerance of a plant, wherein an antagonist of PERK13 is brought into contact with a root of the plant; the method for improving salt tolerance of a plant, wherein the antagonist is one or more species of microorganisms or a secretion therefrom; and the method for improving salt tolerance of a plant, wherein the suppression of the function of the PERK13 is carried out by suppressing expression of PERK13 gene, or the inhibition of the function of the PERK13 is carried out by inhibiting expression of PERK13 gene.

The invention discloses a preparation method of D-threonine and belongs to the technical field of amino acid synthesis. The preparation method of the D-threonine specifically comprises the following steps: S1, synthesizing, namely dissolving copper glycine in water, adding D-proline derivatives, cooling to 5-10 DEG C, dropwise adding acetaldehyde, reacting for 20-28 hours, separating out the D-threonine copper salt out, separating a solid substance, washing the solid substance with 70-80% ethyl alcohol, and removing a washing liquor to obtain the D-threonine copper salt; S2, desalting, namely dissolving the D-threonine copper salt obtained in the step S1 in 8-12% ammonia water, removing copper and concentrating to obtain a D-threonine concentrated solution; S3, refining, namely decolorizing and crystallizing the D-threonine concentrated solution to prepare the D-threonine. By adopting the preparation method of D-threonine, a novel method for synthesis of the D-threonine is provided. The preparation method of D-threonine is simple in synthetic route, low in production cost, convenient to operate and high in yield. The prepared D-threonine is high in content of chirality and applicable to large-scale production in factories.

The present invention refers to new purified compositions of long chain polyunsaturated fatty acids, or their salts or esters, characterized by being essentially free from other usually present—but structurally different—components, such as furan fatty acids, phytanic and pristanic acids, squalene, and some oligomers, as well as several “persistent” environmental pollutants, such as polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans, polychlorinated biphenyls, polybrominated diphenyl-ethers, polycyclic aromatic hydrocarbons, and others, which are also usually present and extremely toxic. The invention also refers to the purification method to obtain said compositions and the use thereof as food, food for special medical use, food and diet supplement, and drug.

Method of producing C8-C15 hydrocarbons. comprising providing a ketone starting material; providing an aldol starting material comprising chloromethylfurfural; mixing the ketone starting material and the aldol starting material in a reaction in the presence of a proline-containing catalyst selected from the group consisting of Zn(Pro)2, Yb(Pro)3, and combinations thereof, or a catalyst having one of the structures (I), (II) or (III), and in the presence of a solvent, wherein the solvent comprises water and is substantially free of organic solvents, where (I), (II) and (III) respectively are:where R1 is a C1-C6 alkyl moiety, X═(OH) and n=2.In (III), X may be CH2, sulfur or selenium, M may be Zn, Mg, or a lanthanide, and R1 and R2 each independently may be a methyl, ethyl, phenyl moiety.

A sulfuric acid decolorant comprises 50-60wt% of anhydrous ethanol, 15-25wt% of diatomite, 15-25wt% of active carbon, and 1-5wt% of free acid 3-acetylmercapto-2-methylpropiono-L-proline. The sulfuric acid decolorant which utilizes diatomite and active carbon to realize a dual adsorption function adsorbs pigments free in sulfuric acid, allows contained pigments to disappear, and can acidify diatomite and reduce the side reactions of dilute sulfuric acid through the addition of free acid 3-acetylmercapto-2-methylpropiono-L-proline, The sulfuric acid decolorant can rapidly and effectively remove the color of sulfuric acid and has a low cost.

The invention relates to a methylbenzene recycling method applied to a sulfosalicylic acid method for determination of proline contents inside plants. The purpose of the invention is to solve the technical problems that a large amount of methylbenzene waste liquor is produced in the sulfosalicylic acid method for determination of proline contents inside plants, the direct pouring of the waste liquor results in serious pollution to the environment and the testing cost is high. The recycling method comprises a decoloring step and a filtering step. The recycling method has the advantages of reducing the pollution of the methylbenzene waste liquor in the sulfosalicylic acid method for determination of proline contents inside plants to the environment, improving the utilization rate of organic solvent and reducing the testing cost, and has the characteristics of being simple in operation, high in processing capacity and easy in manual control and the like; the recycling method has certain application value to the physiological characteristics of plants; the methylbenzene recovery rate is 85%; the recycling times of active carbon is eight; and the recycling method is applicable to treatment of a large amount of samples.

The invention discloses a thermo-sensitive poly(proline-creatine) material, belongs to the field of thermo-sensitive polymers in smart materials and relates to a polymer material with the advantages of high biocompatibility, biodegradability and thermo-sensitivity. The thermo-sensitive poly(proline-creatine) material is composed of constitutional units shown in a formula (I), is a random copolymer and has a molecular weight of (0.8-1.6)*10<4>, wherein the structural formula is as shown in the specification, and a ratio of n to m is equal to 1:(0.09-0.76). The invention also discloses a method for preparing the thermo-sensitive poly(proline-creatine) material. The polymer material prepared by the invention has the thermo-sensitivity and excellent biocompatibility and biodegradability.

The invention discloses a type of pyrrolidine derivative with novel structure, a synthesis method and purposes thereof. The structural formula of the pyrrolidine derivative is as follows: the pyrrolidine derivative can be conveniently prepared with the natural or unnatural proline derivative as the raw material, and a preparation route has higher yield and three-dimensional selectivity. This typeof derivative can be used for synchronizing 2,2'- pyrrolidine.

The invention discloses a chiral 3-(2-nitro ethyl) tetrahydrofuran compound and a preparation method thereof. The preparation method specifically comprises the following steps: performing Michael addition reaction on 2-hydroxytetrahydrofuran and nitroalkene by using proline-derived chiral pyrrolidine serving as a catalyst, and performing Et3SiH / BF3.Et2O reduction to remove 2-hydroxyl to obtain the product. According to the chiral 3-(2-nitro ethyl) tetrahydrofuran compound and the preparation method for the same, the compound is novel in structure and high in enantiomeric purity; a plurality of active natural products and medicaments contain tetrahydrofuran structures, so that the compound has high application value in the total synthesis of the natural products and the discovery of new medicaments, and has good application prospect.

The invention discloses a preparation method of chiral Beta-indolyl-Gamma-aldehyde group nitro alkanes. According to the method, (S)-diphenyl prolinol trimethylsilyl ether is used as a catalyst, methylene chloride is used as a solvent, and indol 3-position derived nitroolefin and aliphatic aldehyde are used as reactants to react under -30 DEG C to room temperature for 0.5 to 72 hours to obtain the chiral Beta-indolyl-Gamma-aldehyde group nitro alkanes. The invention achieves the synthesis method of synthetizing chiral Beta-indolyl-Gamma- aldehyde group nitro alkanes from indol 3-position derived nitroolefin and aliphatic aldehyde with L-proline derivative chiral secondary amine as a catalyst for the first time, which has higher yield and stereoselectivity.

The invention provides a hydrate inhibitor and application thereof. The hydrate inhibitor provided by the invention is prepared from proline; a hydrate inhibiting method comprises the step of adoptingthe hydrate inhibitor for inhibiting the generation of a hydrate in an inhibition system, wherein the system is an oil-water system, a gas-water system or an oil-water-gas system. The hydrate inhibitor provided by the invention is low in toxicity, non-volatile, easy to degrade, environmentally-friendly and the like; in addition, a balance condition of hydrate generation can be greatly improved, and the hydrate inhibitor has favorable a thermodynamics inhibiting effect.